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Plant Cell Advance Online Publication
Published on October 5, 2007; 10.1105/tpc.107.052373

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Received April 20, 2007
Returned for revision September 4, 2007
Accepted September 11, 2007

Arabidopsis Relatives of the Human Lysine–Specific Demethylase1 Repress the Expression of FWA and FLOWERING LOCUS C and Thus Promote the Floral Transition

Danhua Jiang 1, Wannian Yang 2, Yuehui He 2*, and Richard M. Amasino 3

1 Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore
2 Department of Biological Sciences, National University of Singapore, Singapore 117543, Republic of Singapore; Temasek Life Sciences Laboratory, Singapore 117604, Republic of Singapore
3 Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706

* To whom correspondence should be addressed. E-mail: dbshy{at}nus.edu.sg.

The timing of the developmental transition to flowering is critical to reproductive success in plants. Here, we show that Arabidopsis thaliana homologs of human Lysine-Specific Demethylase1 (LSD1; a histone H3-Lys 4 demethylase) reduce the levels of histone H3-Lys 4 methylation in chromatin of the floral repressor FLOWERING LOCUS C (FLC) and the sporophytically silenced floral repressor FWA. Two of the homologs, LSD1-LIKE1 (LDL1) and LSD1-LIKE2 (LDL2), act in partial redundancy with FLOWERING LOCUS D (FLD; an additional homolog of LSD1) to repress FLC expression. However, LDL1 and LDL2 appear to act independently of FLD in the silencing of FWA, indicating that there is target gene specialization within this histone demethylase family. Loss of function of LDL1 and LDL2 affects DNA methylation on FWA, whereas FLC repression does not appear to involve DNA methylation; thus, members of the LDL family can participate in a range of silencing mechanisms.




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