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Plant Cell, Vol. 11, 393-406, March 1999, Copyright © 1999, American Society of Plant Physiologists

The CLAVATA1 Receptor-like Kinase Requires CLAVATA3 for Its Assembly into a Signaling Complex That Includes KAPP and a Rho-Related Protein

Amy E. Trotochauda, Tong Haoa, Guang Wub, Zhenbiao Yangb, and Steven E. Clarka
a Department of Biology, University of Michigan, Ann Arbor, Michigan 48109-1048
b Plant Biotechnology Center, Ohio State University, Columbus, Ohio 43210

Correspondence to: Steven E. Clark, clarks{at}umich.edu (E-mail), 734-647-0884 (fax)

The CLAVATA1 (CLV1) and CLAVATA3 (CLV3) genes are required to maintain the balance between cell proliferation and organ formation at the Arabidopsis shoot and flower meristems. CLV1 encodes a receptor-like protein kinase. We have found that CLV1 is present in two protein complexes in vivo. One is ~185 kD, and the other is ~450 kD. In each complex, CLV1 is part of a disulfide-linked multimer of ~185 kD. The 450-kD complex contains the protein phosphatase KAPP, which is a negative regulator of CLV1 signaling, and a Rho GTPase–related protein. In clv1 and clv3 mutants, CLV1 is found primarily in the 185-kD complex. We propose that CLV1 is present as an inactive disulfide-linked heterodimer and that CLV3 functions to promote the assembly of the active 450-kD complex, which then relays signal transduction through a Rho GTPase.


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