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Plant Cell Advance Online Publication
Published on February 21, 2003; 10.1105/tpc.009159

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Received November 8, 2002
Accepted December 22, 2002

NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol

Steven H. Spoel 1, Annemart Koornneef 2, Susanne M. C. Claessens 2, Jerôme P. Korzelius 2, Johan A. Van Pelt 2, Martin J. Mueller 3, Antony J. Buchala 4, Jean-Pierre Métraux 4, Rebecca Brown 5, Kemal Kazan 5, L. C. Van Loon 2, Xinnian Dong 6, and Corné M. J. Pieterse 2*

1 Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands; Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708-1000
2 Graduate School of Experimental Plant Sciences, Section of Phytopathology, Faculty of Biology, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
3 Pharmaceutical Biology, Julius-von-Sachs Institute of Biological Sciences, University of Wuerzburg, D-97082 Wuerzburg, Germany
4 Department of Biology, University of Fribourg, CH-1700 Fribourg, Switzerland
5 Cooperative Research Centre for Tropical Plant Pathology, University of Queensland, St. Lucia, Queensland 4072, Australia
6 Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708-1000

* To whom correspondence should be addressed. E-mail: c.m.j.pieterse{at}bio.uu.nl.

Plant defenses against pathogens and insects are regulated differentially by cross-communicating signal transduction pathways in which salicylic acid (SA) and jasmonic acid (JA) play key roles. In this study, we investigated the molecular mechanism of the antagonistic effect of SA on JA signaling. Arabidopsis plants unable to accumulate SA produced 25-fold higher levels of JA and showed enhanced expression of the JA-responsive genes LOX2, PDF1.2, and VSP in response to infection by Pseudomonas syringae pv tomato DC3000, indicating that in wild-type plants, pathogen-induced SA accumulation is associated with the suppression of JA signaling. Analysis of the Arabidopsis mutant npr1, which is impaired in SA signal transduction, revealed that the antagonistic effect of SA on JA signaling requires the regulatory protein NPR1. Nuclear localization of NPR1, which is essential for SA-mediated defense gene expression, is not required for the suppression of JA signaling, indicating that cross-talk between SA and JA is modulated through a novel function of NPR1 in the cytosol.




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