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Plant Cell, Vol. 12, 97-110, January 2000, Copyright © 2000, American Society of Plant Physiologists

The ROOT MERISTEMLESS1/CADMIUM SENSITIVE2 Gene Defines a Glutathione-Dependent Pathway Involved in Initiation and Maintenance of Cell Division during Postembryonic Root Development

Teva Vernouxa, Robert C. Wilsonb, Kevin A. Seeleyb, Jean-Philippe Reichhelda, Sandra Muroyb, Spencer Brownc, Spencer C. Maughand, Christopher S. Cobbettd, Marc Van Montagua, Dirk Inzéa, Mike J. Maya, and Zinmay R. Sungb
a Universiteit Gent, K.L. Ledeganckstraat 35, B-9000, Gent, Belgium
b Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, California 94720
c Institut des Sciences du Végétal-CNRS, Service de Cytométrie, avenue de la Terrasse, 91198 Gif-sur-Yvette, France
d Department of Genetics, University of Melbourne, Parkville 3052, Australia

Correspondence to: Zinmay R. Sung, zrsung{at}nature.berkeley.edu (E-mail), 510-642-4995 (fax)

Activation of cell division in the root apical meristem after germination is essential for postembryonic root development. Arabidopsis plants homozygous for a mutation in the ROOT MERISTEMLESS1 (RML1) gene are unable to establish an active postembryonic meristem in the root apex. This mutation abolishes cell division in the root but not in the shoot. We report the molecular cloning of the RML1 gene, which encodes the first enzyme of glutathione (GSH) biosynthesis, {gamma}-glutamylcysteine synthetase, and which is allelic to CADMIUM SENSITIVE2. The phenotype of the rml1 mutant, which was also evident in the roots of wild-type Arabidopsis and tobacco treated with an inhibitor of GSH biosynthesis, could be relieved by applying GSH to rml1 seedlings. By using a synchronized tobacco cell suspension culture, we showed that the G1-to-S phase transition requires an adequate level of GSH. These observations suggest the existence of a GSH-dependent developmental pathway essential for initiation and maintenance of cell division during postembryonic root development.




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