Plant Cell Journal of Pharmacology and Experimental Therapeutics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (125)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhou, N.
Right arrow Articles by Glazebrook, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, N.
Right arrow Articles by Glazebrook, J.
Agricola
Right arrow Articles by Zhou, N.
Right arrow Articles by Glazebrook, J.
Plant Cell, Vol. 10, 1021-1030, June 1998, Copyright © 1998, American Society of Plant Physiologists

PAD4 Functions Upstream from Salicylic Acid to Control Defense Responses in Arabidopsis

Nan Zhoua,b, Tina L. Tootlea, Frank Tsuic, Daniel F. Klessigc, and Jane Glazebrooka
a Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742
b Department of Plant Biology, University of Maryland, College Park, Maryland 20742
c Waksman Institute, Rutgers The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, New Jersey 08854-8020

Correspondence to: Jane Glazebrook, glazebro{at}umbi.umd.edu (E-mail), 301-314-9075 (fax).

The Arabidopsis PAD4 gene was previously shown to be required for synthesis of camalexin in response to infection by the virulent bacterial pathogen Pseudomonas syringae pv maculicola ES4326 but not in response to challenge by the non-host fungal pathogen Cochliobolus carbonum. In this study, we show that pad4 mutants exhibit defects in defense responses, including camalexin synthesis and pathogenesis-related PR-1 gene expression, when infected by P. s. maculicola ES4 326. No such defects were observed in response to infection by an isogenic avirulent strain carrying the avirulence gene avrRpt2. In P. s. maculicola ES4 326–infected pad4 plants, synthesis of salicylic acid (SA) was found to be reduced and delayed when compared with SA synthesis in wild-type plants. Moreover, treatment of pad4 plants with SA partially reversed the camalexin deficiency and PR-1 gene expression phenotypes of P. s. maculicola ES4 326–infected pad4 plants. These findings support the hypothesis that PAD4 acts upstream from SA accumulation in regulating defense response expression in plants infected with P. s. maculicola ES4 326. A working model of the role of PAD4 in governing expression of defense responses is presented.




This article has been cited by other articles:


