This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 15/7/1619    most recent tpc.010009v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Elo, A. Articles by Mackenzie, S. A. Search for Related Content PubMed PubMed Citation Articles by Elo, A. Articles by Mackenzie, S. A. Agricola Articles by Elo, A. Articles by Mackenzie, S. A.

Nuclear Genes That Encode Mitochondrial Proteins for DNA and RNA Metabolism Are Clustered in the Arabidopsis Genome

^a Plant Science Initiative, Beadle Center for Genetics Research, University of Nebraska, Lincoln, Nebraska 68588-0660
^b Department of Biometry, University of Nebraska, Lincoln, Nebraska 68583-0712

² To whom correspondence should be addressed. E-mail smackenzie2{at}unl.edu; fax 402-472-3139

The plant mitochondrial genome is complex in structure, owing to a high degree of recombination activity that subdivides the genome and increases genetic variation. The replication activity of various portions of the mitochondrial genome appears to be nonuniform, providing the plant with an ability to modulate its mitochondrial genotype during development. These and other interesting features of the plant mitochondrial genome suggest that adaptive changes have occurred in DNA maintenance and transmission that will provide insight into unique aspects of plant mitochondrial biology and mitochondrial-chloroplast coevolution. A search in the Arabidopsis genome for genes involved in the regulation of mitochondrial DNA metabolism revealed a region of chromosome III that is unusually rich in genes for mitochondrial DNA and RNA maintenance. An apparently similar genetic linkage was observed in the rice genome. Several of the genes identified within the chromosome III interval appear to target the plastid or to be targeted dually to the mitochondria and the plastid, suggesting that the process of endosymbiosis likely is accompanied by an intimate coevolution of these two organelles for their genome maintenance functions.

This article has been cited by other articles:

				P. Boesch, N. Ibrahim, F. Paulus, A. Cosset, V. Tarasenko, and A. Dietrich Plant mitochondria possess a short-patch base excision DNA repair pathway Nucleic Acids Res., September 1, 2009; 37(17): 5690 - 5700. [Abstract] [Full Text] [PDF]

				B.-Y. Liao and J. Zhang Coexpression of Linked Genes in Mammalian Genomes Is Generally Disadvantageous Mol. Biol. Evol., August 1, 2008; 25(8): 1555 - 1565. [Abstract] [Full Text] [PDF]

				Y. Ono, A. Sakai, K. Takechi, S. Takio, M. Takusagawa, and H. Takano NtPolI-like1 and NtPolI-like2, Bacterial DNA Polymerase I Homologs Isolated from BY-2 Cultured Tobacco Cells, Encode DNA Polymerases Engaged in DNA Replication in Both Plastids and Mitochondria Plant Cell Physiol., December 1, 2007; 48(12): 1679 - 1692. [Abstract] [Full Text] [PDF]

				M. Ueda, S.-i. Arimura, M. P. Yamamoto, F. Takaiwa, N. Tsutsumi, and K.-i. Kadowaki Promoter Shuffling at a Nuclear Gene for Mitochondrial RPL27. Involvement of Interchromosome and Subsequent Intrachromosome Recombinations Plant Physiology, June 1, 2006; 141(2): 702 - 710. [Abstract] [Full Text] [PDF]

				A. C. Christensen, A. Lyznik, S. Mohammed, C. G. Elowsky, A. Elo, R. Yule, and S. A. Mackenzie Dual-Domain, Dual-Targeting Organellar Protein Presequences in Arabidopsis Can Use Non-AUG Start Codons PLANT CELL, October 1, 2005; 17(10): 2805 - 2816. [Abstract] [Full Text] [PDF]

				H. S. Cho, S. S. Lee, K. D. Kim, I. Hwang, J.-S. Lim, Y.-I. Park, and H.-S. Pai DNA Gyrase Is Involved in Chloroplast Nucleoid Partitioning PLANT CELL, October 1, 2004; 16(10): 2665 - 2682. [Abstract] [Full Text] [PDF]

				M. Taira, U. Valtersson, B. Burkhardt, and R. A. Ludwig Arabidopsis thaliana GLN2-Encoded Glutamine Synthetase Is Dual Targeted to Leaf Mitochondria and Chloroplasts PLANT CELL, August 1, 2004; 16(8): 2048 - 2058. [Abstract] [Full Text] [PDF]

				G. Blanc and K. H. Wolfe Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution PLANT CELL, July 1, 2004; 16(7): 1679 - 1691. [Abstract] [Full Text] [PDF]

				E. J.B. Williams and D. J. Bowles Coexpression of Neighboring Genes in the Genome of Arabidopsis thaliana Genome Res., June 1, 2004; 14(6): 1060 - 1067. [Abstract] [Full Text] [PDF]

				J. L. Heazlewood, J. S. Tonti-Filippini, A. M. Gout, D. A. Day, J. Whelan, and A. H. Millar Experimental Analysis of the Arabidopsis Mitochondrial Proteome Highlights Signaling and Regulatory Components, Provides Assessment of Targeting Prediction Programs, and Indicates Plant-Specific Mitochondrial Proteins PLANT CELL, January 1, 2004; 16(1): 241 - 256. [Abstract] [Full Text] [PDF]

				O. Chew, J. Whelan, and A. H. Millar Molecular Definition of the Ascorbate-Glutathione Cycle in Arabidopsis Mitochondria Reveals Dual Targeting of Antioxidant Defenses in Plants J. Biol. Chem., November 21, 2003; 278(47): 46869 - 46877. [Abstract] [Full Text] [PDF]