Plant Cell Hybrigenics The Protein Interactions Experts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online February 18, 2004; 10.1105/tpc.016808

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
16/3/769    most recent
tpc.016808v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Plant Cell
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Somers, D. E.
Right arrow Articles by Geng, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Somers, D. E.
Right arrow Articles by Geng, R.
Agricola
Right arrow Articles by Somers, D. E.
Right arrow Articles by Geng, R.
The Plant Cell 16:769-782 (2004)
© 2004 American Society of Plant Biologists

The F-Box Protein ZEITLUPE Confers Dosage-Dependent Control on the Circadian Clock, Photomorphogenesis, and Flowering Time

David E. Somers1, Woe-Yeon Kim and Ruishuang Geng

Department of Plant Biology/Plant Biotechnology Center, Ohio State University, Columbus, Ohio 43210

1 To whom correspondence should be addressed. E-mail somers.24{at}osu.edu; fax 614-292-5379

As an F-box protein, ZEITLUPE (ZTL) is involved in targeting one or more substrates for ubiquitination and degradation via the proteasome. The initial characterization of ZTL suggested a function limited largely to the regulation of the circadian clock. Here, we show a considerably broader role for ZTL in the control of circadian period and photomorphogenesis. Using a ZTL-specific antibody, we quantitated and characterized a ZTL dosage series that ranges from a null mutation to a strong ZTL overexpressor. In the dark, ztl null mutations lengthen circadian period, and overexpression causes arrhythmicity, suggesting a more comprehensive role for this protein in the clock than previously suspected. In the light, circadian period becomes increasingly shorter at higher levels of ZTL, to the point of arrhythmicity. By contrast, hypocotyl length increases and flowering time is delayed in direct proportion to the level of ZTL. We propose a novel testable mechanism by which circadian period and amplitude may act together to gate phytochrome B–mediated suppression of hypocotyl. We also demonstrate that ZTL-dependent delay of flowering is mediated through decreases in CONSTANS and FLOWERING LOCUS T message levels, thus directly linking proteasome-dependent proteolysis to flowering.


Related articles in Plant Cell:

F-Box Proteins Take Center Stage
Nancy A. Eckardt
Plant Cell 2004 16: 558-561. [Full Text]  



This article has been cited by other articles:


Home page
 Plant Physiol.Home page
E. Yakir, D. Hilman, I. Kron, M. Hassidim, N. Melamed-Book, and R. M. Green
Posttranslational Regulation of CIRCADIAN CLOCK ASSOCIATED1 in the Circadian Oscillator of Arabidopsis
Plant Physiology, June 1, 2009; 150(2): 844 - 857.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Fujiwara, L. Wang, L. Han, S.-S. Suh, P. A. Salome, C. R. McClung, and D. E. Somers
Post-translational Regulation of the Arabidopsis Circadian Clock through Selective Proteolysis and Phosphorylation of Pseudo-response Regulator Proteins
J. Biol. Chem., August 22, 2008; 283(34): 23073 - 23083.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
P. A. Salome, Q. Xie, and C. R. McClung
Circadian Timekeeping during Early Arabidopsis Development
Plant Physiology, July 1, 2008; 147(3): 1110 - 1125.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
E. L. Martin-Tryon and S. L. Harmer
XAP5 CIRCADIAN TIMEKEEPER Coordinates Light Signals for Proper Timing of Photomorphogenesis and the Circadian Clock in Arabidopsis
PLANT CELL, May 1, 2008; 20(5): 1244 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. Kim, Y. Kim, M. Yeom, J.-H. Kim, and H. G. Nam
FIONA1 Is Essential for Regulating Period Length in the Arabidopsis Circadian Clock
PLANT CELL, February 1, 2008; 20(2): 307 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
H. Shen, P. Luong, and E. Huq
The F-Box Protein MAX2 Functions as a Positive Regulator of Photomorphogenesis in Arabidopsis
Plant Physiology, December 1, 2007; 145(4): 1471 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
S. Ito, N. Nakamichi, T. Kiba, T. Yamashino, and T. Mizuno
Rhythmic and Light-Inducible Appearance of Clock-Associated Pseudo-Response Regulator Protein PRR9 Through Programmed Degradation in the Dark in Arabidopsis thaliana
Plant Cell Physiol., November 1, 2007; 48(11): 1644 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
A. Para, E. M. Farre, T. Imaizumi, J. L. Pruneda-Paz, F. G. Harmon, and S. A. Kay
PRR3 Is a Vascular Regulator of TOC1 Stability in the Arabidopsis Circadian Clock
PLANT CELL, November 1, 2007; 19(11): 3462 - 3473.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
T. Kiba, R. Henriques, H. Sakakibara, and N.-H. Chua
Targeted Degradation of PSEUDO-RESPONSE REGULATOR5 by an SCFZTL Complex Regulates Clock Function and Photomorphogenesis in Arabidopsis thaliana
PLANT CELL, August 1, 2007; 19(8): 2516 - 2530.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
S. Ito, N. Nakamichi, Y. Nakamura, Y. Niwa, T. Kato, M. Murakami, M. Kita, T. Mizoguchi, K. Niinuma, T. Yamashino, et al.
Genetic Linkages Between Circadian Clock-Associated Components and Phytochrome-Dependent Red Light Signal Transduction in Arabidopsis thaliana
Plant Cell Physiol., July 1, 2007; 48(7): 971 - 983.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
Y. Niwa, S. Ito, N. Nakamichi, T. Mizoguchi, K. Niinuma, T. Yamashino, and T. Mizuno
Genetic Linkages of the Circadian Clock-Associated Genes, TOC1, CCA1 and LHY, in the Photoperiodic Control of Flowering Time in Arabidopsis thaliana
Plant Cell Physiol., July 1, 2007; 48(7): 925 - 937.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
K. A. Oliverio, M. Crepy, E. L. Martin-Tryon, R. Milich, S. L. Harmer, J. Putterill, M. J. Yanovsky, and J. J. Casal
GIGANTEA Regulates Phytochrome A-Mediated Photomorphogenesis Independently of Its Role in the Circadian Clock
Plant Physiology, May 1, 2007; 144(1): 495 - 502.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. Jain, A. Nijhawan, R. Arora, P. Agarwal, S. Ray, P. Sharma, S. Kapoor, A. K. Tyagi, and J. P. Khurana
F-Box Proteins in Rice. Genome-Wide Analysis, Classification, Temporal and Spatial Gene Expression during Panicle and Seed Development, and Regulation by Light and Abiotic Stress
Plant Physiology, April 1, 2007; 143(4): 1467 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
D. E. Somers, S. Fujiwara, W.-Y. Kim, and S.-S. Suh
Posttranslational Photomodulation of Circadian Amplitude
Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 193 - 200.
[Abstract] [PDF]

Home page
 Plant Cell PhysiolHome page
M. Murakami, Y. Tago, T. Yamashino, and T. Mizuno
Comparative Overviews of Clock-Associated Genes of Arabidopsis thaliana and Oryza sativa
Plant Cell Physiol., January 1, 2007; 48(1): 110 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
E. L. Martin-Tryon, J. A. Kreps, and S. L. Harmer
GIGANTEA Acts in Blue Light Signaling and Has Biochemically Separable Roles in Circadian Clock and Flowering Time Regulation
Plant Physiology, January 1, 2007; 143(1): 473 - 486.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
L. Gutierrez, G. Conejero, M. Castelain, S. Guenin, J.-L. Verdeil, B. Thomasset, and O. Van Wuytswinkel
Identification of new gene expression regulators specifically expressed during plant seed maturation
J. Exp. Bot., June 1, 2006; 57(9): 1919 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. R. McClung
Plant circadian rhythms.
PLANT CELL, April 1, 2006; 18(4): 792 - 803.
[Full Text] [PDF]