Home page
 Plant Physiol.Home page
B. Chanda, S. C. Venugopal, S. Kulshrestha, D. A. Navarre, B. Downie, L. Vaillancourt, A. Kachroo, and P. Kachroo
Glycerol-3-Phosphate Levels Are Associated with Basal Resistance to the Hemibiotrophic Fungus Colletotrichum higginsianum in Arabidopsis
Plant Physiology, August 1, 2008; 147(4): 2017 - 2029.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. Yasuda, A. Ishikawa, Y. Jikumaru, M. Seki, T. Umezawa, T. Asami, A. Maruyama-Nakashita, T. Kudo, K. Shinozaki, S. Yoshida, et al.
Antagonistic Interaction between Systemic Acquired Resistance and the Abscisic Acid-Mediated Abiotic Stress Response in Arabidopsis
PLANT CELL, June 1, 2008; 20(6): 1678 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 Mol PlantHome page
C. Denoux, R. Galletti, N. Mammarella, S. Gopalan, D. Werck, G. De Lorenzo, S. Ferrari, F. M. Ausubel, and J. Dewdney
Activation of Defense Response Pathways by OGs and Flg22 Elicitors in Arabidopsis Seedlings
Mol Plant, May 22, 2008; (2008) ssn019v1.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
S. Yan, H. Liu, T. J. Mohr, J. Jenrette, R. Chiodini, M. Zaccardelli, J. C. Setubal, and B. A. Vinatzer
Role of Recombination in the Evolution of the Model Plant Pathogen Pseudomonas syringae pv. tomato DC3000, a Very Atypical Tomato Strain
Appl. Envir. Microbiol., May 15, 2008; 74(10): 3171 - 3181.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. G. Bakker, M. B. Traw, C. Toomajian, M. Kreitman, and J. Bergelson
Low Levels of Polymorphism in Genes That Control the Activation of Defense Response in Arabidopsis thaliana
Genetics, April 1, 2008; 178(4): 2031 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. Nafisi, S. Goregaoker, C. J. Botanga, E. Glawischnig, C. E. Olsen, B. A. Halkier, and J. Glazebrook
Arabidopsis Cytochrome P450 Monooxygenase 71A13 Catalyzes the Conversion of Indole-3-Acetaldoxime in Camalexin Synthesis
PLANT CELL, June 1, 2007; 19(6): 2039 - 2052.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
K. Nobuta, R.A. Okrent, M. Stoutemyer, N. Rodibaugh, L. Kempema, M.C. Wildermuth, and R.W. Innes
The GH3 Acyl Adenylase Family Member PBS3 Regulates Salicylic Acid-Dependent Defense Responses in Arabidopsis
Plant Physiology, June 1, 2007; 144(2): 1144 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
K.-C. Kim, B. Fan, and Z. Chen
Pathogen-Induced Arabidopsis WRKY7 Is a Transcriptional Repressor and Enhances Plant Susceptibility to Pseudomonas syringae
Plant Physiology, November 1, 2006; 142(3): 1180 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
T. E. Mishina and J. Zeier
The Arabidopsis Flavin-Dependent Monooxygenase FMO1 Is an Essential Component of Biologically Induced Systemic Acquired Resistance
Plant Physiology, August 1, 2006; 141(4): 1666 - 1675.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
X. Xu, C. Chen, B. Fan, and Z. Chen
Physical and Functional Interactions between Pathogen-Induced Arabidopsis WRKY18, WRKY40, and WRKY60 Transcription Factors
PLANT CELL, May 1, 2006; 18(5): 1310 - 1326.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. Bartsch, E. Gobbato, P. Bednarek, S. Debey, J. L. Schultze, J. Bautor, and J. E. Parker
Salicylic Acid-Independent ENHANCED DISEASE SUSCEPTIBILITY1 Signaling in Arabidopsis Immunity and Cell Death Is Regulated by the Monooxygenase FMO1 and the Nudix Hydrolase NUDT7
PLANT CELL, April 1, 2006; 18(4): 1038 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
K. Yoshioka, W. Moeder, H.-G. Kang, P. Kachroo, K. Masmoudi, G. Berkowitz, and D. F. Klessig
The Chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 Activates Multiple Pathogen Resistance Responses
PLANT CELL, March 1, 2006; 18(3): 747 - 763.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
V. Pegadaraju, C. Knepper, J. Reese, and J. Shah
Premature Leaf Senescence Modulated by the Arabidopsis PHYTOALEXIN DEFICIENT4 Gene Is Associated with Defense against the Phloem-Feeding Green Peach Aphid
Plant Physiology, December 1, 2005; 139(4): 1927 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. C. Diener and F. M. Ausubel
RESISTANCE TO FUSARIUM OXYSPORUM 1, a Dominant Arabidopsis Disease-Resistance Gene, Is Not Race Specific
Genetics, September 1, 2005; 171(1): 305 - 321.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
B. J. Feys, M. Wiermer, R. A. Bhat, L. J. Moisan, N. Medina-Escobar, C. Neu, A. Cabral, and J. E. Parker
Arabidopsis SENESCENCE-ASSOCIATED GENE101 Stabilizes and Signals within an ENHANCED DISEASE SUSCEPTIBILITY1 Complex in Plant Innate Immunity
PLANT CELL, September 1, 2005; 17(9): 2601 - 2613.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
A. Coego, V. Ramirez, M. J. Gil, V. Flors, B. Mauch-Mani, and P. Vera
An Arabidopsis Homeodomain Transcription Factor, OVEREXPRESSOR OF CATIONIC PEROXIDASE 3, Mediates Resistance to Infection by Necrotrophic Pathogens
