Plant Cell Illumina
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (105)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, J. J.
Right arrow Articles by Sinha, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, J. J.
Right arrow Articles by Sinha, N.
Agricola
Right arrow Articles by Chen, J. J.
Right arrow Articles by Sinha, N.

THE PLANT CELL, Vol 9, Issue 8 1289-1304, Copyright © 1997 by American Society of Plant Biologists

RESEARCH ARTICLE

A Gene Fusion at a Homeobox Locus: Alterations in Leaf Shape and Implications for Morphological Evolution

J. J. Chen, B. J. Janssen, A. Williams and N. Sinha
Section of Plant Biology, University of California, Davis, California 95616

Compound leaves are seen in many angiosperm genera and are thought to be either fundamentally different from simple leaves or elaborations of simple leaves. The knotted1-like homeobox (knox) genes are known to regulate plant development. When overexpressed in homologous or heterologous species, this family of genes can cause changes in leaf morphology, including excessive leaf compounding in tomato. We describe here an instance of a spontaneously arisen fusion between a gene encoding a metabolic enzyme and a homeodomain protein. We show that the fusion results in overexpression of the homeodomain protein and a change in morphology that approximates the changes caused by overexpression of the same gene under the control of the cauliflower mosaic virus 35S promoter in transgenic plants. Exon-shuffling events can account for the modularity of proteins. If the shuffled exons are associated with altered promoters, changes in gene expression patterns can result. Our results show that gene fusions of this nature can cause changes in expression patterns that lead to altered morphology. We suggest that such phenomena may have played a role in the evolution of form.


This article has been cited by other articles:


Home page
 Plant Physiol.Home page
J. Ramirez, N. Bolduc, D. Lisch, and S. Hake
Distal Expression of knotted1 in Maize Leaves Leads to Reestablishment of Proximal/Distal Patterning and Leaf Dissection
Plant Physiology, December 1, 2009; 151(4): 1878 - 1888.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
E. Shani, Y. Burko, L. Ben-Yaakov, Y. Berger, Z. Amsellem, A. Goldshmidt, E. Sharon, and N. Ori
Stage-Specific Regulation of Solanum lycopersicum Leaf Maturation by Class 1 KNOTTED1-LIKE HOMEOBOX Proteins
PLANT CELL, October 1, 2009; 21(10): 3078 - 3092.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
R. David-Schwartz, D. Koenig, and N. R. Sinha
LYRATE Is a Key Regulator of Leaflet Initiation and Lamina Outgrowth in Tomato
PLANT CELL, October 1, 2009; 21(10): 3093 - 3104.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb ProtocHome page
S. Kimura and N. Sinha
Tomato (Solanum lycopersicum): A Model Fruit-Bearing Crop
Cold Spring Harb Protoc, November 1, 2008; 2008(12): pdb.emo105 - pdb.emo105.
[Abstract] [Full Text]

