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Plant Cell Advance Online Publication
Published on March 8, 2002; 10.1105/tpc.010434

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Received October 5, 2001
Accepted December 7, 2001

Cell Pattern in the Arabidopsis Root Epidermis Determined by Lateral Inhibition with Feedback

Myeong Min Lee 1 and John Schiefelbein 1*

1 Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109

* To whom correspondence should be addressed. E-mail: schiefel{at}umich.edu.

In the root epidermis of Arabidopsis, hair and nonhair cell types are specified in a distinct position-dependent pattern. Here, we show that transcriptional feedback loops between the WEREWOLF (WER), CAPRICE (CPC ), and GLABRA2 (GL2) genes help to establish this pattern. Positional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cells located in a particular position (N) and adoption of the nonhair fate. The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER, GL2, and its own gene in the alternative position (H) to induce the hair fate. These results provide a molecular genetic framework for understanding the determination of a cell-type pattern in plants.






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