PLANT CELL, July 1, 2005; 17(7): 2123 - 2137.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
D. Tang, K. M. Christiansen, and R. W. Innes
Regulation of Plant Disease Resistance, Stress Responses, Cell Death, and Ethylene Signaling in Arabidopsis by the EDR1 Protein Kinase
Plant Physiology, June 1, 2005; 138(2): 1018 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
Z. Huang, J. M. Yeakley, E. W. Garcia, J. D. Holdridge, J.-B. Fan, and S. A. Whitham
Salicylic Acid-Dependent Expression of Host Genes in Compatible Arabidopsis-Virus Interactions
Plant Physiology, March 1, 2005; 137(3): 1147 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
T. Eulgem, V. J. Weigman, H.-S. Chang, J. M. McDowell, E. B. Holub, J. Glazebrook, T. Zhu, and J. L. Dangl
Gene Expression Signatures from Three Genetically Separable Resistance Gene Signaling Pathways for Downy Mildew Resistance
Plant Physiology, June 1, 2004; 135(2): 1129 - 1144.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
X. Dong
The Role of Membrane-Bound Ankyrin-Repeat Protein ACD6 in Programmed Cell Death and Plant Defense
Sci. Signal., February 24, 2004; 2004(221): pe6 - pe6.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. T. Song, H. Lu, and J. T. Greenberg
Divergent Roles in Arabidopsis thaliana Development and Defense of Two Homologous Genes, ABERRANT GROWTH AND DEATH2 and AGD2-LIKE DEFENSE RESPONSE PROTEIN1, Encoding Novel Aminotransferases
PLANT CELL, February 1, 2004; 16(2): 353 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
H. Suzuki, Y. Xia, R. Cameron, G. Shadle, J. Blount, C. Lamb, and R. A. Dixon
Signals for local and systemic responses of plants to pathogen attack
J. Exp. Bot., January 2, 2004; 55(395): 169 - 179.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Lu, D. N. Rate, J. T. Song, and J. T. Greenberg
ACD6, a Novel Ankyrin Protein, Is a Regulator and an Effector of Salicylic Acid Signaling in the Arabidopsis Defense Response
PLANT CELL, October 1, 2003; 15(10): 2408 - 2420.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. C.M. van Wees, H.-S. Chang, T. Zhu, and J. Glazebrook
Characterization of the Early Response of Arabidopsis to Alternaria brassicicola Infection Using Expression Profiling
Plant Physiology, June 1, 2003; 132(2): 606 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Cooper, J. D. Clarke, P. Budworth, J. Kreps, D. Hutchison, S. Park, S. Guimil, M. Dunn, P. Luginbuhl, C. Ellero, et al.
A network of rice genes associated with stress response and seed development
PNAS, April 15, 2003; 100(8): 4945 - 4950.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Tao, Z. Xie, W. Chen, J. Glazebrook, H.-S. Chang, B. Han, T. Zhu, G. Zou, and F. Katagiri
Quantitative Nature of Arabidopsis Responses during Compatible and Incompatible Interactions with the Bacterial Pathogen Pseudomonas syringae
PLANT CELL, February 1, 2003; 15(2): 317 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. Cui, G. Jander, L. R. Racki, P. D. Kim, N. E. Pierce, and F. M. Ausubel
Signals Involved in Arabidopsis Resistance to Trichoplusia ni Caterpillars Induced by Virulent and Avirulent Strains of the Phytopathogen Pseudomonas syringae
Plant Physiology, June 1, 2002; 129(2): 551 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
W. Chen, N. J. Provart, J. Glazebrook, F. Katagiri, H.-S. Chang, T. Eulgem, F. Mauch, S. Luan, G. Zou, S. A. Whitham, et al.
Expression Profile Matrix of Arabidopsis Transcription Factor Genes Suggests Their Putative Functions in Response to Environmental Stresses
PLANT CELL, March 1, 2002; 14(3): 559 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
P. Brodersen, M. Petersen, H. M. Pike, B. Olszak, S. Skov, N. Odum, L. B. Jorgensen, R. E. Brown, and J. Mundy
Knockout of Arabidopsis ACCELERATED-CELL-DEATH11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense
Genes & Dev., February 15, 2002; 16(4): 490 - 502.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. Nawrath, S. Heck, N. Parinthawong, and J.-P. Metraux
EDS5, an Essential Component of Salicylic Acid-Dependent Signaling for Disease Resistance in Arabidopsis, Is a Member of the MATE Transporter Family
PLANT CELL, January 1, 2002; 14(1): 275 - 286.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. Rusterucci, D. H. Aviv, B. F. Holt III, J. L. Dangl, and J. E. Parker
The Disease Resistance Signaling Components EDS1 and PAD4 Are Essential Regulators of the Cell Death Pathway Controlled by LSD1 in Arabidopsis
PLANT CELL, October 1, 2001; 13(10): 2211 - 2224.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
T. Genoud, M. B. Trevino Santa Cruz, and J.-P. Metraux
Numeric Simulation of Plant Signaling Networks
Plant Physiology, August 1, 2001; 126(4): 1430 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. A. Frye, D. Tang, and R. W. Innes
Negative regulation of defense responses in plants by a conserved MAPKK kinase
PNAS, December 8, 2000; (2000) 11405198.
[Abstract] [Full Text]

