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Plant Cell Advance Online Publication
Published on August 17, 2007; 10.1105/tpc.107.053579

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Received June 11, 2007
Returned for revision July 19, 2007
Accepted July 26, 2007

A WD40 Domain Cyclophilin Interacts with Histone H3 and Functions in Gene Repression and Organogenesis in Arabidopsis

Hong Li 1, Zengyong He 1, Guihua Lu 1, Sung Chul Lee 1, Jose Alonso 2, Joseph R. Ecker 3, and Sheng Luan 1*

1 Department of Plant and Microbial Biology, University of California, Berkeley, California 94720
2 Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695
3 Plant Biology and Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037

* To whom correspondence should be addressed. E-mail: sluan{at}nature.berkeley.edu.

Chromatin-based silencing provides a crucial mechanism for the regulation of gene expression. We have identified a WD40 domain cyclophilin, CYCLOPHILIN71 (CYP71), which functions in gene repression and organogenesis in Arabidopsis thaliana. Disruption of CYP71 resulted in ectopic activation of homeotic genes that regulate meristem development. The cyp71 mutant plants displayed dramatic defects, including reduced apical meristem activity, delayed and abnormal lateral organ formation, and arrested root growth. CYP71 was associated with the chromatin of target gene loci and physically interacted with histone H3. The cyp71 mutant showed reduced methylation of H3K27 at target loci, consistent with the derepression of these genes in the mutant. As CYP71 has close homologs in eukaryotes ranging from fission yeast to human, we propose that it serves as a highly conserved histone remodeling factor involved in chromatin-based gene silencing in eukaryotic organisms.




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