Plant Cell
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (374)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jang, J. C.
Right arrow Articles by Sheen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jang, J. C.
Right arrow Articles by Sheen, J.
Agricola
Right arrow Articles by Jang, J. C.
Right arrow Articles by Sheen, J.

THE PLANT CELL, Vol 9, Issue 1 5-19, Copyright © 1997 by American Society of Plant Biologists

RESEARCH ARTICLE

Hexokinase as a Sugar Sensor in Higher Plants

J. C. Jang, P. Leon, L. Zhou and J. Sheen
Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114

The mechanisms by which higher plants recognize and respond to sugars are largely unknown. Here, we present evidence that the first enzyme in the hexose assimilation pathway, hexokinase (HXK), acts as a sensor for plant sugar responses. Transgenic Arabidopsis plants expressing antisense hexokinase (AtHXK) genes are sugar hyposensitive, whereas plants overexpressing AtHXK are sugar hypersensitive. The transgenic plants exhibited a wide spectrum of altered sugar responses in seedling development and in gene activation and repression. Furthermore, overexpressing the yeast sugar sensor YHXK2 caused a dominant negative effect by elevating HXK catalytic activity but reducing sugar sensitivity in transgenic plants. The result suggests that HXK is a dual-function enzyme with a distinct regulatory function not interchangeable between plants and yeast.


This article has been cited by other articles:


Home page
 Plant Physiol.Home page
C. D. Mara and V. F. Irish
Two GATA Transcription Factors Are Downstream Effectors of Floral Homeotic Gene Action in Arabidopsis
Plant Physiology, June 1, 2008; 147(2): 707 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
L. Lejay, J. Wirth, M. Pervent, J. M.-F. Cross, P. Tillard, and A. Gojon
Oxidative Pentose Phosphate Pathway-Dependent Sugar Sensing as a Mechanism for Regulation of Root Ion Transporters by Photosynthesis
Plant Physiology, April 1, 2008; 146(4): 2036 - 2053.
[Abstract] [Full Text] [PDF]

Home page
 Mol PlantHome page
W.D. Teale, F.A. Ditengou, A.D. Dovzhenko, X. Li, A.M. Molendijk, B. Ruperti, I. Paponov, and K. Palme
Auxin as a Model for the Integration of Hormonal Signal Processing and Transduction
Mol Plant, March 1, 2008; 1(2): 229 - 237.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
A. J. McCormick, M. D. Cramer, and D. A. Watt
Changes in Photosynthetic Rates and Gene Expression of Leaves during a Source Sink Perturbation in Sugarcane
Ann. Bot., January 1, 2008; 101(1): 89 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
T. Aki, M. Konishi, T. Kikuchi, T. Fujimori, T. Yoneyama, and S. Yanagisawa
Distinct modulations of the hexokinase1-mediated glucose response and hexokinase1-independent processes by HYS1/CPR5 in Arabidopsis
J. Exp. Bot., September 1, 2007; 58(12): 3239 - 3248.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
Y. Yabuta, T. Mieda, M. Rapolu, A. Nakamura, T. Motoki, T. Maruta, K. Yoshimura, T. Ishikawa, and S. Shigeoka
Light regulation of ascorbate biosynthesis is dependent on the photosynthetic electron transport chain but independent of sugars in Arabidopsis
J. Exp. Bot., August 11, 2007; (2007) erm124v3.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
T. Araya, K. Noguchi, and I. Terashima
Effects of Carbohydrate Accumulation on Photosynthesis Differ between Sink and Source Leaves of Phaseolus vulgaris L.
Plant Cell Physiol., May 1, 2006; 47(5): 644 - 652.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
I. Couee, C. Sulmon, G. Gouesbet, and A. El Amrani
Involvement of soluble sugars in reactive oxygen species balance and responses to oxidative stress in plants
J. Exp. Bot., February 1, 2006; 57(3): 449 - 459.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
T. HARADA, S. SATOH, T. YOSHIOKA, and K. ISHIZAWA
Expression of Sucrose Synthase Genes Involved in Enhanced Elongation of Pondweed (Potamogeton distinctus) Turions under Anoxia
Ann. Bot., September 1, 2005; 96(4): 683 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
H. V. Davies, L. V. T. Shepherd, M. M. Burrell, F. Carrari, E. Urbanczyk-Wochniak, A. Leisse, R. D. Hancock, M. Taylor, R. Viola, H. Ross, et al.
Modulation of Fructokinase Activity of Potato (Solanum tuberosum) Results in Substantial Shifts in Tuber Metabolism
Plant Cell Physiol., July 1, 2005; 46(7): 1103 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
R. T. Teixeira, C. Knorpp, and K. Glimelius
Modified sucrose, starch, and ATP levels in two alloplasmic male-sterile lines of B. napus
J. Exp. Bot., April 1, 2005; 56(414): 1245 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
N. Avonce, B. Leyman, J. O. Mascorro-Gallardo, P. Van Dijck, J. M. Thevelein, and G. Iturriaga
The Arabidopsis Trehalose-6-P Synthase AtTPS1 Gene Is a Regulator of Glucose, Abscisic Acid, and Stress Signaling
Plant Physiology, November 1, 2004; 136(3): 3649 - 3659.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Kim, H.-i. Choi, H.-J. Ryu, J. H. Park, M. D. Kim, and S. Y. Kim
ARIA, an Arabidopsis Arm Repeat Protein Interacting with a Transcriptional Regulator of Abscisic Acid-Responsive Gene Expression, Is a Novel Abscisic Acid Signaling Component
Plant Physiology, November 1, 2004; 136(3): 3639 - 3648.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J. Price, A. Laxmi, S. K. St. Martin, and J.-C. Jang
Global Transcription Profiling Reveals Multiple Sugar Signal Transduction Mechanisms in Arabidopsis
PLANT CELL, August 1, 2004; 16(8): 2128 - 2150.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
J. C. Lloyd and O. V. Zakhleniuk
Responses of primary and secondary metabolism to sugar accumulation revealed by microarray expression analysis of the Arabidopsis mutant, pho3
J. Exp. Bot., June 1, 2004; 55(400): 1221 - 1230.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. A. Villalobos, D. Bartels, and G. Iturriaga
Stress Tolerance and Glucose Insensitive Phenotypes in Arabidopsis Overexpressing the CpMYB10 Transcription Factor Gene
Plant Physiology, May 1, 2004; 135(1): 309 - 324.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
K. Maurel, S. Sakr, F. Gerbe, A. Guilliot, M. Bonhomme, R. Rageau, and G. Petel
Sorbitol uptake is regulated by glucose through the hexokinase pathway in vegetative peach-tree buds
J. Exp. Bot., April 1, 2004; 55(398): 879 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
R. Butowt, D. Granot, and M. I. Rodriguez-Garcia
A Putative Plastidic Glucose Translocator is Expressed in Heterotrophic Tissues that do not Contain Starch, during Olive (Olea europea L.) Fruit Ripening
Plant Cell Physiol., November 15, 2003; 44(11): 1152 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
G. N. Harrington and D. R. Bush
The Bifunctional Role of Hexokinase in Metabolism and Glucose Signaling
PLANT CELL, November 1, 2003; 15(11): 2493 - 2496.
[Full Text] [PDF]

