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The Plant Cell 19:2703

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IN BRIEF

Shoot Meristem Development Depends on N-Myristoylation of SnRK1

Nancy A. Eckardt

News and Reviews Editor

neckardt{at}aspb.org

N-myristoylation, catalyzed by N-myristoyltransferase (NMT), is a lipid modification of the N terminus of certain proteins. N-myristoylation is known to affect the membrane binding properties of a number of proteins involved in signal transduction. Arabidopsis has two genes encoding NMTs, NMT1 and NMT2. Pierre et al. (pages 2804–2821) analyzed loss-of-function mutants of these genes and show that NMT1 is required for plant viability and has a key function in the shoot apical meristem during embryonic development, whereas NMT2 plays a role in flowering. The authors identified the heterotrimeric Ser/Thr kinase SNF1-related protein kinase SnRK1 as a potential target of NMT1 in meristems. SnRK1 previously has been found to be an important component in numerous signaling pathways fundamental to plant development, including glucose starvation, stress responses, sugar signaling, cell cycle control, and aging and has been identified as an early marker of the shoot apical meristem in Arabidopsis. Analyses of gene expression, protein activity, and subcellular localization showed that the developmental phenotype of nmt1 loss-of-function mutant plants is associated with disrupted signaling via SnRK1. Protein N-myristoylation of SnRK1 therefore appears to be critical for shoot meristem development.


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  		Knockout of NMT1 reveals a critical function of N-myristoylation in the shoot apical meristem.

 
Footnotes

www.plantcell.org/cgi/doi/10.1105/tpc.107.190910


Related articles in Plant Cell:

N-Myristoylation Regulates the SnRK1 Pathway in Arabidopsis
Michèle Pierre, José A. Traverso, Bertrand Boisson, Séverine Domenichini, David Bouchez, Carmela Giglione, and Thierry Meinnel
Plant Cell 2007 19: 2804-2821. [Abstract] [Full Text]  




This Article
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