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The complete sequence of cultivated rice (Oryza sativa) allows, among other things, analyses of patterns of transcriptional activity on a chromosomal level. Jiao et al. (pages 1641-1657) investigated the transcriptional activity of rice chromosome 4 using a tiling path microarray based on PCR-generated genomic DNA fragments. The study revealed a correlation between transcriptional activity and chromosomal organization based on cytological and molecular data. For example, euchromatic regions enriched for nonredundant gene models were more transcriptionally active in the juvenile stage, whereas heterochromatic regions enriched for transposon-related gene models were more active in the adult stage. The cover shows a collage of karyotyping of rice pachytene chromosome 4 (blue strand at bottom), the expression and density of transposonrelated gene models (top portion), and the expression and density of nonredundant gene models (lower portion) from six representative rice organ samples. Positions of the centromere (pink) and the euchromatin/ heterochromatin border (green) in the karyotyping were highlighted using fluorescence in situ hybridization.
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