Home page
 Plant CellHome page
P. Giege, J. L. Heazlewood, U. Roessner-Tunali, A. H. Millar, A. R. Fernie, C. J. Leaver, and L. J. Sweetlove
Enzymes of Glycolysis Are Functionally Associated with the Mitochondrion in Arabidopsis Cells
PLANT CELL, September 1, 2003; 15(9): 2140 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
L. Lejay, X. Gansel, M. Cerezo, P. Tillard, C. Muller, A. Krapp, N. von Wiren, F. Daniel-Vedele, and A. Gojon
Regulation of Root Ion Transporters by Photosynthesis: Functional Importance and Relation with Hexokinase
PLANT CELL, September 1, 2003; 15(9): 2218 - 2232.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
U. Roessner-Tunali, B. Hegemann, A. Lytovchenko, F. Carrari, C. Bruedigam, D. Granot, and A. R. Fernie
Metabolic Profiling of Transgenic Tomato Plants Overexpressing Hexokinase Reveals That the Influence of Hexose Phosphorylation Diminishes during Fruit Development
Plant Physiology, September 1, 2003; 133(1): 84 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. Price, T.-C. Li, S. G. Kang, J. K. Na, and J.-C. Jang
Mechanisms of Glucose Signaling during Germination of Arabidopsis
Plant Physiology, July 1, 2003; 132(3): 1424 - 1438.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
K. E. Thum, D. E. Shasha, L. V. Lejay, and G. M. Coruzzi
Light- and Carbon-Signaling Pathways. Modeling Circuits of Interactions
Plant Physiology, June 1, 2003; 132(2): 440 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Kang and F. J. Turano
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana
PNAS, May 27, 2003; 100(11): 6872 - 6877.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. Moore, L. Zhou, F. Rolland, Q. Hall, W.-H. Cheng, Y.-X. Liu, I. Hwang, T. Jones, and J. Sheen
Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling
Science, April 11, 2003; 300(5617): 332 - 336.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
P. J. Eastmond, Y. Li, and I. A. Graham
Is trehalose-6-phosphate a regulator of sugar metabolism in plants?
J. Exp. Bot., January 3, 2003; 54(382): 533 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Bourque, R. Lemoine, A. Sequeira-Legrand, L. Fayolle, S. Delrot, and A. Pugin
The Elicitor Cryptogein Blocks Glucose Transport in Tobacco Cells
Plant Physiology, December 1, 2002; 130(4): 2177 - 2187.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
W.-H. Cheng, A. Endo, L. Zhou, J. Penney, H.-C. Chen, A. Arroyo, P. Leon, E. Nambara, T. Asami, M. Seo, et al.
A Unique Short-Chain Dehydrogenase/Reductase in Arabidopsis Glucose Signaling and Abscisic Acid Biosynthesis and Functions
PLANT CELL, November 1, 2002; 14(11): 2723 - 2743.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Gong, Z. Gong, Y. Guo, X. Chen, and J.-K. Zhu
Biochemical and Functional Characterization of PKS11, a Novel Arabidopsis Protein Kinase
J. Biol. Chem., July 26, 2002; 277(31): 28340 - 28350.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
N. V. Fedoroff
Cross-Talk in Abscisic Acid Signaling
Sci. Signal., July 9, 2002; 2002(140): re10 - re10.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
R. F. Sage
How Terrestrial Organisms Sense, Signal, and Respond to Carbon Dioxide
Integr. Comp. Biol., July 1, 2002; 42(3): 469 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Odanaka, A. B. Bennett, and Y. Kanayama
Distinct Physiological Roles of Fructokinase Isozymes Revealed by Gene-Specific Suppression of Frk1 and Frk2 Expression in Tomato
Plant Physiology, July 1, 2002; 129(3): 1119 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
C. Lu and M. J. Hills
Arabidopsis Mutants Deficient in Diacylglycerol Acyltransferase Display Increased Sensitivity to Abscisic Acid, Sugars, and Osmotic Stress during Germination and Seedling Development
Plant Physiology, July 1, 2002; 129(3): 1352 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
F. Rolland, B. Moore, and J. Sheen
Sugar Sensing and Signaling in Plants
PLANT CELL, May 1, 2002; 14(90001): S185 - 205.
[Full Text] [PDF]

