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The Plant Cell, Vol. 14, 2495-2507, October 2002, Copyright © 2002,
American Society of Plant Biologists

A Tumor Suppressor Homolog, AtPTEN1, Is Essential for Pollen Development in Arabidopsis

Rajeev Gupta1, Julie T. L. Ting1, Lubomir N. Sokolov, Sheila A. Johnson and Sheng Luan2

Department of Plant and Microbial Biology, University of California, Berkeley, California 94720

2 To whom correspondence should be addressed. E-mail sluan{at}nature.berkeley.edu; fax 510-642-4995

Although it is well known that Tyr phosphatases play a critical role in signal transduction in animal cells, little is understood of the functional significance of Tyr phosphatases in higher plants. Here, we describe the functional analysis of an Arabidopsis gene (AtPTEN1) that encodes a Tyr phosphatase closely related to PTEN, a tumor suppressor in animals. The recombinant AtPTEN1 protein, like its homologs in animals, is an active phosphatase that dephosphorylates phosphotyrosine and phosphatidylinositol substrates. RNA gel blot analysis and examination of promoter-reporter constructs in transgenic Arabidopsis plants revealed that the AtPTEN1 gene is expressed exclusively in pollen grains during the late stage of development. Suppression of AtPTEN1 gene expression by RNA interference caused pollen cell death after mitosis. We conclude that AtPTEN1 is a pollen-specific phosphatase and is essential for pollen development.




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