Plant Cell Illumina
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

First published online July 21, 2006; 10.1105/tpc.106.041673

The Plant Cell 18:2051-2065 (2006)
© 2006 American Society of Plant Biologists

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow PPT slides of all figures
Right arrow Supplemental Data
Right arrow A correction has been published
Right arrow All Versions of this Article:
18/8/2051    most recent
tpc.106.041673v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (89)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sunkar, R.
Right arrow Articles by Zhu, J.-K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sunkar, R.
Right arrow Articles by Zhu, J.-K.
Agricola
Right arrow Articles by Sunkar, R.
Right arrow Articles by Zhu, J.-K.

Posttranscriptional Induction of Two Cu/Zn Superoxide Dismutase Genes in Arabidopsis Is Mediated by Downregulation of miR398 and Important for Oxidative Stress Tolerance[W]

Ramanjulu Sunkar, Avnish Kapoor and Jian-Kang Zhu1

Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521

1 To whom correspondence should be addressed. E-mail jian-kang.zhu{at}ucr.edu; fax 909-827-7115.

MicroRNAs (miRNAs) are a class of regulatory RNAs of ~21 nucleotides that posttranscriptionally regulate gene expression by directing mRNA cleavage or translational inhibition. Increasing evidence points to a potential role of miRNAs in diverse physiological processes. miR398 targets two closely related Cu/Zn superoxide dismutases (cytosolic CSD1 and chloroplastic CSD2) that can detoxify superoxide radicals. CSD1 and CSD2 transcripts are induced in response to oxidative stress, but the regulatory mechanism of the induction is unknown. Here, we show that miR398 expression is downregulated transcriptionally by oxidative stresses, and this downregulation is important for posttranscriptional CSD1 and CSD2 mRNA accumulation and oxidative stress tolerance. We also provide evidence for an important role of miR398 in specifying the spatial and temporal expression patterns of CSD1 and CSD2 mRNAs. Our results suggest that CSD1 and CSD2 expression is fine-tuned by miR398-directed mRNA cleavage. Additionally, we show that transgenic Arabidopsis thaliana plants overexpressing a miR398-resistant form of CSD2 accumulate more CSD2 mRNA than plants overexpressing a regular CSD2 and are consequently much more tolerant to high light, heavy metals, and other oxidative stresses. Thus, relieving miR398-guided suppression of CSD2 in transgenic plants is an effective new approach to improving plant productivity under oxidative stress conditions.




This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
H. Lee, S. J. Yoo, J. H. Lee, W. Kim, S. K. Yoo, H. Fitzgerald, J. C. Carrington, and J. H. Ahn
Genetic framework for flowering-time regulation by ambient temperature-responsive miRNAs in Arabidopsis
Nucleic Acids Res., January 27, 2010; (2010): gkp1240v1 - gkp1240.
[Abstract] [Full Text] [PDF]

Home page
 Mol PlantHome page
E. Baena-Gonzalez
Energy Signaling in the Regulation of Gene Expression during Stress
Mol Plant, January 15, 2010; (2010) ssp113v1.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
D. Moldovan, A. Spriggs, J. Yang, B. J. Pogson, E. S. Dennis, and I. W. Wilson
Hypoxia-responsive microRNAs and trans-acting small interfering RNAs in Arabidopsis
J. Exp. Bot., January 1, 2010; 61(1): 165 - 177.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
L.-C. Hsieh, S.-I. Lin, A. C.-C. Shih, J.-W. Chen, W.-Y. Lin, C.-Y. Tseng, W.-H. Li, and T.-J. Chiou
Uncovering Small RNA-Mediated Responses to Phosphate Deficiency in Arabidopsis by Deep Sequencing
Plant Physiology, December 1, 2009; 151(4): 2120 - 2132.
[Abstract] [Full Text] [PDF]

