Plant Cell
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (237)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chuck, G.
Right arrow Articles by Hake, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chuck, G.
Right arrow Articles by Hake, S.
Agricola
Right arrow Articles by Chuck, G.
Right arrow Articles by Hake, S.

THE PLANT CELL, Vol 8, Issue 8 1277-1289, Copyright © 1996 by American Society of Plant Biologists


RESEARCH ARTICLES

KNAT1 Induces Lobed Leaves with Ectopic Meristems When Overexpressed in Arabidopsis

G. Chuck, C. Lincoln and S. Hake
Department of Plant Biology, University of California-Berkeley, Berkeley, California 94720

Plant development depends on the activity of apical meristems, which are groups of indeterminate cells whose derivatives elaborate the organs of the mature plant. Studies of knotted1 (kn1) and related gene family members have determined potential roles for homeobox genes in the function of shoot meristems. The Arabidopsis kn1-like gene, KNAT1, is expressed in the shoot apical meristem and not in determinate organs. Here, we show that ectopic expression of KNAT1 in Arabidopsis transforms simple leaves into lobed leaves. The lobes initiate in the position of serrations yet have features of leaves, such as stipules, which form in the sinus, the region at the base of two lobes. Ectopic meristems also arise in the sinus region close to veins. Identity of the meristem, that is, vegetative or floral, depends on whether the meristem develops on a rosette or cauline leaf, respectively. Using in situ hybridization, we analyzed the expression of KNAT1 and another kn1-like homeobox gene, SHOOT MERISTEMLESS, in cauliflower mosaic virus 35S::KNAT1 transformants. KNAT1 expression is strong in vasculature, possibly explaining the proximity of the ectopic meristems to veins. After leaf cells have formed a layered meristem, SHOOT MERISTEMLESS expression begins in only a subset of these cells, demonstrating that KNAT1 is sufficient to induce meristems in the leaf. The shootlike features of the lobed leaves are consistent with the normal domain of KNAT1's expression and further suggest that kn1-related genes may have played a role in the evolution of leaf diversity.


This article has been cited by other articles:


