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First published online May 2, 2002; 10.1105/tpc.001123

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The Plant Cell, Vol. 14, 993-1003, May 2002, Copyright © 2002,
American Society of Plant Biologists

Arabidopsis SGT1b Is Required for Defense Signaling Conferred by Several Downy Mildew Resistance Genes

Mahmut Töra, Pam Gordona, Alayne Cuzick1,a, Thomas Eulgemb, Evaggelia Sinapidou2,a, Figen Mert-Türk3,a, Canan Canc, Jeffery L. Danglb,d and Eric B. Holub4,a

a Plant Genetics and Biotechnology Department, Horticulture Research International, Wellesbourne, Warwick CV35 9EF, United Kingdom
b Department of Biology, Coker Hall, University of North Carolina, Chapel Hill, North Carolina 27599-3280
c Department of Biological Sciences, Gaziantep University, Gaziantep 27310, Turkey
d Department of Microbiology and Immunology, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280

4 To whom correspondence should be addressed. E-mail eric.holub{at}hri.ac.uk; fax 1789-470-552

We describe the identification of a mutant in the Arabidopsis accession Columbia (Col-0) that exhibits enhanced downy mildew (edm1) susceptibility to several Peronospora parasitica isolates, including the RPP7-diagnostic isolate Hiks1. The mutation was mapped to chromosome IV and characterized physically as a 35-kb deletion spanning seven genes. One of these genes complemented the mutant to full wild-type resistance against all of the Peronospora isolates tested. This gene (AtSGT1b) encodes a predicted protein of 39.8 kD and is an Arabidopsis ortholog of yeast SGT1, which was described originally as a key regulatory protein in centromere function and ubiquitin-mediated proteolysis. AtSGT1b contains three tetratricopeptide repeats at the N terminus followed by a bipartite chord-containing SGT domain and an SGT-specific domain at the C terminus. We discuss the role of AtSGT1b in disease resistance and its possible involvement in ubiquitin-mediated proteolysis in plants.




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