First published online February 19, 2002; 10.1105/tpc.010373
The Plant Cell, Vol. 14, 407-420,
February 2002, Copyright © 2002,
American Society of Plant Biologists
Independently Regulated Neocentromere Activity of Two Classes of Tandem Repeat Arrays
Evelyn N. Hiatta,
Edward K. Kentnera and
R. Kelly Dawe1,a,b
a Department of Genetics, University of Georgia, Athens, Georgia 30602
b Department of Botany, University of Georgia, Athens, Georgia 30602
1 To whom correspondence should be addressed. E-mail kelly{at}dogwood.botany.uga.edu; fax 706-542-1805
Tandem repeat arrays often are found in interstitial (i.e., normally gene-rich) regions on chromosomes. In maize, genes on abnormal chromosome 10 induce the tandem repeats that make up knobs to move poleward on the meiotic spindle. This so-called neocentromere activity results in the preferential recovery, or meiotic drive, of the knobs in progeny. Here we show that two classes of repeats differ in their capacity to form neocentromeres and that their motility is controlled in trans by at least two repeat-specific activators. Microtubule dynamics appear to contribute little to the movement of neocentromeres (they are active in the presence of taxol), suggesting that the mechanism of motility involves microtubule-based motors. These data suggest that maize knob repeats and their binding proteins have coevolved to ensure their preferential recovery in progeny. Neocentromere-mediated drive provides a plausible mechanism for the evolution and maintenance of repeat arrays that occur in interstitial positions.
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