Home page
 Plant CellHome page
C. E.M. Champagne, T. E. Goliber, M. F. Wojciechowski, R. W. Mei, B. T. Townsley, K. Wang, M. M. Paz, R. Geeta, and N. R. Sinha
Compound Leaf Development and Evolution in the Legumes
PLANT CELL, November 1, 2007; 19(11): 3369 - 3378.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Uchida, B. Townsley, K.-H. Chung, and N. Sinha
Regulation of SHOOT MERISTEMLESS genes via an upstream-conserved noncoding sequence coordinates leaf development
PNAS, October 2, 2007; 104(40): 15953 - 15958.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Kessler, B. Townsley, and N. Sinha
L1 Division and Differentiation Patterns Influence Shoot Apical Meristem Maintenance
Plant Physiology, August 1, 2006; 141(4): 1349 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
N. Nakayama, J. M. Arroyo, J. Simorowski, B. May, R. Martienssen, and V. F. Irish
Gene Trap Lines Define Domains of Gene Regulation in Arabidopsis Petals and Stamens
PLANT CELL, September 1, 2005; 17(9): 2486 - 2506.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. He and H. Saedler
Heterotopic expression of MPF2 is the key to the evolution of the Chinese lantern of Physalis, a morphological novelty in Solanaceae
PNAS, April 19, 2005; 102(16): 5779 - 5784.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
A. D. Tattersall, L. Turner, M. R. Knox, M. J. Ambrose, T.H. N. Ellis, and J. M.I. Hofer
The Mutant crispa Reveals Multiple Roles for PHANTASTICA in Pea Compound Leaf Development
PLANT CELL, April 1, 2005; 17(4): 1046 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Bot.Home page
W. E. Friedman, R. C. Moore, and M. D. Purugganan
The evolution of plant development
Am. J. Botany, October 1, 2004; 91(10): 1726 - 1741.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Champagne and N. Sinha
Compound leaves: equal to the sum of their parts?
Development, September 15, 2004; 131(18): 4401 - 4412.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
P. A. Stieger, A. D. Meyer, P. Kathmann, C. Frundt, I. Niederhauser, M. Barone, and C. Kuhlemeier
The orf13 T-DNA Gene of Agrobacterium rhizogenes Confers Meristematic Competence to Differentiated Cells
Plant Physiology, July 1, 2004; 135(3): 1798 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. Roig, C. Pozzi, L. Santi, J. Muller, Y. Wang, M. R. Stile, L. Rossini, M. Stanca, and F. Salamini
Genetics of Barley Hooded Suppression
Genetics, May 1, 2004; 167(1): 439 - 448.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
H. E. E. Holtan and S. Hake
Quantitative Trait Locus Analysis of Leaf Dissection in Tomato Using Lycopersicon pennellii Segmental Introgression Lines
Genetics, November 1, 2003; 165(3): 1541 - 1550.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J.-Y. Kim, Z. Yuan, and D. Jackson
Developmental regulation and significance of KNOX protein trafficking in Arabidopsis
Development, September 15, 2003; 130(18): 4351 - 4362.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kim, T. Pham, A. Hamidi, S. McCormick, R. K. Kuzoff, and N. Sinha
Reduced leaf complexity in tomato wiry mutants suggests a role for PHAN and KNOX genes in generating compound leaves
Development, September 15, 2003; 130(18): 4405 - 4415.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Reinhardt, M. Frenz, T. Mandel, and C. Kuhlemeier
Microsurgical and laser ablation analysis of interactions between the zones and layers of the tomato shoot apical meristem
Development, September 1, 2003; 130(17): 4073 - 4083.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
F. M. Rosin, J. K. Hart, H. T. Horner, P. J. Davies, and D. J. Hannapel
Overexpression of a Knotted-Like Homeobox Gene of Potato Alters Vegetative Development by Decreasing Gibberellin Accumulation
Plant Physiology, May 1, 2003; 132(1): 106 - 117.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
M. F. Tioni, D. H. Gonzalez, and R. L. Chan
Knotted1-like genes are strongly expressed in differentiated cell types in sunflower
J. Exp. Bot., February 1, 2003; 54(383): 681 - 690.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
D. Jackson
Double Labeling of KNOTTED1 mRNA and Protein Reveals Multiple Potential Sites of Protein Trafficking in the Shoot Apex
Plant Physiology, August 1, 2002; 129(4): 1423 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
G. Bharathan, T. E. Goliber, C. Moore, S. Kessler, T. Pham, and N. R. Sinha
Homologies in Leaf Form Inferred from KNOXI Gene Expression During Development
Science, June 7, 2002; 296(5574): 1858 - 1860.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
V. Haywood, F. Kragler, and W. J. Lucas
Plasmodesmata: Pathways for Protein and Ribonucleoprotein Signaling
PLANT CELL, May 1, 2002; 14(90001): S303 - 325.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Wu, D. Weigel, and P. A. Wigge
Signaling in plants by intercellular RNA and protein movement
Genes & Dev., January 15, 2002; 16(2): 151 - 158.
[Full Text] [PDF]

Home page
 DevelopmentHome page
M. J. Scanlon, D. C. Henderson, and B. Bernstein
SEMAPHORE1 functions during the regulation of ancestrally duplicated knox genes and polar auxin transport in maize
Development, January 6, 2002; 129(11): 2663 - 2673.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
D. Jackson
The Long and the Short of It: Signaling Development through Plasmodesmata
PLANT CELL, December 1, 2001; 13(12): 2569 - 2572.
[Full Text] [PDF]

Home page
 Plant Physiol.Home page
G. Bharathan and N. R. Sinha
The Regulation of Compound Leaf Development
Plant Physiology, December 1, 2001; 127(4): 1533 - 1538.
[Full Text] [PDF]

Home page
 ScienceHome page
M. Kim, W. Canio, S. Kessler, and N. Sinha
Developmental Changes Due to Long-Distance Movement of a Homeobox Fusion Transcript in Tomato
Science, July 13, 2001; 293(5528): 287 - 289.
[Abstract] [Full Text]