Home page
DevelopmentHome page
M. R. Tucker, A. Hinze, E. J. Tucker, S. Takada, G. Jurgens, and T. Laux
Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo
Development, September 1, 2008; 135(17): 2839 - 2843.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
S. Depuydt, K. Dolezal, M. Van Lijsebettens, T. Moritz, M. Holsters, and D. Vereecke
Modulation of the Hormone Setting by Rhodococcus fascians Results in Ectopic KNOX Activation in Arabidopsis
Plant Physiology, March 1, 2008; 146(3): 1267 - 1281.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
G. Testone, L. Bruno, E. Condello, A. Chiappetta, A. Bruno, G. Mele, A. Tartarini, L. Spano, A. M. Innocenti, D. Mariotti, et al.
Peach [Prunus persica (L.) Batsch] KNOPE1, a class 1 KNOX orthologue to Arabidopsis BREVIPEDICELLUS/KNAT1, is misexpressed during hyperplasia of leaf curl disease
J. Exp. Bot., February 5, 2008; (2008) erm317v2.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
M. Guo, J. Thomas, G. Collins, and M. C.P. Timmermans
Direct Repression of KNOX Loci by the ASYMMETRIC LEAVES1 Complex of Arabidopsis
PLANT CELL, January 1, 2008; 20(1): 48 - 58.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
P. Soucek, P. Klima, A. Rekova, and B. Brzobohaty
Involvement of hormones and KNOXI genes in early Arabidopsis seedling development
J. Exp. Bot., October 20, 2007; (2007) erm236v1.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
N. Uchida, B. Townsley, K.-H. Chung, and N. Sinha
Regulation of SHOOT MERISTEMLESS genes via an upstream-conserved noncoding sequence coordinates leaf development
PNAS, October 2, 2007; 104(40): 15953 - 15958.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
N. Winter, G. Kollwig, S. Zhang, and F. Kragler
MPB2C, a Microtubule-Associated Protein, Regulates Non-Cell-Autonomy of the Homeodomain Protein KNOTTED1
PLANT CELL, October 1, 2007; 19(10): 3001 - 3018.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
H. M. P. Garces, C. E. M. Champagne, B. T. Townsley, S. Park, R. Malho, M. C. Pedroso, J. J. Harada, and N. R. Sinha
Evolution of asexual reproduction in leaves of the genus Kalanchoe
PNAS, September 25, 2007; 104(39): 15578 - 15583.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
R. Kumar, K. Kushalappa, D. Godt, M. S. Pidkowich, S. Pastorelli, S. R. Hepworth, and G. W. Haughn
The Arabidopsis BEL1-LIKE HOMEODOMAIN Proteins SAW1 and SAW2 Act Redundantly to Regulate KNOX Expression Spatially in Leaf Margins
PLANT CELL, September 1, 2007; 19(9): 2719 - 2735.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
H. Li, Z. He, G. Lu, S. C. Lee, J. Alonso, J. R. Ecker, and S. Luan
A WD40 Domain Cyclophilin Interacts with Histone H3 and Functions in Gene Repression and Organogenesis in Arabidopsis
PLANT CELL, August 1, 2007; 19(8): 2403 - 2416.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
H. Alonso-Cantabrana, J. J. Ripoll, I. Ochando, A. Vera, C. Ferrandiz, and A. Martinez-Laborda
Common regulatory networks in leaf and fruit patterning revealed by mutations in the Arabidopsis ASYMMETRIC LEAVES1 gene
Development, July 15, 2007; 134(14): 2663 - 2671.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
M. Dai, Y. Hu, Y. Zhao, H. Liu, and D.-X. Zhou
A WUSCHEL-LIKE HOMEOBOX Gene Represses a YABBY Gene Expression Required for Rice Leaf Development
Plant Physiology, May 1, 2007; 144(1): 380 - 390.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
V. Rossi, S. Locatelli, S. Varotto, G. Donn, R. Pirona, D. A. Henderson, H. Hartings, and M. Motto
Maize Histone Deacetylase hda101 Is Involved in Plant Development, Gene Transcription, and Sequence-Specific Modulation of Histone Modification of Genes and Repeats
PLANT CELL, April 1, 2007; 19(4): 1145 - 1162.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
T. Koyama, M. Furutani, M. Tasaka, and M. Ohme-Takagi
TCP Transcription Factors Control the Morphology of Shoot Lateral Organs via Negative Regulation of the Expression of Boundary-Specific Genes in Arabidopsis
PLANT CELL, February 1, 2007; 19(2): 473 - 484.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
A. Hay, M. Barkoulas, and M. Tsiantis
ASYMMETRIC LEAVES1 and auxin activities converge to repress BREVIPEDICELLUS expression and promote leaf development in Arabidopsis
Development, October 15, 2006; 133(20): 3955 - 3961.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
T. Sakamoto, H. Sakakibara, M. Kojima, Y. Yamamoto, H. Nagasaki, Y. Inukai, Y. Sato, and M. Matsuoka
Ectopic Expression of KNOTTED1-Like Homeobox Protein Induces Expression of Cytokinin Biosynthesis Genes in Rice
Plant Physiology, September 1, 2006; 142(1): 54 - 62.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
S. Kessler, B. Townsley, and N. Sinha
L1 Division and Differentiation Patterns Influence Shoot Apical Meristem Maintenance
Plant Physiology, August 1, 2006; 141(4): 1349 - 1362.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
I. Ochando, S. Jover-Gil, J. J. Ripoll, H. Candela, A. Vera, M. R. Ponce, A. Martinez-Laborda, and J. L. Micol
Mutations in the MicroRNA Complementarity Site of the INCURVATA4 Gene Perturb Meristem Function and Adaxialize Lateral Organs in Arabidopsis
Plant Physiology, June 1, 2006; 141(2): 607 - 619.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
Q. K.-G. Tan and V. F. Irish
The Arabidopsis Zinc Finger-Homeodomain Genes Encode Proteins with Unique Biochemical Properties That Are Coordinately Expressed during Floral Development
Plant Physiology, March 1, 2006; 140(3): 1095 - 1108.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
T. L. Phelps-Durr, J. Thomas, P. Vahab, and M. C.P. Timmermans
Maize rough sheath2 and Its Arabidopsis Orthologue ASYMMETRIC LEAVES1 Interact with HIRA, a Predicted Histone Chaperone, to Maintain knox Gene Silencing and Determinacy during Organogenesis
PLANT CELL, November 1, 2005; 17(11): 2886 - 2898.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
N. Nakayama, J. M. Arroyo, J. Simorowski, B. May, R. Martienssen, and V. F. Irish
Gene Trap Lines Define Domains of Gene Regulation in Arabidopsis Petals and Stamens
PLANT CELL, September 1, 2005; 17(9): 2486 - 2506.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
M. Norberg, M. Holmlund, and O. Nilsson
The BLADE ON PETIOLE genes act redundantly to control the growth and development of lateral organs
Development, May 1, 2005; 132(9): 2203 - 2213.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
A. D. Tattersall, L. Turner, M. R. Knox, M. J. Ambrose, T.H. N. Ellis, and J. M.I. Hofer
The Mutant crispa Reveals Multiple Roles for PHANTASTICA in Pea Compound Leaf Development
PLANT CELL, April 1, 2005; 17(4): 1046 - 1060.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
J. Harrison, M. Moller, J. Langdale, Q. Cronk, and A. Hudson
The Role of KNOX Genes in the Evolution of Morphological Novelty in Streptocarpus
PLANT CELL, February 1, 2005; 17(2): 430 - 443.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
Y. Greenboim-Wainberg, I. Maymon, R. Borochov, J. Alvarez, N. Olszewski, N. Ori, Y. Eshed, and D. Weiss
Cross Talk between Gibberellin and Cytokinin: The Arabidopsis GA Response Inhibitor SPINDLY Plays a Positive Role in Cytokinin Signaling
PLANT CELL, January 1, 2005; 17(1): 92 - 102.
[Abstract] [Full Text] [PDF]


