Plant Cell SoftGenetics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (81)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Luck, J. E.
Right arrow Articles by Ellis, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luck, J. E.
Right arrow Articles by Ellis, J. G.
Agricola
Right arrow Articles by Luck, J. E.
Right arrow Articles by Ellis, J. G.
Plant Cell, Vol. 12, 1367-1378, August 2000, Copyright © 2000, American Society of Plant Physiologists

Regions outside of the Leucine-Rich Repeats of Flax Rust Resistance Proteins Play a Role in Specificity Determination

Joanne E. Lucka, Gregory J. Lawrenceb, Peter N. Doddsb, Kenneth W. Shepherdc, and Jeffrey G. Ellisb
a Cooperative Research Center for Plant Science, GPO Box 475, Canberra, ACT, 2601, Australia
b Commonwealth Scientific and Industrial Research Organization–Plant Industry, GPO Box 1600, Canberra, ACT, 2601, Australia
c Department of Plant Science, Waite Campus, University of Adelaide, PMB 1, Glen Osmond, South Australia, 5064, Australia

Correspondence to: Jeffrey G. Ellis, jeff.ellis{at}pi.csiro.au (E-mail), 61-2-6246-5000 (fax)

Multiple alleles controlling different gene-for-gene flax rust resistance specificities occur at the L locus of flax. At least three distinct regions can be recognized in the predicted protein products: the Toll/interleukin-1 receptor homology (TIR) region, a nucleotide binding site (NBS) region, and a leucine-rich repeat (LRR) region. Replacement of the TIR-encoding region of the L6 allele with the corresponding regions of L2 or LH by recombination changed the specificity of the allele from L6 to L7. Replacement of the TIR and most of the NBS-encoding region of L10 with the equivalent region of L2 or L9 generated recombinant alleles having a novel specificity. However, replacement of the L10 TIR-encoding region with the TIR-encoding region of L2 gave rise to an allele with no detectable specificity. These data indicate that non-LRR regions can determine specificity differences between allelic gene products and that functional specificity involves interactions between coadapted polymorphic regions in the protein products of the alleles. Evidence for the action of diversifying selection on the TIR region is observed.




This article has been cited by other articles:


