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First published online August 23, 2002; 10.1105/tpc.002337

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The Plant Cell, Vol. 14, 2059-2069, September 2002, Copyright © 2002,
American Society of Plant Biologists

Double Jeopardy

Both Overexpression and Suppression of a Redox-Activated Plant Mitogen-Activated Protein Kinase Render Tobacco Plants Ozone Sensitive

Marcus A. Samuel and Brian E. Ellis1

Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, V6T 1Z3 Canada

1 To whom correspondence should be addressed. E-mail bee{at}interchange.ubc.ca; fax 604-822-2114

In plants, the role of mitogen-activated protein kinase (MAPK) in reactive oxygen species (ROS)–based signal transduction processes is elusive. Despite the fact that ROS can induce MAPK activation, no direct genetic evidence has linked ROS-induced MAPK activation with the hypersensitive response, a form of programmed cell death. In tobacco, the major ROS-induced MAPK is salicylate-induced protein kinase (SIPK). We found through gain-of-function and loss-of-function approaches that both overexpression and RNA interference–based suppression of SIPK render the plant sensitive to ROS stress. Transgenic lines overexpressing a nonphosphorylatable version of SIPK were not ROS sensitive. Analysis of the MAPK activation profiles in ROS-stressed transgenic and wild-type plants revealed a striking interplay between SIPK and another MAPK (wound-induced protein kinase [WIPK]) in the different kinotypes. During continuous ozone exposure, abnormally prolonged activation of SIPK was seen in the SIPK-overexpression genotype, without WIPK activation, whereas strong and stable activation of WIPK was observed in the SIPK-suppressed lines. Thus, one role of activated SIPK in tobacco cells upon ROS stimulation appears to be control of the inactivation of WIPK.




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