Plant Cell Hybrigenics The Protein Interactions Experts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online May 21, 2004; 10.1105/tpc.021378

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
16/6/1633    most recent
tpc.021378v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (37)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Molinier, J.
Right arrow Articles by Hohn, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Molinier, J.
Right arrow Articles by Hohn, B.
Agricola
Right arrow Articles by Molinier, J.
Right arrow Articles by Hohn, B.
The Plant Cell 16:1633-1643 (2004)
© 2004 American Society of Plant Biologists

CENTRIN2 Modulates Homologous Recombination and Nucleotide Excision Repair in Arabidopsis

Jean Molinier1, Cynthia Ramos2, Olivier Fritsch and Barbara Hohn

Friedrich Miescher-Institute for Biomedical Research, CH-4058 Basel, Switzerland

1 To whom correspondence should be addressed. E-mail jean.molinier{at}fmi.ch; fax 41 61 697 39 76.

A genetic screen of a population of Arabidopsis thaliana lines exhibiting enhanced somatic homologous recombination yielded a mutant affected in expression of a gene encoding a caltractin-like protein (centrin). The hyperrecombinogenic phenotype could be reproduced using RNA interference (RNAi) technology. Both the original mutant and the RNAi plants exhibited a moderate UV-C sensitivity as well as a reduced efficiency of in vitro repair of UV-damaged DNA. Transcription profiling of the mutant showed that expression of components of the nucleotide excision repair (NER) pathway and of factors involved in other DNA repair processes were significantly changed. Our data suggest an indirect involvement of centrin in recombinational DNA repair via the modulation of the NER pathway. These findings thus point to a novel interconnection between an early step of NER and homologous recombination, which may play a critical role in plant DNA repair.




This article has been cited by other articles:


Home page
 Plant CellHome page
D. Schuermann, O. Fritsch, J. M. Lucht, and B. Hohn
Replication Stress Leads to Genome Instabilities in Arabidopsis DNA Polymerase {delta} Mutants
PLANT CELL, September 1, 2009; 21(9): 2700 - 2714.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Yin, X. Zhang, J. Liu, Y. Wang, J. He, T. Yang, X. Hong, Q. Yang, and Z. Gong
Epigenetic Regulation, Somatic Homologous Recombination, and Abscisic Acid Signaling Are Influenced by DNA Polymerase {epsilon} Mutation in Arabidopsis
PLANT CELL, February 1, 2009; 21(2): 386 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. Azimzadeh, P. Nacry, A. Christodoulidou, S. Drevensek, C. Camilleri, N. Amiour, F. Parcy, M. Pastuglia, and D. Bouchez
Arabidopsis TONNEAU1 Proteins Are Essential for Preprophase Band Formation and Interact with Centrin
PLANT CELL, August 1, 2008; 20(8): 2146 - 2159.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. K. Resendes, B. A. Rasala, and D. J. Forbes
Centrin 2 Localizes to the Vertebrate Nuclear Pore and Plays a Role in mRNA and Protein Export
Mol. Cell. Biol., March 1, 2008; 28(5): 1755 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Selvapandiyan, P. Kumar, J. C. Morris, J. L. Salisbury, C. C. Wang, and H. L. Nakhasi
Centrin1 Is Required for Organelle Segregation and Cytokinesis in Trypanosoma brucei
Mol. Biol. Cell, September 1, 2007; 18(9): 3290 - 3301.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Despras, P. Pfeiffer, B. Salles, P. Calsou, S. Kuhfittig-Kulle, J. F. Angulo, and D. S.F. Biard
Long-term XPC Silencing Reduces DNA Double-Strand Break Repair
Cancer Res., March 15, 2007; 67(6): 2526 - 2534.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
K. Nagamune and L. D. Sibley
Comparative Genomic and Phylogenetic Analyses of Calcium ATPases and Calcium-Regulated Proteins in the Apicomplexa
Mol. Biol. Evol., August 1, 2006; 23(8): 1613 - 1627.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. H. Sheehan, C. G. Bunick, H. Hu, P. A. Fagan, S. M. Meyn, and W. J. Chazin
Structure of the N-terminal Calcium Sensor Domain of Centrin Reveals the Biochemical Basis for Domain-specific Function
J. Biol. Chem., February 3, 2006; 281(5): 2876 - 2881.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Shaked, C. Melamed-Bessudo, and A. A. Levy
High-frequency gene targeting in Arabidopsis plants expressing the yeast RAD54 gene
PNAS, August 23, 2005; 102(34): 12265 - 12269.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
R. Nishi, Y. Okuda, E. Watanabe, T. Mori, S. Iwai, C. Masutani, K. Sugasawa, and F. Hanaoka
Centrin 2 Stimulates Nucleotide Excision Repair by Interacting with Xeroderma Pigmentosum Group C Protein
Mol. Cell. Biol., July 1, 2005; 25(13): 5664 - 5674.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
S. Geimer and M. Melkonian
Centrin Scaffold in Chlamydomonas reinhardtii Revealed by Immunoelectron Microscopy
Eukaryot. Cell, July 1, 2005; 4(7): 1253 - 1263.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2004 by the American Society of Plant Biologists