Home page
Plant Cell PhysiolHome page
C. M. Ha, J. H. Jun, H. G. Nam, and J. C. Fletcher
BLADE-ON-PETIOLE1 Encodes a BTB/POZ Domain Protein Required for Leaf Morphogenesis in Arabidopsis thaliana
Plant Cell Physiol., October 15, 2004; 45(10): 1361 - 1370.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Bot.Home page
W. E. Friedman, R. C. Moore, and M. D. Purugganan
The evolution of plant development
Am. J. Botany, October 1, 2004; 91(10): 1726 - 1741.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
C. Champagne and N. Sinha
Compound leaves: equal to the sum of their parts?
Development, September 15, 2004; 131(18): 4401 - 4412.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
J. M. Kimbrough, R. Salinas-Mondragon, W. F. Boss, C. S. Brown, and H. W. Sederoff
The Fast and Transient Transcriptional Network of Gravity and Mechanical Stimulation in the Arabidopsis Root Apex
Plant Physiology, September 1, 2004; 136(1): 2790 - 2805.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
G. Cnops, S. Jover-Gil, J. L. Peters, P. Neyt, S. De Block, P. Robles, M. R. Ponce, T. Gerats, J. L. Micol, and M. Van Lijsebettens
The rotunda2 mutants identify a role for the LEUNIG gene in vegetative leaf morphogenesis
J. Exp. Bot., July 1, 2004; 55(402): 1529 - 1539.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
N. A. McHale and R. E. Koning
MicroRNA-Directed Cleavage of Nicotiana sylvestris PHAVOLUTA mRNA Regulates the Vascular Cambium and Structure of Apical Meristems
PLANT CELL, July 1, 2004; 16(7): 1730 - 1740.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
P. A. Stieger, A. D. Meyer, P. Kathmann, C. Frundt, I. Niederhauser, M. Barone, and C. Kuhlemeier
The orf13 T-DNA Gene of Agrobacterium rhizogenes Confers Meristematic Competence to Differentiated Cells
Plant Physiology, July 1, 2004; 135(3): 1798 - 1808.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
E. M. Engstrom, A. Izhaki, and J. L. Bowman
Promoter Bashing, microRNAs, and Knox Genes. New Insights, Regulators, and Targets-of-Regulation in the Establishment of Lateral Organ Polarity in Arabidopsis
Plant Physiology, June 1, 2004; 135(2): 685 - 694.
[Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. P. Running, M. Lavy, H. Sternberg, A. Galichet, W. Gruissem, S. Hake, N. Ori, and S. Yalovsky
Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases
PNAS, May 18, 2004; 101(20): 7815 - 7820.
[Abstract] [Full Text] [PDF]


