Plant Cell Illumina
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online February 18, 2004; 10.1105/tpc.018978

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
16/3/658    most recent
tpc.018978v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (109)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by To, J. P.C.
Right arrow Articles by Kieber, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by To, J. P.C.
Right arrow Articles by Kieber, J. J.
Agricola
Right arrow Articles by To, J. P.C.
Right arrow Articles by Kieber, J. J.
The Plant Cell 16:658-671 (2004)
© 2004 American Society of Plant Biologists

Type-A Arabidopsis Response Regulators Are Partially Redundant Negative Regulators of Cytokinin Signaling

Jennifer P.C. Toa,1, Georg Haberera,1,2, Fernando J. Ferreiraa, Jean Deruèrea, Michael G. Masonb,3, G. Eric Schallerb,3, Jose M. Alonsoc,4, Joseph R. Eckerc and Joseph J. Kiebera,5

a Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599
b Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham, New Hampshire 03824
c Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037

5 To whom correspondence should be addressed. E-mail jkieber{at}unc.edu; fax 919-962-1625.

Type-A Arabidopsis (Arabidopsis thaliana) response regulators (ARRs) are a family of 10 genes that are rapidly induced by cytokinin and are highly similar to bacterial two-component response regulators. We have isolated T-DNA insertions in six of the type-A ARRs and constructed multiple insertional mutants, including the arr3,4,5,6,8,9 hextuple mutant. Single arr mutants were indistinguishable from the wild type in various cytokinin assays; double and higher order arr mutants showed progressively increasing sensitivity to cytokinin, indicating functional overlap among type-A ARRs and that these genes act as negative regulators of cytokinin responses. The induction of cytokinin primary response genes was amplified in arr mutants, indicating that the primary response to cytokinin is affected. Spatial patterns of ARR gene expression were consistent with partially redundant function of these genes in cytokinin signaling. The arr mutants show altered red light sensitivity, suggesting a general involvement of type-A ARRs in light signal transduction. Further, morphological phenotypes of some arr mutants suggest complex regulatory interactions and gene-specific functions among family members.




This article has been cited by other articles:


Home page
 Mol PlantHome page
M. Morant, C. Ekstrom, P. Ulvskov, C. Kristensen, M. Rudemo, C. E. Olsen, J. Hansen, K. Jorgensen, B. Jorgensen, B. L. Moller, et al.
Metabolomic, Transcriptional, Hormonal, and Signaling Cross-Talk in Superroot2
Mol Plant, January 1, 2010; 3(1): 192 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
B. Pils and A. Heyl
Unraveling the Evolution of Cytokinin Signaling
Plant Physiology, October 1, 2009; 151(2): 782 - 791.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. P. Gordon, V. S. Chickarmane, C. Ohno, and E. M. Meyerowitz
Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristem
PNAS, September 22, 2009; 106(38): 16529 - 16534.
[Abstract] [Full Text] [PDF]