Home page
 GeneticsHome page
Q. Xu, X. Wen, and X. Deng
Genomic Organization, Rapid Evolution and Meiotic Instability of Nucleotide-Binding-Site-Encoding Genes in a New Fruit Crop, "Chestnut Rose"
Genetics, April 1, 2008; 178(4): 2081 - 2091.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
Y. Cao, X. Ding, M. Cai, J. Zhao, Y. Lin, X. Li, C. Xu, and S. Wang
The Expression Pattern of a Rice Disease Resistance Gene Xa3/Xa26 Is Differentially Regulated by the Genetic Backgrounds and Developmental Stages That Influence Its Function
Genetics, September 1, 2007; 177(1): 523 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C.-I A. Wang, G. Guncar, J. K. Forwood, T. Teh, A.-M. Catanzariti, G. J. Lawrence, F. E. Loughlin, J. P. Mackay, H. J. Schirra, P. A. Anderson, et al.
Crystal Structures of Flax Rust Avirulence Proteins AvrL567-A and -D Reveal Details of the Structural Basis for Flax Disease Resistance Specificity
PLANT CELL, September 1, 2007; 19(9): 2898 - 2912.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
T. M. Burch-Smith and S. P. Dinesh-Kumar
The Functions of Plant TIR Domains
Sci. Signal., August 28, 2007; 2007(401): pe46 - pe46.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
E. G. Bakker, C. Toomajian, M. Kreitman, and J. Bergelson
A Genome-Wide Survey of R Gene Polymorphisms in Arabidopsis
PLANT CELL, August 1, 2006; 18(8): 1803 - 1818.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. Qu, G. Liu, B. Zhou, M. Bellizzi, L. Zeng, L. Dai, B. Han, and G.-L. Wang
The Broad-Spectrum Blast Resistance Gene Pi9 Encodes a Nucleotide-Binding Site-Leucine-Rich Repeat Protein and Is a Member of a Multigene Family in Rice
Genetics, March 1, 2006; 172(3): 1901 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
X. Sun, Y. Cao, and S. Wang
Point Mutations with Positive Selection Were a Major Force during the Evolution of a Receptor-Kinase Resistance Gene Family of Rice
Plant Physiology, March 1, 2006; 140(3): 998 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
F. C. Lanfermeijer, J. Warmink, and J. Hille
The products of the broken Tm-2 and the durable Tm-22 resistance genes from tomato differ in four amino acids
J. Exp. Bot., November 1, 2005; 56(421): 2925 - 2933.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
P. Srichumpa, S. Brunner, B. Keller, and N. Yahiaoui
Allelic Series of Four Powdery Mildew Resistance Genes at the Pm3 Locus in Hexaploid Bread Wheat
Plant Physiology, October 1, 2005; 139(2): 885 - 895.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
A. Al-Daoude, M. de Torres Zabala, J.-H. Ko, and M. Grant
RIN13 Is a Positive Regulator of the Plant Disease Resistance Protein RPM1
PLANT CELL, March 1, 2005; 17(3): 1016 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Kuang, S.-S. Woo, B. C. Meyers, E. Nevo, and R. W. Michelmore
Multiple Genetic Processes Result in Heterogeneous Rates of Evolution within the Major Cluster Disease Resistance Genes in Lettuce
PLANT CELL, November 1, 2004; 16(11): 2870 - 2894.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
B. B. H. Wulff, C. M. Thomas, M. Parniske, and J. D. G. Jones
Genetic Variation at the Tomato Cf-4/Cf-9 Locus Induced by EMS Mutagenesis and Intralocus Recombination
Genetics, May 1, 2004; 167(1): 459 - 470.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. E. Rose, P. D. Bittner-Eddy, C. H. Langley, E. B. Holub, R. W. Michelmore, and J. L. Beynon
The Maintenance of Extreme Amino Acid Diversity at the Disease Resistance Gene, RPP13, in Arabidopsis thaliana
Genetics, March 1, 2004; 166(3): 1517 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
P. N. Dodds, G. J. Lawrence, A.-M. Catanzariti, M. A. Ayliffe, and J. G. Ellis
The Melampsora lini AvrL567 Avirulence Genes Are Expressed in Haustoria and Their Products Are Recognized inside Plant Cells
PLANT CELL, March 1, 2004; 16(3): 755 - 768.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Feuillet, S. Travella, N. Stein, L. Albar, A. Nublat, and B. Keller
Map-based isolation of the leaf rust disease resistance gene Lr10 from the hexaploid wheat (Triticum aestivum L.) genome
PNAS, December 9, 2003; 100(25): 15253 - 15258.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Deslandes, J. Olivier, N. Peeters, D. X. Feng, M. Khounlotham, C. Boucher, I. Somssich, S. Genin, and Y. Marco
Physical interaction between RRS1-R, a protein conferring resistance to bacterial wilt, and PopP2, a type III effector targeted to the plant nucleus
PNAS, June 24, 2003; 100(13): 8024 - 8029.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
B. C. Meyers, A. Kozik, A. Griego, H. Kuang, and R. W. Michelmore
Genome-Wide Analysis of NBS-LRR-Encoding Genes in Arabidopsis
PLANT CELL, April 1, 2003; 15(4): 809 - 834.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Q.-H. Shen, F. Zhou, S. Bieri, T. Haizel, K. Shirasu, and P. Schulze-Lefert
Recognition Specificity and RAR1/SGT1 Dependence in Barley Mla Disease Resistance Genes to the Powdery Mildew Fungus
PLANT CELL, March 1, 2003; 15(3): 732 - 744.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
R. Mauricio, E. A. Stahl, T. Korves, D. Tian, M. Kreitman, and J. Bergelson
Natural Selection for Polymorphism in the Disease Resistance Gene Rps2 of Arabidopsis thaliana
Genetics, February 1, 2003; 163(2): 735 - 746.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Horvath, N. Rostoks, R. Brueggeman, B. Steffenson, D. von Wettstein, and A. Kleinhofs
Genetically engineered stem rust resistance in barley using the Rpg1 gene
PNAS, January 7, 2003; 100(1): 364 - 369.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. Bai, L. A. Pennill, J. Ning, S. W. Lee, J. Ramalingam, C. A. Webb, B. Zhao, Q. Sun, J. C. Nelson, J. E. Leach, et al.
Diversity in Nucleotide Binding Site-Leucine-Rich Repeat Genes in Cereals
Genome Res., December 1, 2002; 12(12): 1871 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. A. Graham, L. F. Marek, and R. C. Shoemaker
Organization, Expression and Evolution of a Disease Resistance Gene Cluster in Soybean
Genetics, December 1, 2002; 162(4): 1961 - 1977.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M. Mondragon-Palomino, B. C. Meyers, R. W. Michelmore, and B. S. Gaut
Patterns of Positive Selection in the Complete NBS-LRR Gene Family of Arabidopsis thaliana
Genome Res., September 1, 2002; 12(9): 1305 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
P. Tornero, R. A. Chao, W. N. Luthin, S. A. Goff, and J. L. Dangl
Large-Scale Structure -Function Analysis of the Arabidopsis RPM1 Disease Resistance Protein
PLANT CELL, February 1, 2002; 14(2): 435 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
R. Fluhr
Sentinels of Disease. Plant Resistance Genes
Plant Physiology, December 1, 2001; 127(4): 1367 - 1374.
[Full Text] [PDF]

Home page
 ScienceHome page
J. Bergelson, M. Kreitman, E. A. Stahl, and D. Tian
Evolutionary Dynamics of Plant R-Genes
Science, June 22, 2001; 292(5525): 2281 - 2285.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
Q. Sun, N. C. Collins, M. Ayliffe, S. M. Smith, J. Drake, T. Pryor, and S. H. Hulbert
Recombination Between Paralogues at the rp1 Rust Resistance Locus in Maize
Genetics, May 1, 2001; 158(1): 423 - 438.
[Abstract] [Full Text]

Home page
 GeneticsHome page
D. Banerjee, X. Zhang, and A. F. Bent
The Leucine-Rich Repeat Domain Can Determine Effective Interaction Between RPS2 and Other Host Factors in Arabidopsis RPS2-Mediated Disease Resistance
Genetics, May 1, 2001; 158(1): 439 - 450.
[Abstract] [Full Text]

Home page
 ScienceHome page
S. Xiao, S. Ellwood, O. Calis, E. Patrick, T. Li, M. Coleman, and J. G. Turner
Broad-Spectrum Mildew Resistance in Arabidopsis thaliana Mediated by RPW8
Science, January 5, 2001; 291(5501): 118 - 120.
[Abstract] [Full Text]

Home page
 Plant CellHome page
P. N. Dodds, G. J. Lawrence, and J. G. Ellis
Six Amino Acid Changes Confined to the Leucine-Rich Repeat {beta}-Strand/{beta}-Turn Motif Determine the Difference between the P and P2 Rust Resistance Specificities in Flax
PLANT CELL, January 1, 2001; 13(1): 163 - 178.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2000 by the American Society of Plant Biologists