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Plant Cell, Vol. 13, 89-100, January 2001, Copyright © 2001, American Society of Plant Physiologists

A Mutation of the Mitochondrial ABC Transporter Sta1 Leads to Dwarfism and Chlorosis in the Arabidopsis Mutant starik

Sergei Kushnira, Elena Babiychuka, Sergei Storozhenkoa, Mark W. Daveya, Jutta Papenbrockb, Riet De Ryckea, Gilbert Englerc, Udo W. Stephand, Heike Langee, Gyula Kispale, Roland Lille, and Marc Van Montagua
a Vakgroep Moleculaire Genetica and Departement Plantengenetica, Vlaams Interuniversitair Instituut voor Biotechnologie (VIB), Universiteit Gent, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium
b Institut für Botanik, Universität Hannover, Herrenhäuserstrasse 2, D-30419 Hannover, Germany
c Laboratoire Associé de l'Institut National de la Recherche Agronomique (France), Universiteit Gent, B-9000 Gent, Belgium
d Group of Molecular Mineral Assimilation, Institut für Pflanzengenetik und Kulturpflanzenforschung, Correnstrasse 3, D-06466 Gatersleben, Germany
e Institut für Zytobiologie und Zytopathologie der Philipps-Universität Marburg, Robert-Koch-Strasse 5, D-35033 Marburg, Germany

Correspondence to: Sergei Kushnir, sekus{at}gengenp.rug.ac.be (E-mail), 32-9-264-5349 (fax)

A mutation in the Arabidopsis gene STARIK leads to dwarfism and chlorosis of plants with an altered morphology of leaf and cell nuclei. We show that the STARIK gene encodes the mitochondrial ABC transporter Sta1 that belongs to a subfamily of Arabidopsis half-ABC transporters. The severity of the starik phenotype is suppressed by the ectopic expression of the STA2 homolog; thus, Sta1 function is partially redundant. Sta1 supports the maturation of cytosolic Fe/S protein in {Delta}atm1 yeast, substituting for the ABC transporter Atm1p. Similar to Atm1p-deficient yeast, mitochondria of the starik mutant accumulated more nonheme, nonprotein iron than did wild-type organelles. We further show that plant mitochondria contain a putative L-cysteine desulfurase. Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.




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