Plant Cell Huazhong Agricultural University
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online June 18, 2004; 10.1105/tpc.021949

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
16/7/1870    most recent
tpc.021949v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (33)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feng, S.
Right arrow Articles by Deng, X. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feng, S.
Right arrow Articles by Deng, X. W.
Agricola
Right arrow Articles by Feng, S.
Right arrow Articles by Deng, X. W.
The Plant Cell 16:1870-1882 (2004)
© 2004 American Society of Plant Biologists

Arabidopsis CAND1, an Unmodified CUL1-Interacting Protein, Is Involved in Multiple Developmental Pathways Controlled by Ubiquitin/Proteasome-Mediated Protein Degradation

Suhua Fenga, Yunping Shena,b, James A. Sullivana, Vicente Rubioa, Yue Xiongc, Tai-ping Sund and Xing Wang Denga,b,1

a Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520-8104
b Peking-Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology, College of Life Sciences, Peking University, Beijing 100871, China
c Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599
d Department of Biology, Duke University, Durham, North Carolina 27708-1000

1 To whom correspondence should be addressed. E-mail xingwang.deng{at}yale.edu; fax 203-432-5726.

Ubiquitin/proteasome-mediated protein degradation controls various developmental pathways in eukaryotes. Cullin-containing complexes are both versatile and abundant groups of RING family ubiquitin E3 ligases, whose activities are subject to control by RUB/Nedd8 (for related to ubiquitin/neural precursor cell-expressed developmentally downregulated 8) modification of their cullin subunits. Here, we report the identification of an Arabidopsis thaliana counterpart of human CAND1 (cullin-associated and neddylation-dissociated) and demonstrate that it can preferentially interact with unmodified CUL1. The Arabidopsis cand1-1 null mutant displays distinct phenotypes, including late flowering, aerial rosettes, floral organ defects, low fertility, dwarfism, loss of apical dominance, and altered responses to multiple plant hormones. Molecular analyses show that many of these defects are because of compromised activity of CUL1-containing ubiquitin E3 ligases, indicating that CAND1 is required for their optimal activity. Furthermore, the cand1-1 mutant displays a partial constitutive photomorphogenic phenotype and has defects in HY5 degradation in the absence of light, a process mediated by a different RING family E3, COP1. Thus, our data provides genetic support for a critical role of CAND1 in regulating various ubiquitin E3 ligases and their targeted cellular and developmental pathways.




This article has been cited by other articles:


Home page
 Mol PlantHome page
H. Zhu, G.-J. Li, L. Ding, X. Cui, H. Berg, S. M. Assmann, and Y. Xia
Arabidopsis Extra Large G-Protein 2 (XLG2) Interacts with the G{beta} Subunit of Heterotrimeric G Protein and Functions in Disease Resistance
Mol Plant, May 1, 2009; 2(3): 513 - 525.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. Gilkerson, J. Hu, J. Brown, A. Jones, T.-p. Sun, and J. Callis
Isolation and Characterization of cul1-7, a Recessive Allele of CULLIN1 That Disrupts SCF Function at the C Terminus of CUL1 in Arabidopsis thaliana
Genetics, March 1, 2009; 181(3): 945 - 963.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Shen, Z. Zhou, S. Feng, J. Li, A. Tan-Wilson, L.-J. Qu, H. Wang, and X. W. Deng
Phytochrome A Mediates Rapid Red Light-Induced Phosphorylation of Arabidopsis FAR-RED ELONGATED HYPOCOTYL1 in a Low Fluence Response
PLANT CELL, February 1, 2009; 21(2): 494 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Sonnberg, B. T. Seet, T. Pawson, S. B. Fleming, and A. A. Mercer
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes
PNAS, August 5, 2008; 105(31): 10955 - 10960.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
M. Christian, W. B. Hannah, H. Luthen, and A. M. Jones
Identification of auxins by a chemical genomics approach
J. Exp. Bot., July 1, 2008; 59(10): 2757 - 2767.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Zhang, H. Ito, M. Quint, H. Huang, L. D. Noel, and W. M. Gray
Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex
PNAS, June 17, 2008; 105(24): 8470 - 8475.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Zhang, S. Feng, F. Chen, H. Chen, J. Wang, C. McCall, Y. Xiong, and X. W. Deng
Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 Forms a Nuclear E3 Ubiquitin Ligase with DDB1 and CUL4 That Is Involved in Multiple Plant Developmental Processes
PLANT CELL, June 1, 2008; 20(6): 1437 - 1455.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
A. W. Woodward, S. E. Ratzel, E. E. Woodward, Y. Shamoo, and B. Bartel
Mutation of E1-CONJUGATING ENZYME-RELATED1 Decreases RELATED TO UBIQUITIN Conjugation and Alters Auxin Response and Development
Plant Physiology, June 1, 2007; 144(2): 976 - 987.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
K. Dreher and J. Callis
Ubiquitin, Hormones and Biotic Stress in Plants
Ann. Bot., May 1, 2007; 99(5): 787 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. Moon, Y. Zhao, X. Dai, W. Zhang, W. M. Gray, E. Huq, and M. Estelle
A New CULLIN 1 Mutant Has Altered Responses to Hormones and Light in Arabidopsis
Plant Physiology, February 1, 2007; 143(2): 684 - 696.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. M. Alonso-Peral, H. Candela, J. C. del Pozo, A. Martinez-Laborda, M. R. Ponce, and J. L. Micol
The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis
Development, October 1, 2006; 133(19): 3755 - 3766.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Chen, Y. Shen, X. Tang, L. Yu, J. Wang, L. Guo, Y. Zhang, H. Zhang, S. Feng, E. Strickland, et al.
Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development
PLANT CELL, August 1, 2006; 18(8): 1991 - 2004.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
Q. He, P. Cheng, Q. He, and Y. Liu
The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex
Genes & Dev., July 1, 2005; 19(13): 1518 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
A. W. WOODWARD and B. BARTEL
Auxin: Regulation, Action, and Interaction
Ann. Bot., April 1, 2005; 95(5): 707 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. Moon, G. Parry, and M. Estelle
The Ubiquitin-Proteasome Pathway and Plant Development
PLANT CELL, December 1, 2004; 16(12): 3181 - 3195.
[Full Text] [PDF]

Home page
 Plant CellHome page
H.-w. Chuang, W. Zhang, and W. M. Gray
Arabidopsis ETA2, an Apparent Ortholog of the Human Cullin-Interacting Protein CAND1, Is Required for Auxin Responses Mediated by the SCFTIR1 Ubiquitin Ligase
PLANT CELL, July 1, 2004; 16(7): 1883 - 1897.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2004 by the American Society of Plant Biologists