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MYC2 Differentially Modulates Diverse Jasmonate-Dependent Functions in Arabidopsis^[W]

^a Commonwealth Scientific and Industrial Research Organization Plant Industry, Queensland Bioscience Precinct, St. Lucia, Queensland, 4067, Australia
^b Commonwealth Scientific and Industrial Research Organization Plant Industry, Canberra, Australian Capital Territory, 2601, Australia
^c School of Plant Science, University of Tasmania, Hobart, Tasmania, 7001, Australia
^d Commonwealth Scientific and Industrial Research Organization Entomology, Long Pocket Laboratories, Indooroopilly, Queensland, 4068, Australia
^e School of Integrative Biology, University of Queensland, St. Lucia, Queensland, 4072, Australia

² Address correspondence to kemal.kazan{at}csiro.au.

The Arabidopsis thaliana basic helix-loop-helix Leu zipper transcription factor (TF) MYC2/JIN1 differentially regulates jasmonate (JA)-responsive pathogen defense (e.g., PDF1.2) and wound response (e.g., VSP) genes. In this study, genome-wide transcriptional profiling of wild type and mutant myc2/jin1 plants followed by functional analyses has revealed new roles for MYC2 in the modulation of diverse JA functions. We found that MYC2 negatively regulates Trp and Trp-derived secondary metabolism such as indole glucosinolate biosynthesis during JA signaling. Furthermore, MYC2 positively regulates JA-mediated resistance to insect pests, such as Helicoverpa armigera, and tolerance to oxidative stress, possibly via enhanced ascorbate redox cycling and flavonoid biosynthesis. Analyses of MYC2 cis binding elements and expression of MYC2-regulated genes in T-DNA insertion lines of a subset of MYC2–regulated TFs suggested that MYC2 might modulate JA responses via differential regulation of an intermediate spectrum of TFs with activating or repressing roles in JA signaling. MYC2 also negatively regulates its own expression, and this may be one of the mechanisms used in fine-tuning JA signaling. Overall, these results provide new insights into the function of MYC2 and the transcriptional coordination of the JA signaling pathway.

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