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Plant Cell Advance Online Publication
Published on October 14, 2004; 10.1105/tpc.104.025072

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Received June 9, 2004
Accepted August 17, 2004

TELOMERASE ACTIVATOR1 Induces Telomerase Activity and Potentiates Responses to Auxin in Arabidopsis

Shuxin Ren 1, J. Spencer Johnston 2, Dorothy E. Shippen 3, and Thomas D. McKnight 1*

1 Department of Biology, Texas A&M University, College Station, Texas 77843-3258
2 Department of Entomology, Texas A&M University, College Station, Texas 77843-2475
3 Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128

* To whom correspondence should be addressed. E-mail: mcknight{at}bio.tamu.edu.

Telomerase activity is highly regulated, abundant in rapidly dividing cells and reproductive organs, but undetectable in most other differentiated tissues. Little is known about mechanisms that regulate telomerase. Here, we used a biochemical assay to screen activation-tagged lines of Arabidopsis thaliana for mutants that ectopically express this enzyme in their leaves. In one such mutant, a previously uncharacterized zinc-finger protein we designate TELOMERASE ACTIVATOR1 (TAC1) is overexpressed and induces telomerase in fully differentiated leaves without stimulating progression through the cell cycle. Reducing endogenous concentrations of auxin in the mutant blocks the ability of TAC1 to induce telomerase. This result, along with other phenotypes of the mutant, such as the ability of cells to grow in culture without exogenous auxin and increased sensitivity of primary root growth to exogenous auxin, indicates that TAC1 not only is part of the previously reported link between auxin and telomerase expression but also potentiates other classic responses to this phytohormone.




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