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THE PLANT CELL, Vol 6, Issue 7 927-933, Copyright © 1994 by American Society of Plant Biologists
A Disease Resistance Gene in Arabidopsis with Specificity for Two Different Pathogen Avirulence Genes
S. R. Bisgrove, M. T. Simonich, N. M. Smith, A. Sattler and R. W. Innes
Department of Biology, Indiana University, Bloomington, Indiana 47405
The RPS3 and RPM1 disease resistance loci of Arabidopsis confer resistance
to Pseudomonas syringae strains that carry the avirulence genes avrB and
avrRpm1, respectively. We have previously shown that RPS3 and RPM1 are
closely linked genetically. Here, we show that RPS3 and RPM1 are in fact
the same gene. We screened a mutagenized Arabidopsis population with a P.
syringae strain carrying avrB and found 12 susceptible mutants. All 12
mutants were also susceptible to an isogenic strain carrying avrRpm1,
indicating a loss of both RPS3 and RPM1 functions. No mutants were
recovered that lost only RPS3 function. Genetic analysis of four
independent mutants revealed that the lesions were in RPS3. Thus, a single
gene in Arabidopsis confers resistance that is specific to two distinct
pathogen avirulence genes[mdash]a gene-for-genes interaction. This
observation suggests that the RPS3/RPM1 gene product can bind multiple
pathogen ligands, or alternatively, that it does not function as a
receptor.
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