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First published online April 10, 2003; 10.1105/tpc.010827

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The Plant Cell, Vol. 15, 1120-1130, May 2003, Copyright © 2003,
American Society of Plant Biologists

The Arabidopsis SLEEPY1 Gene Encodes a Putative F-Box Subunit of an SCF E3 Ubiquitin Ligase

Karen M. McGinnis1,a, Stephen G. Thomasb, Jonathan D. Soulea, Lucia C. Straderc, Janice M. Zalea, Tai-ping Sunb and Camille M. Steber2,a

a United States Department of Agriculture–Agricultural Research Service, Washington State University, Pullman, Washington 99164-6420
b Department of Biology, Duke University, Durham, North Carolina 27708-1000
c Plant Physiology and Biochemistry, Washington State University, Pullman, Washington 99164-6420

2 To whom correspondence should be addressed. E-mail csteber{at}wsu.edu; fax 509-335-2553

The Arabidopsis SLY1 (SLEEPY1) gene positively regulates gibberellin (GA) signaling. Positional cloning of SLY1 revealed that it encodes a putative F-box protein. This result suggests that SLY1 is the F-box subunit of an SCF E3 ubiquitin ligase that regulates GA responses. The DELLA domain protein RGA (repressor of ga1-3) is a repressor of GA response that appears to undergo GA-stimulated protein degradation. RGA is a potential substrate of SLY1, because sly1 mutations cause a significant increase in RGA protein accumulation even after GA treatment. This result suggests SCFSLY1-targeted degradation of RGA through the 26S proteasome pathway. Further support for this model is provided by the observation that an rga null allele partially suppresses the sly1-10 mutant phenotype. The predicted SLY1 amino acid sequence is highly conserved among plants, indicating a key role in GA response.




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