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IN BRIEF

SCARFACE GTPase Activating Protein Links Auxin Transport and Vesicle Trafficking

neckardt{at}aspb.org

The scarface (sfc) mutant exhibits fragmented cotyledon and leaf veins. Sieburth et al. (pages 1396–1411) show that SFC encodes an ADP ribosylation factor GTPase activating protein (ARF-GAP), a class with well-established roles in the regulation of vesicle trafficking. The authors characterize an allelic series of sfc mutants with distinct phenotypes and mutants in three additional genes in Arabidopsis encoding ARF-GAP domain proteins highly related to SFC, concluding that all four genes contribute to patterning of the cotyledon primary vein. Genetic analyses with known mutants in lipid-based signaling and auxin transport regulation suggested that lipid-based signaling may underlie some SFC functions and, importantly, that SFC functions in the trafficking of auxin efflux regulators. Expression of green fluorescent protein–tagged PIN-FORMED1 (PIN1) auxin transport facilitator in the sfc mutant suggested that SFC is required for normal intracellular transport of PIN1 from the plasma membrane to the endosome. The authors conclude that SFC may be a regulator of endomembrane cycling associated with PIN localization and/or with polar auxin transport.

View larger version (89K): [in this window] [in a new window]   Vein patterns in wild-type (left) and sfc1 mutant (right) cotyledons.

Related articles in Plant Cell:

SCARFACE Encodes an ARF-GAP That Is Required for Normal Auxin Efflux and Vein Patterning in Arabidopsis

Leslie E. Sieburth, Gloria K. Muday, Edward J. King, Geoff Benton, Sun Kim, Kasee E. Metcalf, Lindsay Meyers, Emylie Seamen, and Jaimie M. Van Norman
Plant Cell 2006 18: 1396-1411. [Abstract] [Full Text]  

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