Home page
GeneticsHome page
C. Roig, C. Pozzi, L. Santi, J. Muller, Y. Wang, M. R. Stile, L. Rossini, M. Stanca, and F. Salamini
Genetics of Barley Hooded Suppression
Genetics, May 1, 2004; 167(1): 439 - 448.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
N. A. McHale and R. E. Koning
PHANTASTICA Regulates Development of the Adaxial Mesophyll in Nicotiana Leaves
PLANT CELL, May 1, 2004; 16(5): 1251 - 1262.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
B. Chow and P. McCourt
Hormone signalling from a developmental context
J. Exp. Bot., January 2, 2004; 55(395): 247 - 251.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
F. Liu, W. Ni, M. E. Griffith, Z. Huang, C. Chang, W. Peng, H. Ma, and D. Xie
The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development
PLANT CELL, January 1, 2004; 16(1): 5 - 20.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
M. K. Deyholos, G. F. Cavaness, B. Hall, E. King, J. Punwani, J. Van Norman, and L. E. Sieburth
VARICOSE, a WD-domain protein, is required for leaf blade development
Development, December 29, 2003; 130(26): 6577 - 6588.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
J.-Y. Kim, Z. Yuan, and D. Jackson
Developmental regulation and significance of KNOX protein trafficking in Arabidopsis
Development, September 15, 2003; 130(18): 4351 - 4362.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
M. Kim, T. Pham, A. Hamidi, S. McCormick, R. K. Kuzoff, and N. Sinha
Reduced leaf complexity in tomato wiry mutants suggests a role for PHAN and KNOX genes in generating compound leaves
Development, September 15, 2003; 130(18): 4405 - 4415.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
G. Mele, N. Ori, Y. Sato, and S. Hake
The knotted1-like homeobox gene BREVIPEDICELLUS regulates cell differentiation by modulating metabolic pathways
Genes & Dev., September 1, 2003; 17(17): 2088 - 2093.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
C. W. Vroemen, A. P. Mordhorst, C. Albrecht, M. A. C. J. Kwaaitaal, and S. C. de Vries
The CUP-SHAPED COTYLEDON3 Gene Is Required for Boundary and Shoot Meristem Formation in Arabidopsis
PLANT CELL, July 1, 2003; 15(7): 1563 - 1577.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
Y. Harrar, Y. Bellec, C. Bellini, and J.-D. Faure
Hormonal Control of Cell Proliferation Requires PASTICCINO Genes
Plant Physiology, July 1, 2003; 132(3): 1217 - 1227.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
G. Theodoris, N. Inada, and M. Freeling
Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC LEAVES1 function in leaf development
PNAS, May 27, 2003; 100(11): 6837 - 6842.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
T. Greb, O. Clarenz, E. Schafer, D. Muller, R. Herrero, G. Schmitz, and K. Theres
Molecular analysis of the LATERAL SUPPRESSOR gene in Arabidopsis reveals a conserved control mechanism for axillary meristem formation
Genes & Dev., May 1, 2003; 17(9): 1175 - 1187.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
F. M. Rosin, J. K. Hart, H. T. Horner, P. J. Davies, and D. J. Hannapel
Overexpression of a Knotted-Like Homeobox Gene of Potato Alters Vegetative Development by Decreasing Gibberellin Accumulation
Plant Physiology, May 1, 2003; 132(1): 106 - 117.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
A. Hay, D. Jackson, N. Ori, and S. Hake
Analysis of the Competence to Respond to KNOTTED1 Activity in Arabidopsis Leaves Using a Steroid Induction System
Plant Physiology, April 1, 2003; 131(4): 1671 - 1680.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
M. E. Byrne, J. Simorowski, and R. A. Martienssen
ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis
Development, March 6, 2003; 129(8): 1957 - 1965.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
M. F. Tioni, D. H. Gonzalez, and R. L. Chan
Knotted1-like genes are strongly expressed in differentiated cell types in sunflower
J. Exp. Bot., February 1, 2003; 54(383): 681 - 690.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
C. M. Ha, G.-T. Kim, B. C. Kim, J. H. Jun, M. S. Soh, Y. Ueno, Y. Machida, H. Tsukaya, and H. G. Nam
The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis
Development, January 1, 2003; 130(1): 161 - 172.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. F. Martinez-Garcia, A. Virgos-Soler, and S. Prat
Control of photoperiod-regulated tuberization in potato by the Arabidopsis flowering-time gene CONSTANS
PNAS, November 12, 2002; 99(23): 15211 - 15216.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
N. Brunel, N. Leduc, P. Poupard, P. Simoneau, J.-C. Mauget, and J.-D. Viemont
KNAP2, a class I KN1-like gene is a negative marker of bud growth potential in apple trees (Malus domestica [L.] Borkh.)
J. Exp. Bot., November 1, 2002; 53(378): 2143 - 2149.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
M. K. Kumaran, J. L. Bowman, and V. Sundaresan
YABBY Polarity Genes Mediate the Repression of KNOX Homeobox Genes in Arabidopsis
PLANT CELL, November 1, 2002; 14(11): 2761 - 2770.
[Abstract] [Full Text] [PDF]


