Plant Cell Huazhong Agricultural University
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online July 14, 2006; 10.1105/tpc.106.043224

The Plant Cell 18:1991-2004 (2006)
© 2006 American Society of Plant Biologists

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
18/8/1991    most recent
tpc.106.043224v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, H.
Right arrow Articles by Deng, X. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, H.
Right arrow Articles by Deng, X. W.
Agricola
Right arrow Articles by Chen, H.
Right arrow Articles by Deng, X. W.

Arabidopsis CULLIN4 Forms an E3 Ubiquitin Ligase with RBX1 and the CDD Complex in Mediating Light Control of Development

Haodong Chena,b, Yunping Shena,c, Xiaobo Tangd, Lu Yub, Jia Wangb, Lan Guoa,b, Yu Zhanga,b, Huiyong Zhangb, Suhua Fengb,c, Elizabeth Stricklandc, Ning Zhengd and Xing Wang Denga,b,c,1

a Peking–Yale Joint Center of Plant Molecular Genetics and Agrobiotechnology, College of Life Sciences, Peking University, Beijing 100871, China
b National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China
c Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520-8104
d Department of Pharmacology, University of Washington, Seattle, Washington 98195

1 To whom correspondence should be addressed. E-mail xingwang.deng{at}yale.edu; fax 203-432-5726.

Repression of photomorphogenesis in Arabidopsis thaliana requires activity of the COP9 signalosome (CSN), CDD, and COP1 complexes, but how these three complexes work in concert to accomplish this important developmental switch has remained unknown. Here, we demonstrate that Arabidopsis CULLIN4 (CUL4) associates with the CDD complex and a common catalytic subunit to form an active E3 ubiquitin ligase both in vivo and in vitro. The partial loss of function of CUL4 resulted in a constitutive photomorphogenic phenotype with respect to morphogenesis and light-regulated gene expression. Furthermore, CUL4 exhibits a synergistic genetic interaction with COP10 and DET1. Therefore, this CUL4-based E3 ligase is essential for the repression of photomorphogenesis. This CUL4-based E3 ligase appears to associate physically with COP1 E3 ligase and positively regulates the COP1-dependent degradation of photomorphogenesis-promoting transcription factors, whereas the CSN controls the biochemical modification of CUL4 essential for E3 activity. Thus, this study suggests a biochemical activity connection between CSN and CDD complexes in their cooperation with COP1 in orchestrating the repression of photomorphogenesis.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J. Stuttmann, E. Lechner, R. Guerois, J. E. Parker, L. Nussaume, P. Genschik, and L. D. Noel
COP9 Signalosome- and 26S Proteasome-dependent Regulation of SCFTIR1 Accumulation in Arabidopsis
J. Biol. Chem., March 20, 2009; 284(12): 7920 - 7930.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
E. A. Ananieva, G. E. Gillaspy, A. Ely, R. N. Burnette, and F. L. Erickson
Interaction of the WD40 Domain of a Myoinositol Polyphosphate 5-Phosphatase with SnRK1 Links Inositol, Sugar, and Stress Signaling
Plant Physiology, December 1, 2008; 148(4): 1868 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
D. Zhu, A. Maier, J.-H. Lee, S. Laubinger, Y. Saijo, H. Wang, L.-J. Qu, U. Hoecker, and X. W. Deng
Biochemical Characterization of Arabidopsis Complexes Containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA Proteins in Light Control of Plant Development
PLANT CELL, September 1, 2008; 20(9): 2307 - 2323.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
T. Ariizumi, K. Murase, T.-p. Sun, and C. M. Steber
Proteolysis-Independent Downregulation of DELLA Repression in Arabidopsis by the Gibberellin Receptor GIBBERELLIN INSENSITIVE DWARF1
PLANT CELL, September 1, 2008; 20(9): 2447 - 2459.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Zhang, H. Ito, M. Quint, H. Huang, L. D. Noel, and W. M. Gray
Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex
PNAS, June 17, 2008; 105(24): 8470 - 8475.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. M. N. Dohmann, M. P. Levesque, L. De Veylder, I. Reichardt, G. Jurgens, M. Schmid, and C. Schwechheimer
The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability
Development, June 1, 2008; 135(11): 2013 - 2022.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
Y. Zhang, S. Feng, F. Chen, H. Chen, J. Wang, C. McCall, Y. Xiong, and X. W. Deng
Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 Forms a Nuclear E3 Ubiquitin Ligase with DDB1 and CUL4 That Is Involved in Multiple Plant Developmental Processes
PLANT CELL, June 1, 2008; 20(6): 1437 - 1455.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J.-H. Lee, W. Terzaghi, G. Gusmaroli, J.-B. F. Charron, H.-J. Yoon, H. Chen, Y. J. He, Y. Xiong, and X. W. Deng
Characterization of Arabidopsis and Rice DWD Proteins and Their Roles as Substrate Receptors for CUL4-RING E3 Ubiquitin Ligases
PLANT CELL, January 1, 2008; 20(1): 152 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
H. Shen, P. Luong, and E. Huq
The F-Box Protein MAX2 Functions as a Positive Regulator of Photomorphogenesis in Arabidopsis
Plant Physiology, December 1, 2007; 145(4): 1471 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. Pick, O.-S. Lau, T. Tsuge, S. Menon, Y. Tong, N. Dohmae, S. M. Plafker, X. W. Deng, and N. Wei
Mammalian DET1 Regulates Cul4A Activity and Forms Stable Complexes with E2 Ubiquitin-Conjugating Enzymes
Mol. Cell. Biol., July 1, 2007; 27(13): 4708 - 4719.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
K. Dreher and J. Callis
Ubiquitin, Hormones and Biotic Stress in Plants
Ann. Bot., May 1, 2007; 99(5): 787 - 822.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
W. M. Al Khateeb and D. F. Schroeder
DDB2, DDB1A and DET1 Exhibit Complex Interactions During Arabidopsis Development
Genetics, May 1, 2007; 176(1): 231 - 242.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
G. Gusmaroli, P. Figueroa, G. Serino, and X. W. Deng
Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction with Arabidopsis Cullin3-Based E3 Ligases
PLANT CELL, February 1, 2007; 19(2): 564 - 581.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Chen, V. J. Karplus, H. Ma, and X. W. Deng
Plant Biology Research Comes of Age in China
PLANT CELL, November 1, 2006; 18(11): 2855 - 2864.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2006 by the American Society of Plant Biologists