Plant Cell Advance Online Publication
Published on February 21, 2003; 10.1105/tpc.007062
Received August 14, 2002
Accepted December 13, 2002
DRL1, a Homolog of the Yeast TOT4/KTI12 Protein, Has a Function in Meristem Activity
and Organ Growth in Plants
Hilde Nelissen 1, Jonathan H. Clarke 2, Marc De Block 3, Sabine De Block 1, Rudy Vanderhaeghen 1, Raymond E. Zielinski 4, Tristan Dyer 2, Sofie Lust 1, Dirk Inzé 1, and Mieke Van Lijsebettens 1*
1
Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology,
Ghent University, B-9000 Gent, Belgium
2
Molecular Genetics Department, John Innes Centre, Norwich NR4 7UH, United Kingdom
3 Bayer CropScience NV, B-9000 Gent, Belgium
4
Department of Plant Biology, University of Illinois, Urbana, Illinois 61801
* To whom correspondence should be addressed. E-mail: mieke.vanlijsebettens{at}gengenp.rug.ac.be.
The DEFORMED ROOTS AND LEAVES1 (DRL1) gene is single copy in the
Arabidopsis genome, and based on overall amino acid similarity and conservation of
functional domains, the DRL1 protein is homologous with yeast TOT4/KTI12. TOT4/KTI12
associates with Elongator, a multisubunit complex that binds the RNA polymerase II
transcription elongation complex. Recessive mutations at the DRL1 locus
caused defective organ formation indicative of disorganized shoot, inflorescence,
flower, and root meristems. DRL1 is a putative ATP/GTP binding protein; in addition,
calmodulin binding activity was demonstrated in vitro for the C terminus of the DRL1
protein. Phenotypic and genetic data position DRL1 relative to regulatory loci for
leaf development, in which it acts early. We identified Arabidopsis homologs for
the six Elongator components and hypothesize that DRL1 regulates transcription elongation
through a putative plant Elongator. Upregulation of the ANGUSTIFOLIA transcript
in the strong drl1-2 allele supports this model.
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