Home page
 DNA ResHome page
K. Ishida, Y. Niwa, T. Yamashino, and T. Mizuno
A Genome-Wide Compilation of the Two-Component Systems in Lotus japonicus
DNA Res, August 1, 2009; 16(4): 237 - 247.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. Hejatko, H. Ryu, G.-T. Kim, R. Dobesova, S. Choi, S. M. Choi, P. Soucek, J. Horak, B. Pekarova, K. Palme, et al.
The Histidine Kinases CYTOKININ-INDEPENDENT1 and ARABIDOPSIS HISTIDINE KINASE2 and 3 Regulate Vascular Tissue Development in Arabidopsis Shoots
PLANT CELL, July 1, 2009; 21(7): 2008 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
G. A. Ramirez-Carvajal, A. M. Morse, C. Dervinis, and J. M. Davis
The Cytokinin Type-B Response Regulator PtRR13 Is a Negative Regulator of Adventitious Root Development in Populus
Plant Physiology, June 1, 2009; 150(2): 759 - 771.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Zhao, Y. Hu, M. Dai, L. Huang, and D.-X. Zhou
The WUSCHEL-Related Homeobox Gene WOX11 Is Required to Activate Shoot-Borne Crown Root Development in Rice
PLANT CELL, March 1, 2009; 21(3): 736 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
C. Herve, P. Dabos, C. Bardet, A. Jauneau, M. C. Auriac, A. Ramboer, F. Lacout, and D. Tremousaygue
In Vivo Interference with AtTCP20 Function Induces Severe Plant Growth Alterations and Deregulates the Expression of Many Genes Important for Development
Plant Physiology, March 1, 2009; 149(3): 1462 - 1477.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
T. Vernie, S. Moreau, F. de Billy, J. Plet, J.-P. Combier, C. Rogers, G. Oldroyd, F. Frugier, A. Niebel, and P. Gamas
EFD Is an ERF Transcription Factor Involved in the Control of Nodule Number and Differentiation in Medicago truncatula
PLANT CELL, October 1, 2008; 20(10): 2696 - 2713.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
Y. O. Zubo, M. V. Yamburenko, S. Y. Selivankina, F. M. Shakirova, A. M. Avalbaev, N. V. Kudryakova, N. K. Zubkova, K. Liere, O. N. Kulaeva, V. V. Kusnetsov, et al.
Cytokinin Stimulates Chloroplast Transcription in Detached Barley Leaves
Plant Physiology, October 1, 2008; 148(2): 1082 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
R. D. Argyros, D. E. Mathews, Y.-H. Chiang, C. M. Palmer, D. M. Thibault, N. Etheridge, D. A. Argyros, M. G. Mason, J. J. Kieber, and G. E. Schaller
Type B Response Regulators of Arabidopsis Play Key Roles in Cytokinin Signaling and Plant Development
PLANT CELL, August 1, 2008; 20(8): 2102 - 2116.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
A. Pineda Rodo, N. Brugiere, R. Vankova, J. Malbeck, J. M. Olson, S. C. Haines, R. C. Martin, J. E. Habben, D. W. S. Mok, and M. C. Mok
Over-expression of a zeatin O-glucosylation gene in maize leads to growth retardation and tasselseed formation
J. Exp. Bot., July 1, 2008; 59(10): 2673 - 2686.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
A. Heyl, E. Ramireddy, W. G. Brenner, M. Riefler, J. Allemeersch, and T. Schmulling
The Transcriptional Repressor ARR1-SRDX Suppresses Pleiotropic Cytokinin Activities in Arabidopsis
Plant Physiology, July 1, 2008; 147(3): 1380 - 1395.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
A. Kuderova, I. Urbankova, M. Valkova, J. Malbeck, B. Brzobohaty, D. Nemethova, and J. Hejatko
Effects of Conditional IPT-Dependent Cytokinin Overproduction on Root Architecture of Arabidopsis Seedlings
Plant Cell Physiol., April 1, 2008; 49(4): 570 - 582.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
D. J. Wohlbach, B. F. Quirino, and M. R. Sussman
Analysis of the Arabidopsis Histidine Kinase ATHK1 Reveals a Connection between Vegetative Osmotic Stress Sensing and Seed Maturation
PLANT CELL, April 1, 2008; 20(4): 1101 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
F. Chevalier, D. Perazza, F. Laporte, G. Le Henanff, P. Hornitschek, J.-M. Bonneville, M. Herzog, and G. Vachon
GeBP and GeBP-Like Proteins Are Noncanonical Leucine-Zipper Transcription Factors That Regulate Cytokinin Response in Arabidopsis
Plant Physiology, March 1, 2008; 146(3): 1142 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Depuydt, K. Dolezal, M. Van Lijsebettens, T. Moritz, M. Holsters, and D. Vereecke
Modulation of the Hormone Setting by Rhodococcus fascians Results in Ectopic KNOX Activation in Arabidopsis
