This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 19/10/2975    most recent tpc.107.052373v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Jiang, D. Articles by Amasino, R. M. Search for Related Content PubMed PubMed Citation Articles by Jiang, D. Articles by Amasino, R. M. Agricola Articles by Jiang, D. Articles by Amasino, R. M.

Arabidopsis Relatives of the Human Lysine-Specific Demethylase1 Repress the Expression of FWA and FLOWERING LOCUS C and Thus Promote the Floral Transition^[W]

^a Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore
^b Temasek Life Sciences Laboratory, Singapore 117604, Republic of Singapore
^c Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706

² Address correspondence to dbshy{at}nus.edu.sg.

The timing of the developmental transition to flowering is critical to reproductive success in plants. Here, we show that Arabidopsis thaliana homologs of human Lysine-Specific Demethylase1 (LSD1; a histone H3-Lys 4 demethylase) reduce the levels of histone H3-Lys 4 methylation in chromatin of the floral repressor FLOWERING LOCUS C (FLC) and the sporophytically silenced floral repressor FWA. Two of the homologs, LSD1-LIKE1 (LDL1) and LSD1-LIKE2 (LDL2), act in partial redundancy with FLOWERING LOCUS D (FLD; an additional homolog of LSD1) to repress FLC expression. However, LDL1 and LDL2 appear to act independently of FLD in the silencing of FWA, indicating that there is target gene specialization within this histone demethylase family. Loss of function of LDL1 and LDL2 affects DNA methylation on FWA, whereas FLC repression does not appear to involve DNA methylation; thus, members of the LDL family can participate in a range of silencing mechanisms.

This article has been cited by other articles:

				Y. He Control of the Transition to Flowering by Chromatin Modifications Mol Plant, July 1, 2009; 2(4): 554 - 564. [Abstract] [Full Text] [PDF]

				D. Jiang, X. Gu, and Y. He Establishment of the Winter-Annual Growth Habit via FRIGIDA-Mediated Histone Methylation at FLOWERING LOCUS C in Arabidopsis PLANT CELL, June 1, 2009; 21(6): 1733 - 1746. [Abstract] [Full Text] [PDF]

				A. Nottke, M. P. Colaiacovo, and Y. Shi Developmental roles of the histone lysine demethylases Development, March 15, 2009; 136(6): 879 - 889. [Abstract] [Full Text] [PDF]

				L. Niu, Y. Zhang, Y. Pei, C. Liu, and X. Cao Redundant Requirement for a Pair of PROTEIN ARGININE METHYLTRANSFERASE4 Homologs for the Proper Regulation of Arabidopsis Flowering Time Plant Physiology, September 1, 2008; 148(1): 490 - 503. [Abstract] [Full Text] [PDF]

				Compiled by, F. Tooke, T. Chiurugwi, and N. Battey Flowering Newsletter bibliography for 2007 J. Exp. Bot., July 18, 2008; (2008) ern109v1. [Full Text] [PDF]

				K. M. Veley and S. D. Michaels Functional Redundancy and New Roles for Genes of the Autonomous Floral-Promotion Pathway Plant Physiology, June 1, 2008; 147(2): 682 - 695. [Abstract] [Full Text] [PDF]

				X. Yu, L. Li, L. Li, M. Guo, J. Chory, and Y. Yin From the Cover: Modulation of brassinosteroid-regulated gene expression by jumonji domain-containing proteins ELF6 and REF6 in Arabidopsis PNAS, May 27, 2008; 105(21): 7618 - 7623. [Abstract] [Full Text] [PDF]