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Plant Cell Advance Online Publication
Published on January 22, 2010; 10.1105/tpc.109.072819

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Received November 15, 2009
Returned for revision December 15, 2009
Accepted December 29, 2009

Cooperation of Multiple Chromatin Modifications Can Generate Unanticipated Stability of Epigenetic States in Arabidopsis

Tuncay Baubec 1, Huy Q. Dinh 2, Ales Pecinka 1, Branislava Rakic 1, Wilfried Rozhon 1, Bonnie Wohlrab 1, Arndt von Haeseler 3, and Ortrun Mittelsten Scheid 1*

1 Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, 1030 Vienna, Austria
2 Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, 1030 Vienna, Austria; Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria
3 Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria

* To whom correspondence should be addressed. E-mail: ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at.

Epigenetic changes of gene expression can potentially be reversed by developmental programs, genetic manipulation, or pharmacological interference. However, a case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis thaliana plants, created an epiallele resistant to many mutations or inhibitor treatments that activate many other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetics and drug application provides evidence for an epigenetic double lock that is only alleviated upon the simultaneous removal of both DNA methylation and histone methylation. Therefore, the cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic states and contributes to heritable diversity of gene expression patterns.




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A Double Lock on Polyploidy-Associated Epigenetic Gene Silencing
PLANT CELL, January 1, 2010; 22(1): 3 - 3.
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