Plant Physiology, March 1, 2008; 146(3): 1267 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
K. Ishida, T. Yamashino, A. Yokoyama, and T. Mizuno
Three Type-B Response Regulators, ARR1, ARR10 and ARR12, Play Essential but Redundant Roles in Cytokinin Signal Transduction Throughout the Life Cycle of Arabidopsis thaliana
Plant Cell Physiol., January 1, 2008; 49(1): 47 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
S. U. Andersen, S. Buechel, Z. Zhao, K. Ljung, O. Novak, W. Busch, C. Schuster, and J. U. Lohmann
Requirement of B2-Type Cyclin-Dependent Kinases for Meristem Integrity in Arabidopsis thaliana
PLANT CELL, January 1, 2008; 20(1): 88 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. P.C. To, J. Deruere, B. B. Maxwell, V. F. Morris, C. E. Hutchison, F. J. Ferreira, G. E. Schaller, and J. J. Kieber
Cytokinin Regulates Type-A Arabidopsis Response Regulator Activity and Protein Stability via Two-Component Phosphorelay
PLANT CELL, December 1, 2007; 19(12): 3901 - 3914.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
L. Laplaze, E. Benkova, I. Casimiro, L. Maes, S. Vanneste, R. Swarup, D. Weijers, V. Calvo, B. Parizot, M. B. Herrera-Rodriguez, et al.
Cytokinins Act Directly on Lateral Root Founder Cells to Inhibit Root Initiation
PLANT CELL, December 1, 2007; 19(12): 3889 - 3900.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
P. Soucek, P. Klima, A. Rekova, and B. Brzobohaty
Involvement of hormones and KNOXI genes in early Arabidopsis seedling development
J. Exp. Bot., October 20, 2007; (2007) erm236v1.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
B. Muller and J. Sheen
Arabidopsis Cytokinin Signaling Pathway
Sci. Signal., October 9, 2007; 2007(407): cm5 - cm5.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
V. Mira-Rodado, U. Sweere, C. Grefen, T. Kunkel, E. Fejes, F. Nagy, E. Schafer, and K. Harter
Functional cross-talk between two-component and phytochrome B signal transduction in Arabidopsis
J. Exp. Bot., July 1, 2007; 58(10): 2595 - 2607.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
N. Hirose, N. Makita, M. Kojima, T. Kamada-Nobusada, and H. Sakakibara
Overexpression of a Type-A Response Regulator Alters Rice Morphology and Cytokinin Metabolism
Plant Cell Physiol., March 1, 2007; 48(3): 523 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
M. Taniguchi, N. Sasaki, T. Tsuge, T. Aoyama, and A. Oka
ARR1 Directly Activates Cytokinin Response Genes that Encode Proteins with Diverse Regulatory Functions
Plant Cell Physiol., February 1, 2007; 48(2): 263 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
A. Yokoyama, T. Yamashino, Y.-I. Amano, Y. Tajima, A. Imamura, H. Sakakibara, and T. Mizuno
Type-B ARR Transcription Factors, ARR10 and ARR12, are Implicated in Cytokinin-Mediated Regulation of Protoxylem Differentiation in Roots of Arabidopsis thaliana
Plant Cell Physiol., January 1, 2007; 48(1): 84 - 96.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
S. Hanano, M. A. Domagalska, F. Nagy, and S. J. Davis
Multiple phytohormones influence distinct parameters of the plant circadian clock
Genes Cells, December 1, 2006; 11(12): 1381 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
Y. Ikeda, H. Banno, Q.-W. Niu, S. H. Howell, and N.-H. Chua
The ENHANCER OF SHOOT REGENERATION 2 gene in Arabidopsis Regulates CUP-SHAPED COTYLEDON 1 at the Transcriptional Level and Controls Cotyledon Development
Plant Cell Physiol., November 1, 2006; 47(11): 1443 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. E. Hutchison, J. Li, C. Argueso, M. Gonzalez, E. Lee, M. W. Lewis, B. B. Maxwell, T. D. Perdue, G. E. Schaller, J. M. Alonso, et al.
The Arabidopsis Histidine Phosphotransfer Proteins Are Redundant Positive Regulators of Cytokinin Signaling
PLANT CELL, November 1, 2006; 18(11): 3073 - 3087.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
S. Gonzalez-Rizzo, M. Crespi, and F. Frugier
The Medicago truncatula CRE1 Cytokinin Receptor Regulates Lateral Root Development and Early Symbiotic Interaction with Sinorhizobium meliloti
PLANT CELL, October 1, 2006; 18(10): 2680 - 2693.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
T. Sakamoto, H. Sakakibara, M. Kojima, Y. Yamamoto, H. Nagasaki, Y. Inukai, Y. Sato, and M. Matsuoka