Home page
 Plant Physiol.Home page
A. K. Sinha, M. G. Hofmann, U. Romer, W. Kockenberger, L. Elling, and T. Roitsch
Metabolizable and Non-Metabolizable Sugars Activate Different Signal Transduction Pathways in Tomato
Plant Physiology, April 1, 2002; 128(4): 1480 - 1489.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
J.-y. Kang, H.-i. Choi, M.-y. Im, and S. Y. Kim
Arabidopsis Basic Leucine Zipper Proteins That Mediate Stress-Responsive Abscisic Acid Signaling
PLANT CELL, February 1, 2002; 14(2): 343 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
T. Martin, O. Oswald, and I. A. Graham
Arabidopsis Seedling Growth, Storage Lipid Mobilization, and Photosynthetic Gene Expression Are Regulated by Carbon:Nitrogen Availability
Plant Physiology, February 1, 2002; 128(2): 472 - 481.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
J. Sheen
Signal Transduction in Maize and Arabidopsis Mesophyll Protoplasts
Plant Physiology, December 1, 2001; 127(4): 1466 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 Plant Cell PhysiolHome page
T. Furuichi, I. C. Mori, K. Takahashi, and S. Muto
Sugar-Induced Increase in Cytosolic Ca2+ in Arabidopsis thaliana Whole Plants
Plant Cell Physiol., October 1, 2001; 42(10): 1149 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M.-a. Ohto, K. Onai, Y. Furukawa, E. Aoki, T. Araki, and K. Nakamura
Effects of Sugar on Vegetative Development and Floral Transition in Arabidopsis
Plant Physiology, September 1, 2001; 127(1): 252 - 261.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
M. J. Paul and C. H. Foyer
Sink regulation of photosynthesis
J. Exp. Bot., July 1, 2001; 52(360): 1383 - 1400.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Bot.Home page
D. Jenkins Klus, S. Kalisz, P. S. Curtis, J. A. Teeri, and S. J. Tonsor
Family- and population-level responses to atmospheric CO2 concentration: gas exchange and the allocation of C, N, and biomass in Plantago lanceolata (Plantaginaceae)
Am. J. Botany, June 1, 2001; 88(6): 1080 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
W. S. da-Silva, G. L. Rezende, and A. Galina
Subcellular distribution and kinetic properties of cytosolic and non-cytosolic hexokinases in maize seedling roots: implications for hexose phosphorylation
J. Exp. Bot., June 1, 2001; 52(359): 1191 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
L. M. Provencher, L. Miao, N. Sinha, and W. J. Lucas
Sucrose Export Defective1 Encodes a Novel Protein Implicated in Chloroplast-to-Nucleus Signaling
PLANT CELL, May 1, 2001; 13(5): 1127 - 1141.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
R. Brouquisse, A. Evrard, D. Rolin, P. Raymond, and C. Roby
Regulation of Protein Degradation and Protease Expression by Mannose in Maize Root Tips. Pi Sequestration by Mannose May Hinder the Study of Its Signaling Properties
Plant Physiology, March 1, 2001; 125(3): 1485 - 1498.
[Abstract] [Full Text]

