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First published online January 23, 2004; 10.1105/tpc.017384

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The Plant Cell 16:533-543 (2004)
© 2004 American Society of Plant Biologists

Aux/IAA Proteins Contain a Potent Transcriptional Repression Domain

Shiv B. Tiwari, Gretchen Hagen and Tom J. Guilfoyle1

Department of Biochemistry, University of Missouri, Columbia, Missouri 65211

1 To whom correspondence should be addressed. E-mail guilfoylet{at}missouri.edu; fax 573-882-5635.

Aux/IAA proteins are short-lived nuclear proteins that repress expression of primary/early auxin response genes in protoplast transfection assays. Repression is thought to result from Aux/IAA proteins dimerizing with auxin response factor (ARF) transcriptional activators that reside on auxin-responsive promoter elements, referred to as AuxREs. Most Aux/IAA proteins contain four conserved domains, designated domains I, II, III, and IV. Domain II and domains III and IV play roles in protein stability and dimerization, respectively. A clear function for domain I had not been established. Results reported here indicate that domain I in Aux/IAA proteins is an active repression domain that is transferable and dominant over activation domains. An LxLxL motif within domain I is important for conferring repression. The dominance of Aux/IAA repression domains over activation domains in ARF transcriptional activators provides a plausible explanation for the repression of auxin response genes via ARF-Aux/IAA dimerization on auxin-responsive promoters.




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