Ectopic Expression of KNOTTED1-Like Homeobox Protein Induces Expression of Cytokinin Biosynthesis Genes in Rice
Plant Physiology, September 1, 2006; 142(1): 54 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. M. Rashotte, M. G. Mason, C. E. Hutchison, F. J. Ferreira, G. E. Schaller, and J. J. Kieber
A subset of Arabidopsis AP2 transcription factors mediates cytokinin responses in concert with a two-component pathway
PNAS, July 18, 2006; 103(29): 11081 - 11085.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
P. Che, S. Lall, D. Nettleton, and S. H. Howell
Gene Expression Programs during Shoot, Root, and Callus Development in Arabidopsis Tissue Culture
Plant Physiology, June 1, 2006; 141(2): 620 - 637.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. S. Pischke, E. L. Huttlin, A. D. Hegeman, and M. R. Sussman
A Transcriptome-Based Characterization of Habituation in Plant Tissue Culture
Plant Physiology, April 1, 2006; 140(4): 1255 - 1278.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. J. Kim, H. Ryu, S. H. Hong, H. R. Woo, P. O. Lim, I. C. Lee, J. Sheen, H. G. Nam, and I. Hwang
Cytokinin-mediated control of leaf longevity by AHK3 through phosphorylation of ARR2 in Arabidopsis
PNAS, January 17, 2006; 103(3): 814 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
P. A. Salome, J. P.C. To, J. J. Kieber, and C. R. McClung
Arabidopsis Response Regulators ARR3 and ARR4 Play Cytokinin-Independent Roles in the Control of Circadian Period
PLANT CELL, January 1, 2006; 18(1): 55 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. Riefler, O. Novak, M. Strnad, and T. Schmulling
Arabidopsis Cytokinin Receptor Mutants Reveal Functions in Shoot Growth, Leaf Senescence, Seed Size, Germination, Root Development, and Cytokinin Metabolism
PLANT CELL, January 1, 2006; 18(1): 40 - 54.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
M. G. Mason, D. E. Mathews, D. A. Argyros, B. B. Maxwell, J. J. Kieber, J. M. Alonso, J. R. Ecker, and G. E. Schaller
Multiple Type-B Response Regulators Mediate Cytokinin Signal Transduction in Arabidopsis
PLANT CELL, November 1, 2005; 17(11): 3007 - 3018.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. M. Ellis, P. Nagpal, J. C. Young, G. Hagen, T. J. Guilfoyle, and J. W. Reed
AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
Development, October 15, 2005; 132(20): 4563 - 4574.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Cutler and P. McCourt
Dude, Where's My Phenotype? Dealing with Redundancy in Signaling Networks
Plant Physiology, June 1, 2005; 138(2): 558 - 559.
[Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. M. Franco-Zorrilla, A. C. Martin, A. Leyva, and J. Paz-Ares
Interaction between Phosphate-Starvation, Sugar, and Cytokinin Signaling in Arabidopsis and the Roles of Cytokinin Receptors CRE1/AHK4 and AHK3
Plant Physiology, June 1, 2005; 138(2): 847 - 857.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
T. Kiba, T. Naitou, N. Koizumi, T. Yamashino, H. Sakakibara, and T. Mizuno
Combinatorial Microarray Analysis Revealing Arabidopsis Genes Implicated in Cytokinin Responses through the His->Asp Phosphorelay Circuitry
Plant Cell Physiol., February 1, 2005; 46(2): 339 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Greenboim-Wainberg, I. Maymon, R. Borochov, J. Alvarez, N. Olszewski, N. Ori, Y. Eshed, and D. Weiss
Cross Talk between Gibberellin and Cytokinin: The Arabidopsis GA Response Inhibitor SPINDLY Plays a Positive Role in Cytokinin Signaling
PLANT CELL, January 1, 2005; 17(1): 92 - 102.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
T. Kiba, K. Aoki, H. Sakakibara, and T. Mizuno
Arabidopsis Response Regulator, ARR22, Ectopic Expression of Which Results in Phenotypes Similar to the wol Cytokinin-Receptor Mutant
Plant Cell Physiol., August 15, 2004; 45(8): 1063 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Higuchi, M. S. Pischke, A. P. Mahonen, K. Miyawaki, Y. Hashimoto, M. Seki, M. Kobayashi, K. Shinozaki, T. Kato, S. Tabata, et al.
In planta functions of the Arabidopsis cytokinin receptor family
PNAS, June 8, 2004; 101(23): 8821 - 8826.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2004 by the American Society of Plant Biologists