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IN BRIEF

Structure–Function Analysis of Arabidopsis SNI1

neckardt{at}aspb.org

Systemic acquired resistance (SAR) is the activation of broad-spectrum resistance in plants in response to infection by an avirulent pathogen, characterized by the increased expression of numerous pathogenesis-related (PR) genes that renders the plant more resistant to secondary infection by a wide range of pathogens. Arabidopsis SNI1 is a negative regulator of SAR that is required to maintain the low basal expression of PR genes. Induction of SAR is dependent on NPR1 in Arabidopsis, and Mosher et al. (pages 1750–1765) show that many NPR1-dependent PR genes are specifically derepressed in the sni1 mutant, indicating that SNI1 functions in the NPR1 pathway. The authors provide evidence that histone modification may be involved in SNI1-mediated repression of PR genes. Based on structural similarity to Armadillo repeat proteins, the authors conclude that SNI1 may form a scaffold for interaction of transcription factors. Saturating mutagenesis of SNI1 identified regions of the protein that are required for its activity.

View larger version (31K): [in this window] [in a new window]   Modeling of SNI1 reveals an - supercoil domain that may serve as a scaffold for protein–protein interactions.

Related articles in Plant Cell:

A Comprehensive Structure–Function Analysis of Arabidopsis SNI1 Defines Essential Regions and Transcriptional Repressor Activity

Rebecca A. Mosher, Wendy E. Durrant, Dong Wang, Junqi Song, and Xinnian Dong
Plant Cell 2006 18: 1750-1765. [Abstract] [Full Text]  

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