Home page
ScienceHome page
G. Bharathan, T. E. Goliber, C. Moore, S. Kessler, T. Pham, and N. R. Sinha
Homologies in Leaf Form Inferred from KNOXI Gene Expression During Development
Science, June 7, 2002; 296(5574): 1858 - 1860.
[Abstract] [Full Text] [PDF]


Home page
Plant Physiol.Home page
U. Brand, M. Grunewald, M. Hobe, and R. Simon
Regulation of CLV3 Expression by Two Homeobox Genes in Arabidopsis
Plant Physiology, June 1, 2002; 129(2): 565 - 575.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. P. Venglat, T. Dumonceaux, K. Rozwadowski, L. Parnell, V. Babic, W. Keller, R. Martienssen, G. Selvaraj, and R. Datla
The homeobox gene BREVIPEDICELLUS is a key regulator of inflorescence architecture in Arabidopsis
PNAS, March 21, 2002; (2002) 72626099.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
J. Y. Kim, Z. Yuan, M. Cilia, Z. Khalfan-Jagani, and D. Jackson
Intercellular trafficking of a KNOTTED1 green fluorescent protein fusion in the leaf and shoot meristem of Arabidopsis
PNAS, March 19, 2002; 99(6): 4103 - 4108.
[Abstract] [Full Text] [PDF]


Home page
Plant CellHome page
S. J. Douglas, G. Chuck, R. E. Dengler, L. Pelecanda, and C. D. Riggs
KNAT1 and ERECTA Regulate Inflorescence Architecture in Arabidopsis
PLANT CELL, March 1, 2002; 14(3): 547 - 558.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
J.-L. Gallois, C. Woodward, G. V. Reddy, and R. Sablowski
Combined SHOOT MERISTEMLESS and WUSCHEL trigger ectopic organogenesis in Arabidopsis
Development, January 7, 2002; 129(13): 3207 - 3217.
[Abstract] [Full Text] [PDF]