Home page
 DiabetesHome page
P. Ronner, C. M. Naumann, and E. Friel
Effects of Glucose and Amino Acids on Free ADP in {beta}HC9 Insulin-Secreting Cells
Diabetes, February 1, 2001; 50(2): 291 - 300.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
S.-L. Ho, Y.-C. Chao, W.-F. Tong, and S.-M. Yu
Sugar Coordinately and Differentially Regulates Growth- and Stress-Related Gene Expression via a Complex Signal Transduction Network and Multiple Control Mechanisms
Plant Physiology, February 1, 2001; 125(2): 877 - 890.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Oswald, T. Martin, P. J. Dominy, and I. A. Graham
Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression
PNAS, January 24, 2001; (2001) 21449998.
[Abstract] [Full Text]

Home page
 J Exp BotHome page
J. M. Quintero, R. Molina, J. M. Fournier, M. Benlloch, and J. Ramos
Glucose-induced activation of rubidium transport and water flux in sunflower root systems
J. Exp. Bot., January 1, 2001; 52(354): 99 - 104.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
U. Roessner, A. Luedemann, D. Brust, O. Fiehn, T. Linke, L. Willmitzer, and A. R. Fernie
Metabolic Profiling Allows Comprehensive Phenotyping of Genetically or Environmentally Modified Plant Systems
PLANT CELL, January 1, 2001; 13(1): 11 - 29.
[Abstract] [Full Text]

Home page
 GeneticsHome page
M. E. Katz, A. Masoumi, S. R. Burrows, C. G. Shirtliff, and B. F. Cheetham
The Aspergillus nidulans xprF Gene Encodes a Hexokinase-like Protein Involved in the Regulation of Extracellular Proteases
Genetics, December 1, 2000; 156(4): 1559 - 1571.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
S. I. Gibson
Plant Sugar-Response Pathways. Part of a Complex Regulatory Web
Plant Physiology, December 1, 2000; 124(4): 1532 - 1539.
[Full Text]

Home page
 Plant Physiol.Home page
Y. Fujiki, M. Ito, I. Nishida, and A. Watanabe
Multiple Signaling Pathways in Gene Expression during Sugar Starvation. Pharmacological Analysis of din Gene Expression in Suspension-Cultured Cells of Arabidopsis
Plant Physiology, November 1, 2000; 124(3): 1139 - 1148.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
J.-Y. Kim, A. Mahé, J. Brangeon, and J.-L. Prioul
A Maize Vacuolar Invertase, IVR2, Is Induced by Water Stress. Organ/Tissue Specificity and Diurnal Modulation of Expression
Plant Physiology, September 1, 2000; 124(1): 71 - 84.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
A. Wingler, T. Fritzius, A. Wiemken, T. Boller, and R. A. Aeschbacher
Trehalose Induces the ADP-Glucose Pyrophosphorylase Gene, ApL3, and Starch Synthesis in Arabidopsis
Plant Physiology, September 1, 2000; 124(1): 105 - 114.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
F. Arenas-Huertero, A. Arroyo, L. Zhou, J. Sheen, and P. León
Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar
Genes & Dev., August 15, 2000; 14(16): 2085 - 2096.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
C. Riou-Khamlichi, M. Menges, J. M. S. Healy, and J. A. H. Murray
Sugar Control of the Plant Cell Cycle: Differential Regulation of Arabidopsis D-Type Cyclin Gene Expression
Mol. Cell. Biol., July 1, 2000; 20(13): 4513 - 4521.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
E. Loreti, A. Alpi, and P. Perata
Glucose and Disaccharide-Sensing Mechanisms Modulate the Expression of alpha -amylase in Barley Embryos
Plant Physiology, July 1, 2000; 123(3): 939 - 948.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
J.-C. Jang, S. Fujioka, M. Tasaka, H. Seto, S. Takatsuto, A. Ishii, M. Aida, S. Yoshida, and J. Sheen
A critical role of sterols in embryonic patterning and meristem programming revealed by the fackel mutants of Arabidopsis thaliana
Genes & Dev., June 15, 2000; 14(12): 1485 - 1497.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Hwang, H. Sze, and J. F. Harper
A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis
PNAS, May 23, 2000; 9