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An m6A-YTH Module Controls Developmental Timing and Morphogenesis in Arabidopsis

Laura Arribas-Hernández, Simon Bressendorff, Mathias Henning Hansen, Christian Poulsen, Susanne Erdmann, Peter Brodersen
Laura Arribas-Hernández
Department of Biology, University of Copenhagen CITY: Copenhagen N Denmark [DK]
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Simon Bressendorff
Department of Biology, University of Copenhagen CITY: Copenhagen N Denmark [DK]
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Mathias Henning Hansen
Department of Biology, University of Copenhagen CITY: Copenhagen N Denmark [DK]
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Christian Poulsen
Department of Biology, University of Copenhagen CITY: Copenhagen N Denmark [DK]
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Susanne Erdmann
University of Technology Sydney CITY: Sydney STATE: New South Wales Australia [AU]
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Peter Brodersen
University of Copenhagen CITY: Copenhagen N POSTAL_CODE: 2200 Denmark [DK]
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  • For correspondence: pbrodersen@bio.ku.dk

Published April 2018. DOI: https://doi.org/10.1105/tpc.17.00833

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  • © 2018 American Society of Plant Biologists. All rights reserved.

Abstract

Methylation of N6-adenosine (m6A) in mRNA is an important post-transcriptional gene regulatory mechanism in eukaryotes. m6A provides a binding site for effector proteins ("readers") that influence pre-mRNA splicing, mRNA degradation or translational efficiency. YT521-B homology (YTH) domain proteins are important m6A readers with established functions in animals. Plants contain more YTH domain proteins than other eukaryotes, but their biological importance remains unknown. Here, we show that the cytoplasmic Arabidopsis thaliana YTH domain proteins EVOLUTIONARILY CONSERVED C-TERMINAL REGION2/3 (ECT2/3) are required for the correct timing of leaf formation and for normal leaf morphology. These functions depend fully on intact m6A binding sites of ECT2 and ECT3, indicating that they function as m6A readers. Mutation of the close ECT2 homolog, ECT4, enhances the delayed leaf emergence and leaf morphology defects of ect2/ect3 mutants, and all three ECT proteins are expressed at leaf formation sites in the shoot apex of young seedlings and in the division zone of developing leaves. ECT2 and ECT3 are also highly expressed at early stages of trichome development and are required for trichome morphology, as previously reported for m6A itself. Overall, our study establishes the relevance of a cytoplasmic m6A-YTH regulatory module in the timing and execution of plant organogenesis.

  • Received October 26, 2017.
  • Accepted April 10, 2018.

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An m6A-YTH module functions in development
Laura Arribas-Hernández, Simon Bressendorff, Mathias Henning Hansen, Christian Poulsen, Susanne Erdmann, Peter Brodersen
The Plant Cell Apr 2018, tpc.00833.2017; DOI: 10.1105/tpc.17.00833

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An m6A-YTH module functions in development
Laura Arribas-Hernández, Simon Bressendorff, Mathias Henning Hansen, Christian Poulsen, Susanne Erdmann, Peter Brodersen
The Plant Cell Apr 2018, tpc.00833.2017; DOI: 10.1105/tpc.17.00833
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The Plant Cell: 30 (3)
The Plant Cell
Vol. 30, Issue 3
Mar 2018
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