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IN BRIEF

Arabidopsis SUPPRESSOR OF AUXIN RESISTANCE Proteins Are Nucleoporins

neckardt{at}aspb.org

The transport of macromolecules between the nucleus and cytoplasm is regulated by a large multisubunit complex called the nuclear pore complex (NPC). This complex is well characterized in animals and fungi, but there is relatively little information on the NPC in plants. Parry et al. (pages 1590–1603) show that SUPPRESSOR OF AUXIN RESISTANCE1 (SAR1) and SAR3 encode proteins with similarity to vertebrate nucleoporins, subunits of the NPC. Consistent with this function, sar1 sar3 double mutant plants and a SAR:GFP fusion protein localized to the nuclear membrane and accumulated polyadenylated RNA within the nucleus, indicating that SAR1 and SAR3 are required for mRNA export.

The study reveals a function for nucleoporin proteins in auxin signaling, helping to explain how the required signal transduction transcripts and components are transported into and out of the nucleus. Both sar1 and sar3 mutations affect localization of the transcriptional repressor AXR3/IAA17, providing an explanation for suppression of the axr1 phenotype exhibited by the sar mutants. The data further indicate that SAR1 and SAR3 are not simply redundant but interact to different degrees with other pathways. This study demonstrates the important role of the plant NPC in hormone signaling and paves the way for further analysis of the NPC in plants.

View larger version (168K): [in this window] [in a new window]   Confocal image of root tip cells shows that SAR3:GFP (green) localizes to the nuclear periphery.

Related articles in Plant Cell:

The Arabidopsis SUPPRESSOR OF AUXIN RESISTANCE Proteins Are Nucleoporins with an Important Role in Hormone Signaling and Development

Geraint Parry, Sally Ward, Alex Cernac, Sunethra Dharmasiri, and Mark Estelle
Plant Cell 2006 18: 1590-1603. [Abstract] [Full Text]  

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