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THE PLANT CELL, Vol 4, Issue 1 71-77, Copyright © 1992 by American Society of Plant Biologists
A Biochemical Phenotype for a Disease Resistance Gene of Maize
R. B. Meeley, G. S. Johal, S. P. Briggs and J. D. Walton
Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824-1312
In maize, major resistance to the pathogenic fungus Cochliobolus
(Helminthosporium) carbonum race 1 is determined by the dominant allele of
the nuclear locus hm. The interaction between C. carbonum race 1 and maize
is mediated by a pathogen-produced, low molecular weight compound called
HC-toxin. We recently described an enzyme from maize, called HC-toxin
reductase, that inactivates HC-toxin by pyridine nucleotide-dependent
reduction of an essential carbonyl group. We now report that this enzyme
activity is detectable only in extracts of maize that are resistant to C.
carbonum race 1 (genotype Hm/Hm or Hm/hm). In several genetic analyses, in
vitro HC-toxin reductase activity was without exception associated with
resistance to C. carbonum race 1. The results indicate that detoxification
of HC-toxin is the biochemical basis of Hm-specific resistance of maize to
infection by C. carbonum race 1.
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