Plant Cell Advance Online Publication
Published on February 19, 2002; 10.1105/tpc.010373
Received August 22, 2001
Accepted October 23, 2001
Independently Regulated Neocentromere Activity of Two Classes of Tandem Repeat Arrays
Evelyn N. Hiatt 1, Edward K. Kentner 1, and R. Kelly Dawe 2*
1
Department of Genetics, University of Georgia, Athens, Georgia 30602
2
Department of Genetics, University of Georgia, Athens, Georgia 30602; Department
of Botany, University of Georgia, Athens, Georgia 30602
* To whom correspondence should be addressed. E-mail: kelly{at}dogwood.botany.uga.edu.
Tandem repeat arrays often are found in interstitial (i.e., normally gene-rich) regions
on chromosomes. In maize, genes on abnormal chromosome 10 induce the tandem repeats
that make up knobs to move poleward on the meiotic spindle. This so-called neocentromere
activity results in the preferential recovery, or meiotic drive, of the knobs in
progeny. Here we show that two classes of repeats differ in their capacity to form
neocentromeres and that their motility is controlled in trans by at least
two repeat-specific activators. Microtubule dynamics appear to contribute little
to the movement of neocentromeres (they are active in the presence of taxol), suggesting
that the mechanism of motility involves microtubule-based motors. These data suggest
that maize knob repeats and their binding proteins have coevolved to ensure their
preferential recovery in progeny. Neocentromere-mediated drive provides a plausible
mechanism for the evolution and maintenance of repeat arrays that occur in interstitial
positions.
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