Home page
 Mol PlantHome page
C. M. Cohu, S. E. Abdel-Ghany, K. A. Gogolin Reynolds, A. M. Onofrio, J. R. Bodecker, J. A. Kimbrel, K. K. Niyogi, and M. Pilon
Copper Delivery by the Copper Chaperone for Chloroplast and Cytosolic Copper/Zinc-Superoxide Dismutases: Regulation and Unexpected Phenotypes in an Arabidopsis Mutant
Mol Plant, November 1, 2009; 2(6): 1336 - 1350.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
L. Wu, Q. Zhang, H. Zhou, F. Ni, X. Wu, and Y. Qi
Rice MicroRNA Effector Complexes and Targets
PLANT CELL, November 1, 2009; 21(11): 3421 - 3435.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
Y. J. Im, M. Ji, A. Lee, R. Killens, A. M. Grunden, and W. F. Boss
Expression of Pyrococcus furiosus Superoxide Reductase in Arabidopsis Enhances Heat Tolerance
Plant Physiology, October 1, 2009; 151(2): 893 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. Lelandais-Briere, L. Naya, E. Sallet, F. Calenge, F. Frugier, C. Hartmann, J. Gouzy, and M. Crespi
Genome-Wide Medicago truncatula Small RNA Analysis Revealed Novel MicroRNAs and Isoforms Differentially Regulated in Roots and Nodules
PLANT CELL, September 1, 2009; 21(9): 2780 - 2796.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L. Alves-Junior, S. Niemeier, A. Hauenschild, M. Rehmsmeier, and T. Merkle
Comprehensive prediction of novel microRNA targets in Arabidopsis thaliana
Nucleic Acids Res., July 1, 2009; 37(12): 4010 - 4021.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
B. D. Pant, M. Musialak-Lange, P. Nuc, P. May, A. Buhtz, J. Kehr, D. Walther, and W.-R. Scheible
Identification of Nutrient-Responsive Arabidopsis and Rapeseed MicroRNAs by Comprehensive Real-Time Polymerase Chain Reaction Profiling and Small RNA Sequencing
Plant Physiology, July 1, 2009; 150(3): 1541 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
E. Lanet, E. Delannoy, R. Sormani, M. Floris, P. Brodersen, P. Crete, O. Voinnet, and C. Robaglia
Biochemical Evidence for Translational Repression by Arabidopsis MicroRNAs
PLANT CELL, June 1, 2009; 21(6): 1762 - 1768.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. Rodriguez-Serrano, M. C. Romero-Puertas, D. M. Pazmino, P. S. Testillano, M. C. Risueno, L. A. del Rio, and L. M. Sandalio
Cellular Response of Pea Plants to Cadmium Toxicity: Cross Talk between Reactive Oxygen Species, Nitric Oxide, and Calcium
Plant Physiology, May 1, 2009; 150(1): 229 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
L.-J. Xue, J.-J. Zhang, and H.-W. Xue
Characterization and expression profiles of miRNAs in rice seeds
Nucleic Acids Res., February 1, 2009; 37(3): 916 - 930.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
H. Yamasaki, M. Hayashi, M. Fukazawa, Y. Kobayashi, and T. Shikanai
SQUAMOSA Promoter Binding Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis
PLANT CELL, January 1, 2009; 21(1): 347 - 361.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
Z. Zhang, L. Wei, X. Zou, Y. Tao, Z. Liu, and Y. Zheng
Submergence-responsive MicroRNAs are Potentially Involved in the Regulation of Morphological and Metabolic Adaptations in Maize Root Cells
Ann. Bot., October 1, 2008; 102(4): 509 - 519.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
W.-X. Li, Y. Oono, J. Zhu, X.-J. He, J.-M. Wu, K. Iida, X.-Y. Lu, X. Cui, H. Jin, and J.-K. Zhu
The Arabidopsis NFYA5 Transcription Factor Is Regulated Transcriptionally and Posttranscriptionally to Promote Drought Resistance
PLANT CELL, August 1, 2008; 20(8): 2238 - 2251.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. E. Abdel-Ghany and M. Pilon
MicroRNA-mediated Systemic Down-regulation of Copper Protein Expression in Response to Low Copper Availability in Arabidopsis
J. Biol. Chem., June 6, 2008; 283(23): 15932 - 15945.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. Hudder and R. F. Novak
miRNAs: Effectors of Environmental Influences on Gene Expression and Disease
Toxicol. Sci., June 1, 2008; 103(2): 228 - 240.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
H.-H. Liu, X. Tian, Y.-J. Li, C.-A. Wu, and C.-C. Zheng
Microarray-based analysis of stress-regulated microRNAs in Arabidopsis thaliana
RNA, May 1, 2008; 14(5): 836 - 843.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
K. Vandenbroucke, S. Robbens, K. Vandepoele, D. Inze, Y. Van de Peer, and F. Van Breusegem
Hydrogen Peroxide-Induced Gene Expression across Kingdoms: A Comparative Analysis
Mol. Biol. Evol., March 1, 2008; 25(3): 507 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
C. Kutter, H. Schob, M. Stadler, F. Meins Jr., and A. Si-Ammour
MicroRNA-Mediated Regulation of Stomatal Development in Arabidopsis
PLANT CELL, August 1, 2007; 19(8): 2417 - 2429.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Yamasaki, S. E. Abdel-Ghany, C. M. Cohu, Y. Kobayashi, T. Shikanai, and M. Pilon
Regulation of Copper Homeostasis by Micro-RNA in Arabidopsis
J. Biol. Chem., June 1, 2007; 282(22): 16369 - 16378.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
R. B. Donker, J.-F. Mouillet, D.M. Nelson, and Y. Sadovsky
The expression of Argonaute2 and related microRNA biogenesis proteins in normal and hypoxic trophoblasts
Mol. Hum. Reprod., April 1, 2007; 13(4): 273 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
I. Heiber, E. Stroher, B. Raatz, I. Busse, U. Kahmann, M. W. Bevan, K.-J. Dietz, and M. Baier
The redox imbalanced Mutants of Arabidopsis Differentiate Signaling Pathways for Redox Regulation of Chloroplast Antioxidant Enzymes
Plant Physiology, April 1, 2007; 143(4): 1774 - 1788.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Ciftci-Yilmaz, M. R. Morsy, L. Song, A. Coutu, B. A. Krizek, M. W. Lewis, D. Warren, J. Cushman, E. L. Connolly, and R. Mittler
The EAR-motif of the Cys2/His2-type Zinc Finger Protein Zat7 Plays a Key Role in the Defense Response of Arabidopsis to Salinity Stress
J. Biol. Chem., March 23, 2007; 282(12): 9260 - 9268.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 2006 by the American Society of Plant Biologists