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Plant Cell, Vol. 11, 1695-1708, September 1999, Copyright © 1999, American Society of Plant Physiologists

The Gain-of-Function Arabidopsis acd6 Mutant Reveals Novel Regulation and Function of the Salicylic Acid Signaling Pathway in Controlling Cell Death, Defenses, and Cell Growth

Debra N. Ratea, James V. Cuencab, Grant R. Bowmanb, David S. Guttmanb, and Jean T. Greenbergb
a Chemistry and Biochemistry Graduate Program, University of Colorado at Boulder, Boulder, Colorado 80309
b Department of Molecular Genetics and Cell Biology, University of Chicago, 1103 East 57th Street, Chicago, Illinois 60637

Correspondence to: Jean T. Greenberg, jgreenbe{at}midway.uchicago.edu (E-mail), 773-702-9270 (fax)

We isolated a dominant gain-of-function Arabidopsis mutant, accelerated cell death 6 (acd6), with elevated defenses, patches of dead and enlarged cells, reduced stature, and increased resistance to Pseudomonas syringae. The acd6-conferred phenotypes are suppressed by removing a key signaling molecule, salicylic acid (SA), by using the nahG transgene, which encodes SA hydroxylase. This suppression includes phenotypes that are not induced by application of SA to wild-type plants, indicating that SA acts with a second signal to cause many acd6-conferred phenotypes. acd6–nahG plants show hyperactivation of all acd6-conferred phenotypes after treatment with a synthetic inducer of the SA pathway, benzo(1,2,3)thiadiazole-7-carbothioic acid (BTH), suggesting that SA acts with and also modulates the levels and/or activity of the second defense signal. acd6 acts partially through a NONEXPRESSOR OF PR 1 (NPR1) gene–independent pathway that activates defenses and confers resistance to P. syringae. Surprisingly, BTH-treated acd6–nahG plants develop many tumor-like abnormal growths, indicating a possible role for SA in modulating cell growth.




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