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Salicylic Acid Regulates Plasmodesmata Closure during Innate Immune Responses in Arabidopsis

Xu Wang, Ross Sager, Weier Cui, Chong Zhang, Hua Lu, Jung-Youn Lee
Xu Wang
Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711
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Ross Sager
Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711
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Weier Cui
Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711
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Chong Zhang
University of Maryland Baltimore County, Baltimore, Maryland 21250
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Hua Lu
University of Maryland Baltimore County, Baltimore, Maryland 21250
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Jung-Youn Lee
Department of Plant and Soil Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, Delaware 19711
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  • ORCID record for Jung-Youn Lee
  • For correspondence: lee@dbi.udel.edu

Published June 2013. DOI: https://doi.org/10.1105/tpc.113.110676

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  • © 2013 American Society of Plant Biologists. All rights reserved.

Abstract

In plants, mounting an effective innate immune strategy against microbial pathogens involves triggering local cell death within infected cells as well as boosting the immunity of the uninfected neighboring and systemically located cells. Although not much is known about this, it is evident that well-coordinated cell–cell signaling is critical in this process to confine infection to local tissue while allowing for the spread of systemic immune signals throughout the whole plant. In support of this notion, direct cell-to-cell communication was recently found to play a crucial role in plant defense. Here, we provide experimental evidence that salicylic acid (SA) is a critical hormonal signal that regulates cell-to-cell permeability during innate immune responses elicited by virulent bacterial infection in Arabidopsis thaliana. We show that direct exogenous application of SA or bacterial infection suppresses cell–cell coupling and that SA pathway mutants are impaired in this response. The SA- or infection-induced suppression of cell–cell coupling requires an ENHANCED DESEASE RESISTANCE1– and NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1–dependent SA pathway in conjunction with the regulator of plasmodesmal gating PLASMODESMATA-LOCATED PROTEIN5. We discuss a model wherein the SA signaling pathway and plasmodesmata-mediated cell-to-cell communication converge under an intricate regulatory loop.

  • Glossary

    SA
    salicylic acid
    PD
    plasmodesmata
    PDLP
    PD-located protein
    Pma
    P. syringae pv maculicola
    Col-0
    Columbia-0
    BTH
    benzo(1,2,3) thiadiazole-7-carbothioic acid
    Ler
    Landsberg erecta
    CFDA
    5(6)-carboxyfluorescein diacetate
    ANOVA
    analysis of variance
    • Received February 13, 2013.
    • Revised May 2, 2013.
    • Accepted May 23, 2013.
    • Published June 7, 2013.
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    Salicylic Acid Regulates Plasmodesmata Closure during Innate Immune Responses in Arabidopsis
    Xu Wang, Ross Sager, Weier Cui, Chong Zhang, Hua Lu, Jung-Youn Lee
    The Plant Cell Jun 2013, 25 (6) 2315-2329; DOI: 10.1105/tpc.113.110676

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    Salicylic Acid Regulates Plasmodesmata Closure during Innate Immune Responses in Arabidopsis
    Xu Wang, Ross Sager, Weier Cui, Chong Zhang, Hua Lu, Jung-Youn Lee
    The Plant Cell Jun 2013, 25 (6) 2315-2329; DOI: 10.1105/tpc.113.110676
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