Plant Cell Advance Online Publication
Published on March 28, 2008; 10.1105/tpc.108.058172
Received January 17, 2008
Returned for revision March 4, 2008
Accepted March 10, 2008
ARABIDOPSIS TRITHORAX1 Dynamically Regulates FLOWERING LOCUS C Activation via Histone 3 Lysine 4 Trimethylation
Stéphane Pien 1*, Delphine Fleury 2, Joshua S. Mylne 3, Pedro Crevillen 3, Dirk Inzé 2, Zoya Avramova 4, Caroline Dean 3, and Ueli Grossniklaus 5
1 Institute of Plant Biology, Zürich-Basel Plant Science Center, University of Zürich, Zurich CH-8008, Switzerland; Institut für Pflanzenwissenschaften, Zürich-Basel Plant Science Centre, Eidgenössische Technische Hochschule-Zentrum, Zurich CH-8092, Switzerland; Department of Plant Systems Biology, Ghent University/Vlaams Instituut voor Biotechnologie, B-9052, Belgium
2 Department of Plant Systems Biology, Ghent University/Vlaams Instituut voor Biotechnologie, B-9052, Belgium
3 Department of Cell and Development Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom
4 School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0118
5 Institute of Plant Biology, Zürich-Basel Plant Science Center, University of Zürich, Zurich CH-8008, Switzerland
* To whom correspondence should be addressed. E-mail: pien{at}botinst.uzh.ch.
Trithorax function is essential for epigenetic maintenance of gene expression in animals, but little is known about trithorax homologs in plants. ARABIDOPSIS TRITHORAX1 (ATX1) was shown to be required for the expression of homeotic genes involved in flower organogenesis. Here, we report a novel function of ATX1, namely, the epigenetic regulation of the floral repressor FLOWERING LOCUS C (FLC). Downregulation of FLC accelerates the transition from vegetative to reproductive development in Arabidopsis thaliana. In the atx1 mutant, FLC levels are reduced and the FLC chromatin is depleted of trimethylated, but not dimethylated, histone 3 lysine 4, suggesting a specific trimethylation function of ATX1. In addition, we found that ATX1 directly binds the active FLC locus before flowering and that this interaction is released upon the transition to flowering. This dynamic process stands in contrast with the stable maintenance of homeotic gene expression mediated by trithorax group proteins in animals but resembles the dynamics of plant Polycomb group function.
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