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Interaction and Regulation Between Lipid Mediator Phosphatidic Acid and Circadian Clock Regulators

Sang-Chul Kim, Dmitri A. Nusinow, Maria L. Sorkin, Jose Pruneda-Paz, Xuemin Wang
Sang-Chul Kim
Department of Biology, University of Missouri, St. Louis, Missouri 63121Donald Danforth Plant Science Center, St. Louis, Missouri 63132
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Dmitri A. Nusinow
Donald Danforth Plant Science Center, St. Louis, Missouri 63132
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Maria L. Sorkin
Donald Danforth Plant Science Center, St. Louis, Missouri 63132Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri 63110
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Jose Pruneda-Paz
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093
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Xuemin Wang
Department of Biology, University of Missouri, St. Louis, Missouri 63121Donald Danforth Plant Science Center, St. Louis, Missouri 63132
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  • For correspondence: swang@danforthcenter.org

Published February 2019. DOI: https://doi.org/10.1105/tpc.18.00675

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  • © 2019 American Society of Plant Biologists. All rights reserved.

Abstract

Circadian clocks play important roles in regulating cellular metabolism, but the reciprocal effect that metabolism has on the clock is largely unknown in plants. Here, we show that the central glycerolipid metabolite and lipid mediator phosphatidic acid (PA) interacts with and modulates the function of the core clock regulators LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED1 (CCA1) in Arabidopsis (Arabidopsis thaliana). PA reduced the ability of LHY and CCA1 to bind the promoter of their target gene TIMING OF CAB EXPRESSION1. Increased PA accumulation and inhibition of PA-producing enzymes had opposite effects on circadian clock outputs. Diurnal change in levels of several membrane phospholipid species, including PA, observed in wild type was lost in the LHY and CCA1 double knockout mutant. Storage lipid accumulation was also affected in the clock mutants. These results indicate that the interaction of PA with the clock regulator may function as a cellular conduit to integrate the circadian clock with lipid metabolism.

  • Received September 6, 2018.
  • Revised December 7, 2018.
  • Accepted January 22, 2019.
  • Published January 23, 2019.
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Interaction and Regulation Between Lipid Mediator Phosphatidic Acid and Circadian Clock Regulators
Sang-Chul Kim, Dmitri A. Nusinow, Maria L. Sorkin, Jose Pruneda-Paz, Xuemin Wang
The Plant Cell Feb 2019, 31 (2) 399-416; DOI: 10.1105/tpc.18.00675

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Interaction and Regulation Between Lipid Mediator Phosphatidic Acid and Circadian Clock Regulators
Sang-Chul Kim, Dmitri A. Nusinow, Maria L. Sorkin, Jose Pruneda-Paz, Xuemin Wang
The Plant Cell Feb 2019, 31 (2) 399-416; DOI: 10.1105/tpc.18.00675
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The Plant Cell: 31 (2)
The Plant Cell
Vol. 31, Issue 2
Feb 2019
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