Plant Cell Advance Online Publication
Published on September 5, 2003; 10.1105/tpc.013862
Received May 21, 2003
Accepted July 16, 2003
The STT3a Subunit Isoform of the Arabidopsis Oligosaccharyltransferase Controls Adaptive
Responses to Salt/Osmotic Stress
Hisashi Koiwa 1*, Fang Li 2, Michael G. McCully 2, Imelda Mendoza 3, Nozomu Koizumi 4, Yuzuki Manabe 2, Yuko Nakagawa 2, Jianhua Zhu 2, Ana Rus 2, José M. Pardo 3, Ray A. Bressan 2, and Paul M. Hasegawa 2
1
Department of Horticultural Sciences, Texas A&M University, College Station,
Texas 77843-2133
2
Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette,
Indiana 47907-2010
3
Instituto de Recursos Naturales y Agrobiologia, Consejo Superior de Investigaciones
Cientificas, Sevilla-41012, Spain
4
Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0192, Japan
* To whom correspondence should be addressed. E-mail: koiwa{at}neo.tamu.edu.
Arabidopsis stt3a-1 and stt3a-2 mutations cause NaCl/osmotic sensitivity
that is characterized by reduced cell division in the root meristem. Sequence comparison
of the STT3a gene identified a yeast ortholog, STT3, which encodes
an essential subunit of the oligosaccharyltransferase complex that is involved in
protein N-glycosylation. NaCl induces the unfolded protein response in the
endoplasmic reticulum (ER) and cell cycle arrest in root tip cells of stt3a
seedlings, as determined by expression profiling of ER stress-responsive chaperone
(BiP-GUS) and cell division (CycB1;1-GUS
) genes, respectively. Together, these results indicate that plant salt stress adaptation
involves ER stress signal regulation of cell cycle progression. Interestingly, a
mutation (stt3b-1) in another Arabidopsis STT3 isogene (STT3b)
does not cause NaCl sensitivity. However, the stt3a-1 stt3b-1 double mutation
is gametophytic lethal. Apparently, STT3a and STT3b have overlapping and essential
functions in plant growth and developmental processes, but the pivotal and specific
protein glycosylation that is a necessary for recovery from the unfolded protein
response and for cell cycle progression during salt/osmotic stress recovery is associated
uniquely with the function of the STT3a isoform.
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