Plant Cell Journal of Pharmacology and Experimental Therapeutics
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Plant Cell, Vol. 10, 135-154, Copyright © 1998, American Society of Plant Physiologists

The AmMYB308 and AmMYB330 Transcription Factors from Antirrhinum Regulate Phenylpropanoid and Lignin Biosynthesis in Transgenic Tobacco

Lodovico Tamagnonea, Angel Meridaa, Adrian Parrb, Steve Mackaya, Francisco A. Culianez-Maciaa, Keith Robertsa, and Cathie Martina
a John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom
b Institute of Food Research, Colney, Norwich NR4 7UA, United Kingdom

Correspondence to: Cathie Martin, martin{at}bbsrc.ac.uk (E-mail), 44-1603-456844 (fax).

MYB-related transcription factors are known to regulate different branches of flavonoid metabolism in plants and are believed to play wider roles in the regulation of phenylpropanoid metabolism in general. Here, we demonstrate that overexpression of two MYB genes from Antirrhinum represses phenolic acid metabolism and lignin biosynthesis in transgenic tobacco plants. The inhibition of this branch of phenylpropanoid metabolism appears to be specific to AmMYB308 and AmMYB330, suggesting that they recognize their normal target genes in these transgenic plants. Experiments with yeast indicate that AmMYB308 can act as a very weak transcriptional activator so that overexpression may competitively inhibit the activity of stronger activators recognizing the same target motifs. The effects of the transcription factors on inhibition of phenolic acid metabolism resulted in complex modifications of the growth and development of the transgenic plants. The inhibition of monolignol production resulted in plants with at least 17% less lignin in their vascular tissue. This reduction is of importance when designing strategies for the genetic modification of woody crops.




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