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First published online November 10, 2006; 10.1105/tpc.106.045617

The Plant Cell 18:2929-2945 (2006)
© 2006 American Society of Plant Biologists

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The Balance between the MIR164A and CUC2 Genes Controls Leaf Margin Serration in Arabidopsis[W]

Krisztina Nikovicsa, Thomas Bleina, Alexis Peaucellea, Tetsuya Ishidab,1, Halima Morina, Mitsuhiro Aidab and Patrick Laufsa,2

a Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
b Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan

2 To whom correspondence should be addressed. E-mail laufs{at}versailles.inra.fr; fax 33-130-83-3099.

CUP-SHAPED COTYLEDON1 (CUC1), CUC2, and CUC3 define the boundary domain around organs in the Arabidopsis thaliana meristem. CUC1 and CUC2 transcripts are targeted by a microRNA (miRNA), miR164, encoded by MIR164A, B, and C. We show that each MIR164 is transcribed to generate a large population of primary miRNAs of variable size with a locally conserved secondary structure around the pre-miRNA. We identified mutations in the MIR164A gene that deepen serration of the leaf margin. By contrast, leaves of plants overexpressing miR164 have smooth margins. Enhanced leaf serration was observed following the expression of an miR164-resistant CUC2 but not of an miR164-resistant CUC1. Furthermore, CUC2 inactivation abolished serration in mir164a mutants and the wild type, whereas CUC1 inactivation did not. Thus, CUC2 specifically controls leaf margin development. CUC2 and MIR164A are transcribed in overlapping domains at the margins of young leaf primordia, with transcription gradually restricted to the sinus, where the leaf margins become serrated. We suggest that leaf margin development is controlled by a two-step process in Arabidopsis. The pattern of serration is determined first, independently of CUC2 and miR164. The balance between coexpressed CUC2 and MIR164A then determines the extent of serration.




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