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First published online November 6, 2009; 10.1105/tpc.109.070110

The Plant Cell 21:3506-3517 (2009)
© 2009 American Society of Plant Biologists

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Novel and Expanded Roles for MAPK Signaling in Arabidopsis Stomatal Cell Fate Revealed by Cell Type–Specific Manipulations[C],[W]

Gregory R. Lamparda,1, Wolfgang Lukowitzb, Brian E. Ellisc and Dominique C. Bergmanna,2

a Department of Biology, Stanford University, Stanford, California 94305
b Department of Plant Biology, University of Georgia, Athens, Georgia 30602
c Michael Smith Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4

2 Address correspondence to dbergmann{at}stanford.edu.

Mitogen-activated protein kinase (MAPK) signaling networks regulate numerous eukaryotic biological processes. In Arabidopsis thaliana, signaling networks that contain MAPK kinases MKK4/5 and MAPKs MPK3/6 function in abiotic and biotic stress responses and regulate embryonic and stomatal development. However, how single MAPK modules direct specific output signals without cross-activating additional downstream processes is largely unknown. Studying relationships between MAPK components and downstream signaling outcomes is difficult because broad experimental manipulation of these networks is often lethal or associated with multiple phenotypes. Stomatal development in Arabidopsis follows a series of discrete, stereotyped divisions and cell state transitions. By expressing a panel of constitutively active MAPK kinase (MAPKK) variants in discrete stomatal lineage cell types, we identified a new inhibitory function of MKK4 and MKK5 in meristemoid self-renewal divisions. Furthermore, we established roles for MKK7 and MKK9 as both negative and (unexpectedly) positive regulators during the major stages of stomatal development. This has expanded the number of known MAPKKs that regulate stomatal development and allowed us to build plausible and testable subnetworks of signals. This in vivo cell type–specific assay can be adapted to study other protein families and thus may reveal insights into other complex signal transduction pathways in plants.


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Unraveling the MAPK Signaling Network in Stomatal Development
Nancy A. Eckardt
Plant Cell 2009 21: 3413. [Full Text]  



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N. A. Eckardt
Unraveling the MAPK Signaling Network in Stomatal Development
PLANT CELL, November 1, 2009; 21(11): 3413 - 3413.
[Full Text] [PDF]


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