Home page
 Plant CellHome page
E. Mayda, B. Mauch-Mani, and P. Vera
Arabidopsis dth9 Mutation Identifies a Gene Involved in Regulating Disease Susceptibility without Affecting Salicylic Acid-Dependent Responses
PLANT CELL, November 1, 2000; 12(11): 2119 - 2128.
[Abstract] [Full Text]

Home page
 Plant CellHome page
J. D. Clarke, S. M. Volko, H. Ledford, F. M. Ausubel, and X. Dong
Roles of Salicylic Acid, Jasmonic Acid, and Ethylene in cpr-Induced Resistance in Arabidopsis
PLANT CELL, November 1, 2000; 12(11): 2175 - 2190.
[Abstract] [Full Text]

Home page
 Plant CellHome page
J. M. Stone, J. E. Heard, T. Asai, and F. M. Ausubel
Simulation of Fungal-Mediated Cell Death by Fumonisin B1 and Selection of Fumonisin B1-Resistant (fbr) Arabidopsis Mutants
PLANT CELL, October 1, 2000; 12(10): 1811 - 1822.
[Abstract] [Full Text]

Home page
 Plant CellHome page
T. Asai, J. M. Stone, J. E. Heard, Y. Kovtun, P. Yorgey, J. Sheen, and F. M. Ausubel
Fumonisin B1-Induced Cell Death in Arabidopsis Protoplasts Requires Jasmonate-, Ethylene-, and Salicylate-Dependent Signaling Pathways
PLANT CELL, October 1, 2000; 12(10): 1823 - 1836.
[Abstract] [Full Text]

Home page
 GeneticsHome page
J. T. Greenberg, F. P. Silverman, and H. Liang
Uncoupling Salicylic Acid-Dependent Cell Death and Defense-Related Responses From Disease Resistance in the Arabidopsis Mutant acd5
Genetics, September 1, 2000; 156(1): 341 - 350.
[Abstract] [Full Text]

Home page
 Plant CellHome page
N. Zhou, T. L. Tootle, and J. Glazebrook
Arabidopsis PAD3, a Gene Required for Camalexin Biosynthesis, Encodes a Putative Cytochrome P450 Monooxygenase
PLANT CELL, December 1, 1999; 11(12): 2419 - 2428.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Jirage, T. L. Tootle, T. L. Reuber, L. N. Frost, B. J. Feys, J. E. Parker, F. M. Ausubel, and J. Glazebrook
Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling
PNAS, November 9, 1999; 96(23): 13583 - 13588.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
L. Noël, T. L. Moores, E. A. van der Biezen, M. Parniske, M. J. Daniels, J. E. Parker, and J. D. G. Jones
Pronounced Intraspecific Haplotype Divergence at the RPP5 Complex Disease Resistance Locus of Arabidopsis
PLANT CELL, November 1, 1999; 11(11): 2099 - 2112.
[Abstract] [Full Text]

Home page
 Microbiol. Mol. Biol. Rev.Home page
J. P. Morrissey and A. E. Osbourn
Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis
Microbiol. Mol. Biol. Rev., September 1, 1999; 63(3): 708 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
D. N. Rate, J. V. Cuenca, G. R. Bowman, D. S. Guttman, and J. T. Greenberg
The Gain-of-Function Arabidopsis acd6 Mutant Reveals Novel Regulation and Function of the Salicylic Acid Signaling Pathway in Controlling Cell Death, Defenses, and Cell Growth
PLANT CELL, September 1, 1999; 11(9): 1695 - 1708.
[Abstract] [Full Text]

Home page
 Plant CellHome page
C. Nawrath and J.-P. Métraux
Salicylic Acid Induction–Deficient Mutants of Arabidopsis Express PR-2 and PR-5 and Accumulate High Levels of Camalexin after Pathogen Inoculation
PLANT CELL, August 1, 1999; 11(8): 1393 - 1404.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. A. Frye, D. Tang, and R. W. Innes
From the Cover: Negative regulation of defense responses in plants by a conserved MAPKK kinase
PNAS, January 2, 2001; 98(1): 373 - 378.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
L. Onate-Sanchez and K. B. Singh
Identification of Arabidopsis Ethylene-Responsive Element Binding Factors with Distinct Induction Kinetics after Pathogen Infection
Plant Physiology, April 1, 2002; 128(4): 1313 - 1322.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 1998 by the American Society of Plant Biologists