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Plant Cell Advance Online Publication
Published on July 29, 2005; 10.1105/tpc.105.033761

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Received April 27, 2005
Returned for revision June 13, 2005
Accepted June 27, 2005

The Role of the Arabidopsis E2FB Transcription Factor in Regulating Auxin-Dependent Cell Division

Zoltán Magyar 1, Lieven De Veylder 2, Ana Atanassova 2, László Bakó 3, Dirk Inzé 2, and László Bögre 4*

1 Royal Holloway University of London, School of Biological Sciences, Egham, TW20 0EX, United Kingdom; Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, B-9052 Gent, Belgium; Institute of Plant Biology, Biological Research Center, H-6701, Szeged, Hungary
2 Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, B-9052 Gent, Belgium
3 Institute of Plant Biology, Biological Research Center, H-6701, Szeged, Hungary; Department of Plant Physiology, Umeå Plant Science Center, Umeå University, S-90187 Umeå, Sweden
4 Royal Holloway University of London, School of Biological Sciences, Egham, TW20 0EX, United Kingdom

* To whom correspondence should be addressed. E-mail: l.bogre{at}rhul.ac.uk.

The molecular mechanisms by which the phytohormone auxin coordinates cell division with cell growth and differentiation are largely unknown. Here, we show that in Arabidopsis thaliana E2FB, accumulation and stability are positively regulated by auxin. Coexpression of E2FB, but not of E2FA, with its dimerization partner A, stimulated cell proliferation in the absence of auxin in tobacco (Nicotiana tabacum) Bright Yellow-2 cells. E2FB regulated the entry into both S- and M-phases, the latter corresponding to the activation of a plant-specific mitotic regulator, CDKB1;1. Increased E2FB levels led to shortened cell cycle duration, elevated cell numbers, and extremely small cell sizes. In the absence of auxin, cells elongated with concomitant increase in their ploidy level, but both were strongly inhibited by E2FB. We conclude that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.




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