Home page
 Plant Physiol.Home page
E. Kevei, P. Gyula, A. Hall, L. Kozma-Bognar, W.-Y. Kim, M. E. Eriksson, R. Toth, S. Hanano, B. Feher, M. M. Southern, et al.
Forward Genetic Analysis of the Circadian Clock Separates the Multiple Functions of ZEITLUPE
Plant Physiology, March 1, 2006; 140(3): 933 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
P. A. Salome, J. P.C. To, J. J. Kieber, and C. R. McClung
Arabidopsis Response Regulators ARR3 and ARR4 Play Cytokinin-Independent Roles in the Control of Circadian Period
PLANT CELL, January 1, 2006; 18(1): 55 - 69.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
W.-Y. Kim, K. A. Hicks, and D. E. Somers
Independent Roles for EARLY FLOWERING 3 and ZEITLUPE in the Control of Circadian Timing, Hypocotyl Length, and Flowering Time
Plant Physiology, November 1, 2005; 139(3): 1557 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
Y. Fukamatsu, S. Mitsui, M. Yasuhara, Y. Tokioka, N. Ihara, S. Fujita, and T. Kiyosue
Identification of LOV KELCH PROTEIN2 (LKP2)-interacting Factors That Can Recruit LKP2 to Nuclear Bodies
Plant Cell Physiol., August 1, 2005; 46(8): 1340 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. N. Dodd, N. Salathia, A. Hall, E. Kevei, R. Toth, F. Nagy, J. M. Hibberd, A. J. Millar, and A. A. R. Webb
Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage
Science, July 22, 2005; 309(5734): 630 - 633.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. P. Hazen, T. F. Schultz, J. L. Pruneda-Paz, J. O. Borevitz, J. R. Ecker, and S. A. Kay
LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms
PNAS, July 19, 2005; 102(29): 10387 - 10392.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
T. Mizuno and N. Nakamichi
Pseudo-Response Regulators (PRRs) or True Oscillator Components (TOCs)
Plant Cell Physiol., May 1, 2005; 46(5): 677 - 685.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
N. Nakamichi, M. Kita, S. Ito, T. Yamashino, and T. Mizuno
PSEUDO-RESPONSE REGULATORS, PRR9, PRR7 and PRR5, Together Play Essential Roles Close to the Circadian Clock of Arabidopsis thaliana
Plant Cell Physiol., May 1, 2005; 46(5): 686 - 698.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
N. Nakamichi, M. Kita, S. Ito, E. Sato, T. Yamashino, and T. Mizuno
The Arabidopsis Pseudo-response Regulators, PRR5 and PRR7, Coordinately Play Essential Roles for Circadian Clock Function
Plant Cell Physiol., April 1, 2005; 46(4): 609 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. Moon, G. Parry, and M. Estelle
The Ubiquitin-Proteasome Pathway and Plant Development
PLANT CELL, December 1, 2004; 16(12): 3181 - 3195.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Monte, J. M. Tepperman, B. Al-Sady, K. A. Kaczorowski, J. M. Alonso, J. R. Ecker, X. Li, Y. Zhang, and P. H. Quail
Inaugural Article: The phytochrome-interacting transcription factor, PIF3, acts early, selectively, and positively in light-induced chloroplast development
PNAS, November 16, 2004; 101(46): 16091 - 16098.
[Abstract] [Full Text] [PDF]

Home page
 J Biol RhythmsHome page
P. A. Salome and C. R. McClung
The Arabidopsis thaliana Clock
J Biol Rhythms, October 1, 2004; 19(5): 425 - 435.
[Abstract] [PDF]

Home page
 Plant CellHome page
N. A. Eckardt
F-Box Proteins Take Center Stage
PLANT CELL, March 1, 2004; 16(3): 558 - 561.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2004 by the American Society of Plant Biologists