Home page
 Plant CellHome page
M. Tsiantis
Control of Shoot Cell Fate: Beyond Homeoboxes
PLANT CELL, April 1, 2001; 13(4): 733 - 738.
[Full Text]

Home page
 Plant Physiol.Home page
Y. Avivi, S. Lev-Yadun, N. Morozova, L. Libs, L. Williams, J. Zhao, G. Varghese, and G. Grafi
Clausa, a Tomato Mutant with a Wide Range of Phenotypic Perturbations, Displays a Cell Type-Dependent Expression of the Homeobox Gene LeT6/TKn2
Plant Physiology, October 1, 2000; 124(2): 541 - 552.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
H. Koltai and D. M. Bird
High Throughput Cellular Localization of Specific Plant mRNAs by Liquid-Phase in Situ Reverse Transcription-Polymerase Chain Reaction of Tissue Sections
Plant Physiology, August 1, 2000; 123(4): 1203 - 1212.
[Abstract] [Full Text]

Home page
 Plant CellHome page
D. Reinhardt, T. Mandel, and C. Kuhlemeier
Auxin Regulates the Initiation and Radial Position of Plant Lateral Organs
PLANT CELL, April 1, 2000; 12(4): 507 - 518.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
N Ori, Y Eshed, G Chuck, J. Bowman, and S Hake
Mechanisms that control knox gene expression in the Arabidopsis shoot
Development, January 12, 2000; 127(24): 5523 - 5532.
[Abstract] [PDF]

Home page
 Plant CellHome page
T. Sakamoto, A. Nishimura, M. Tamaoki, M. Kuba, H. Tanaka, S. Iwahori, and M. Matsuoka
The Conserved KNOX Domain Mediates Specificity of Tobacco KNOTTED1-Type Homeodomain Proteins
PLANT CELL, August 1, 1999; 11(8): 1419 - 1432.
[Abstract] [Full Text]

Home page
 Plant Physiol.Home page
R. Zhong, J. J. Taylor, and Z.-H. Ye
Transformation of the Collateral Vascular Bundles into Amphivasal Vascular Bundles in an Arabidopsis Mutant
Plant Physiology, May 1, 1999; 120(1): 53 - 64.
[Abstract] [Full Text]

Home page
 ScienceHome page
M. C. P. Timmermans, A. Hudson, P. W. Becraft, and T. Nelson
ROUGH SHEATH2: A Myb Protein That Represses knox Homeobox Genes in Maize Lateral Organ Primordia
Science, April 2, 1999; 284(5411): 151 - 153.
[Abstract] [Full Text]

Home page
 DevelopmentHome page
T Foster, B Veit, and S Hake
Mosaic analysis of the dominant mutant, Gnarley1-R, reveals distinct lateral and transverse signaling pathways during maize leaf development
Development, January 1, 1999; 126(2): 305 - 313.
[Abstract] [PDF]

Home page
 Plant CellHome page
B. Veit
Leaf Initiation: New Developments in an Expanding Field
PLANT CELL, September 1, 1998; 10(9): 1407 - 1412.
[Full Text]

Home page
 Plant CellHome page
D. Reinhardt, F. Wittwer, T. Mandel, and C. Kuhlemeier
Localized Upregulation of a New Expansin Gene Predicts the Site of Leaf Formation in the Tomato Meristem
PLANT CELL, September 1, 1998; 10(9): 1427 - 1438.
[Abstract] [Full Text]

Home page
 Plant CellHome page
J. Doebley and L. Lukens
Transcriptional Regulators and the Evolution of Plant Form
PLANT CELL, July 1, 1998; 10(7): 1075 - 1082.
[Full Text]

Home page
 Plant Physiol.Home page
B.-J. Janssen, L. Lund, and N. Sinha
Overexpression of a Homeobox Gene, LeT6, Reveals Indeterminate Features in the Tomato Compound Leaf
Plant Physiology, July 1, 1998; 117(3): 771 - 786.
[Abstract] [Full Text]

Home page
 Genome ResHome page
T. M. Thomson, J. J. Lozano, N. Loukili, R. Carrio, F. Serras, B. Cormand, M. Valeri, V. M. Diaz, J. Abril, M. Burset, et al.
Fusion of the Human Gene for the Polyubiquitination Coeffector UEV1 with Kua, a Newly Identified Gene
Genome Res., November 1, 2000; 10(11): 1743 - 1756.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPB Publications THE PLANT CELL PLANT PHYSIOLOGY
Copyright © 1997 by the American Society of Plant Biologists