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MPB2C REGULATES CELL-TO-CELL TRAFFICKING

Numerous studies on viral movement proteins and endogenous plant proteins have provided evidence for the existence of a non-cell-autonomous protein (NCAP) signaling pathway via plasmodesmata. An important class of NCAP is represented by KNOTTED1-like homedomain proteins that play key roles in meristems, such as maize KN1 and closely related Arabidopsis STM. Winter et al. (pages 3001–3018) identified the Tobacco mosaic virus movement protein binding protein MPB2C in Nicotiana and its homolog in Arabidopsis as homeodomain interacting proteins specifically recognizing STM and KN1. The authors show that MPB2C negatively regulates KN1 association to plasmodesmata and thus plays an important role in cell-to-cell trafficking of NCAPs. The cover shows a false-colored confocal image of a guard cell expressing cytosolic GFP and a microtubule-associated MPB2C-RFP fusion protein.