Plant Cell Journal of Pharmacology and Experimental Therapeutics
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Plant Cell, Vol. 12, 519-534, April 2000, Copyright © 2000, American Society of Plant Physiologists

A Role for Ectophosphatase in Xenobiotic Resistance

Collin Thomasa, Asha Rajagopala, Brian Windsora, Robert Dudlerb, Alan Lloyda, and Stanley J. Rouxa
a Section of Molecular Cell and Developmental Biology, Biological Laboratories 311, University of Texas at Austin, Austin, Texas 78713
b Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, CH-8008 Zurich, Switzerland

Correspondence to: Stanley J. Roux, sroux{at}uts.cc.utexas.edu (E-mail), 512-232-3402 (fax)

Xenobiotic resistance in animals, plants, yeast, and bacteria is known to involve ATP binding cassette transporters that efflux invading toxins. We present data from yeast and a higher plant indicating that xenobiotic resistance also involves extracellular ATP degradation. Transgenic upregulation of ecto-ATPase alone confers resistance to organisms that have had no previous exposure to toxins. Similarly, cells that are deficient in extracellular ATPase activity are more sensitive to xenobiotics. On the basis of these and other supporting data, we hypothesize that the hydrolysis of extracellular ATP by phosphatases and ATPases may be necessary for the resistance conferred by P-glycoprotein.




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